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- W2004809018 abstract "Considerations in the choice of secondary clinical outcomes in clinical trials are briefly discussed, as is the role that such outcomes may play in monitoring for early trial stoppage. Biases that may arise in the testing and estimation of treatment effects on secondary outcomes are noted, including those related to multiplicity of outcomes and to sequential aspects of trial monitoring. Methodologic research needs are outlined both in circumstances in which monitoring is based on the designated primary outcome, and under more complex monitoring procedures involving primary and secondary outcomes. The Women's Health Initiative Clinical Trial is used for illustration." @default.
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- W2004809018 date "1997-12-01" @default.
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- W2004809018 title "Discussion: On the role and analysis of secondary outcomes in clinical trials" @default.
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- W2004809018 doi "https://doi.org/10.1016/s0197-2456(96)00105-5" @default.
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