FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004806078> ?p ?o ?g. }

• W2004806078 endingPage "698" @default.
• W2004806078 startingPage "691" @default.
• W2004806078 abstract "The pathogenesis of osteoarthritis (OA) includes cartilage degeneration, synovial inflammation, and bone changes. Slowly, the sequence and inter-relationship of these features is becoming clearer. Early models of OA suggest thinning of the subchondral plate in addition to trabecular bone changes. In the present study subchondral bone changes were studied in the canine anterior cruciate ligament transection (ACLT)-meniscectomy model. This model is characterized by intra-joint variability with respect to cartilage damage (predominantly medial) and loading (lateral unloading due to a shifted axis).In 13 Labrador dogs, OA was induced by transection of the anterior cruciate ligament and removal of the medial meniscus. Twelve weeks later, cartilage integrity was evaluated histologically using the modified Mankin score (0-11), and proteoglycan content was determined by Alcian Blue assay. Bone architecture of the tibia was quantified by micro-CT.Cartilage damage was severe in the medial compartment (Mankin score +3.5, glycosaminoglycan (GAG) content -28%) and mild in the lateral compartment (Mankin score +1.6, GAG content -15%). Thinning and porosity of the subchondral plate were only present on the medial side (-21%, +87%, respectively). Interestingly, changes in trabecular bone structure did almost not occur in the medial compartment (volume fraction -7%) but were clear in the lateral compartment (-20%).Thinning of the subchondral plate is a localized phenomenon related to cartilage degeneration while trabecular bone changes are related to mechanical (un)loading. The different mechanisms responsible for bone changes in OA should be taken in account when designing and interpreting studies interfering with bone turnover in the treatment of OA." @default.
• W2004806078 created "2016-06-24" @default.
• W2004806078 creator A5004430213 @default.
• W2004806078 creator A5017043157 @default.
• W2004806078 creator A5022871817 @default.
• W2004806078 creator A5024222644 @default.
• W2004806078 creator A5063928355 @default.
• W2004806078 creator A5068769332 @default.
• W2004806078 creator A5077676327 @default.
• W2004806078 date "2010-05-01" @default.
• W2004806078 modified "2023-10-11" @default.
• W2004806078 title "In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model" @default.
• W2004806078 cites W1564057464 @default.
• W2004806078 cites W1582640919 @default.
• W2004806078 cites W1966171234 @default.
• W2004806078 cites W1969221593 @default.
• W2004806078 cites W1973239744 @default.
• W2004806078 cites W1976595521 @default.
• W2004806078 cites W1988077877 @default.
• W2004806078 cites W1991878122 @default.
• W2004806078 cites W1992417560 @default.
• W2004806078 cites W1993573086 @default.
• W2004806078 cites W1996970202 @default.
• W2004806078 cites W1999775304 @default.
• W2004806078 cites W2000391742 @default.
• W2004806078 cites W2012643755 @default.
• W2004806078 cites W2013767402 @default.
• W2004806078 cites W2028065902 @default.
• W2004806078 cites W2033951059 @default.
• W2004806078 cites W2038975231 @default.
• W2004806078 cites W2042426452 @default.
• W2004806078 cites W2053338769 @default.
• W2004806078 cites W2053376015 @default.
• W2004806078 cites W2053538354 @default.
• W2004806078 cites W2054240665 @default.
• W2004806078 cites W2059063577 @default.
• W2004806078 cites W2063187235 @default.
• W2004806078 cites W2065056435 @default.
• W2004806078 cites W2105342812 @default.
• W2004806078 cites W2115435552 @default.
• W2004806078 cites W2124093961 @default.
• W2004806078 cites W2124263599 @default.
• W2004806078 cites W2125019670 @default.
• W2004806078 cites W2129024325 @default.
• W2004806078 cites W2143068928 @default.
• W2004806078 cites W2151739612 @default.
• W2004806078 cites W2153282190 @default.
• W2004806078 cites W2155223493 @default.
• W2004806078 cites W2156216805 @default.
• W2004806078 cites W2160178734 @default.
• W2004806078 cites W2167301035 @default.
• W2004806078 cites W2171816946 @default.
• W2004806078 cites W2256257390 @default.
• W2004806078 cites W2415449718 @default.
• W2004806078 cites W4292542165 @default.
• W2004806078 doi "https://doi.org/10.1016/j.joca.2010.01.004" @default.
• W2004806078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20175978" @default.
• W2004806078 hasPublicationYear "2010" @default.
• W2004806078 type Work @default.
• W2004806078 sameAs 2004806078 @default.
• W2004806078 citedByCount "139" @default.
• W2004806078 countsByYear W20048060782012 @default.
• W2004806078 countsByYear W20048060782013 @default.
• W2004806078 countsByYear W20048060782014 @default.
• W2004806078 countsByYear W20048060782015 @default.
• W2004806078 countsByYear W20048060782016 @default.
• W2004806078 countsByYear W20048060782017 @default.
• W2004806078 countsByYear W20048060782018 @default.
• W2004806078 countsByYear W20048060782019 @default.
• W2004806078 countsByYear W20048060782020 @default.
• W2004806078 countsByYear W20048060782021 @default.
• W2004806078 countsByYear W20048060782022 @default.
• W2004806078 countsByYear W20048060782023 @default.
• W2004806078 crossrefType "journal-article" @default.
• W2004806078 hasAuthorship W2004806078A5004430213 @default.
• W2004806078 hasAuthorship W2004806078A5017043157 @default.
• W2004806078 hasAuthorship W2004806078A5022871817 @default.
• W2004806078 hasAuthorship W2004806078A5024222644 @default.
• W2004806078 hasAuthorship W2004806078A5063928355 @default.
• W2004806078 hasAuthorship W2004806078A5068769332 @default.
• W2004806078 hasAuthorship W2004806078A5077676327 @default.
• W2004806078 hasBestOaLocation W20048060781 @default.
• W2004806078 hasConcept C105702510 @default.
• W2004806078 hasConcept C111368507 @default.
• W2004806078 hasConcept C120665830 @default.
• W2004806078 hasConcept C121332964 @default.
• W2004806078 hasConcept C127313418 @default.
• W2004806078 hasConcept C142724271 @default.
• W2004806078 hasConcept C185592680 @default.
• W2004806078 hasConcept C189178095 @default.
• W2004806078 hasConcept C203635412 @default.
• W2004806078 hasConcept C204787440 @default.
• W2004806078 hasConcept C2776164576 @default.
• W2004806078 hasConcept C2777236700 @default.
• W2004806078 hasConcept C2778434673 @default.
• W2004806078 hasConcept C2779335624 @default.
• W2004806078 hasConcept C2780423099 @default.
• W2004806078 hasConcept C2780550940 @default.

• next