FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004802007> ?p ?o ?g. }

• W2004802007 endingPage "3455" @default.
• W2004802007 startingPage "3447" @default.
• W2004802007 abstract "Small molecule BH3 mimetics comprise a promising new chemotherapeutic strategy for treating relapsed or chemoresistant cancer. In this study, we investigated the cellular mechanism of action by which BM-1197, a Bcl-xL/Bcl-2 dual inhibitor, triggers apoptosis in a panel of colorectal cancer (CRC) lines. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, we determined that BM-1197 inhibited CRC cell growth in a concentration- and time-dependent manner. The 50 % inhibitory concentration (IC50) values for the most sensitive cell lines, SW620 and SW480, ranged from 0.07 to 1.10 μM in response to a 72-h treatment. In CRC cells, BM-1197 induced apoptotic death without affecting the expression of Bcl-2 family proteins. However, BM-1197 effectively triggered a conformational change in Bax, releasing Bim from Bcl-xL by disrupting the interaction between Bcl-xL and Bak/Bax. Compared with the control group, BM-1197 treatment significantly increased the fraction of SW480 cells in the sub-G1 phase, the apoptosis rate, and cellular internucleosomal DNA fragmentation. The proapoptotic activity was associated with cytochrome c release, caspase-3 activation, and PARP-1 cleavage. Collectively, BM-1197 effectively suppressed the growth of the human CRC cell line SW480 by inducing mitochondria-dependent apoptotic cell death. These data have specific implications for the in vivo analysis and clinical evaluation of BM-1197 in CRC." @default.
• W2004802007 created "2016-06-24" @default.
• W2004802007 creator A5027351488 @default.
• W2004802007 creator A5042110124 @default.
• W2004802007 creator A5043629063 @default.
• W2004802007 creator A5043966917 @default.
• W2004802007 creator A5048900400 @default.
• W2004802007 creator A5051322557 @default.
• W2004802007 creator A5061724140 @default.
• W2004802007 creator A5063235230 @default.
• W2004802007 creator A5066153198 @default.
• W2004802007 creator A5073903182 @default.
• W2004802007 date "2014-12-27" @default.
• W2004802007 modified "2023-10-12" @default.
• W2004802007 title "The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells" @default.
• W2004802007 cites W1966257707 @default.
• W2004802007 cites W2015097233 @default.
• W2004802007 cites W2017339352 @default.
• W2004802007 cites W2017951517 @default.
• W2004802007 cites W2023981717 @default.
• W2004802007 cites W2024184486 @default.
• W2004802007 cites W2027029112 @default.
• W2004802007 cites W2028083589 @default.
• W2004802007 cites W2044388181 @default.
• W2004802007 cites W2056204720 @default.
• W2004802007 cites W2056418403 @default.
• W2004802007 cites W2062132637 @default.
• W2004802007 cites W2075188262 @default.
• W2004802007 cites W2080899323 @default.
• W2004802007 cites W2087723905 @default.
• W2004802007 cites W2094052642 @default.
• W2004802007 cites W2098696935 @default.
• W2004802007 cites W2106787323 @default.
• W2004802007 cites W2112020656 @default.
• W2004802007 cites W2117692326 @default.
• W2004802007 cites W2118746891 @default.
• W2004802007 cites W2120531171 @default.
• W2004802007 cites W2124979850 @default.
• W2004802007 cites W2126709547 @default.
• W2004802007 cites W2141565020 @default.
• W2004802007 cites W2147297736 @default.
• W2004802007 cites W2150048195 @default.
• W2004802007 cites W2154438149 @default.
• W2004802007 cites W2167504781 @default.
• W2004802007 cites W2414970752 @default.
• W2004802007 cites W250475567 @default.
• W2004802007 cites W4211199921 @default.
• W2004802007 cites W80462140 @default.
• W2004802007 doi "https://doi.org/10.1007/s13277-014-2980-z" @default.
• W2004802007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25542230" @default.
• W2004802007 hasPublicationYear "2014" @default.
• W2004802007 type Work @default.
• W2004802007 sameAs 2004802007 @default.
• W2004802007 citedByCount "18" @default.
• W2004802007 countsByYear W20048020072015 @default.
• W2004802007 countsByYear W20048020072016 @default.
• W2004802007 countsByYear W20048020072017 @default.
• W2004802007 countsByYear W20048020072018 @default.
• W2004802007 countsByYear W20048020072019 @default.
• W2004802007 countsByYear W20048020072020 @default.
• W2004802007 countsByYear W20048020072021 @default.
• W2004802007 crossrefType "journal-article" @default.
• W2004802007 hasAuthorship W2004802007A5027351488 @default.
• W2004802007 hasAuthorship W2004802007A5042110124 @default.
• W2004802007 hasAuthorship W2004802007A5043629063 @default.
• W2004802007 hasAuthorship W2004802007A5043966917 @default.
• W2004802007 hasAuthorship W2004802007A5048900400 @default.
• W2004802007 hasAuthorship W2004802007A5051322557 @default.
• W2004802007 hasAuthorship W2004802007A5061724140 @default.
• W2004802007 hasAuthorship W2004802007A5063235230 @default.
• W2004802007 hasAuthorship W2004802007A5066153198 @default.
• W2004802007 hasAuthorship W2004802007A5073903182 @default.
• W2004802007 hasConcept C12519072 @default.
• W2004802007 hasConcept C149150037 @default.
• W2004802007 hasConcept C150903083 @default.
• W2004802007 hasConcept C153911025 @default.
• W2004802007 hasConcept C185592680 @default.
• W2004802007 hasConcept C190283241 @default.
• W2004802007 hasConcept C207001950 @default.
• W2004802007 hasConcept C2776789625 @default.
• W2004802007 hasConcept C2780362710 @default.
• W2004802007 hasConcept C29311851 @default.
• W2004802007 hasConcept C31573885 @default.
• W2004802007 hasConcept C43759708 @default.
• W2004802007 hasConcept C502942594 @default.
• W2004802007 hasConcept C54355233 @default.
• W2004802007 hasConcept C55493867 @default.
• W2004802007 hasConcept C62112901 @default.
• W2004802007 hasConcept C81885089 @default.
• W2004802007 hasConcept C86803240 @default.
• W2004802007 hasConcept C95444343 @default.
• W2004802007 hasConceptScore W2004802007C12519072 @default.
• W2004802007 hasConceptScore W2004802007C149150037 @default.
• W2004802007 hasConceptScore W2004802007C150903083 @default.
• W2004802007 hasConceptScore W2004802007C153911025 @default.
• W2004802007 hasConceptScore W2004802007C185592680 @default.
• W2004802007 hasConceptScore W2004802007C190283241 @default.
• W2004802007 hasConceptScore W2004802007C207001950 @default.

• next