FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004809077> ?p ?o ?g. }

• W2004809077 endingPage "98" @default.
• W2004809077 startingPage "91" @default.
• W2004809077 abstract "Single-nucleotide polymorphisms (SNP) in the interleukin 28B (IL-28B) gene region are strongly predictive of the response of infected patients to antiviral therapy for hepatitis C virus (HCV). We sought to determine the prevalence of SNP IL-28B rs12979860 C/C and non-C/C (C/T plus T/T) genotypes in HCV-related cryoglobulinemic vasculitis (CV), as compared with HCV-positive patients without CV. We also searched for their association with peculiar clinical manifestations of CV and potential influence on the complete response (virological, molecular, and immunological) to the therapy.The study cohort comprised 159 and 172 HCV-infected patients with and without CV, respectively, prospectively followed starting from 1990. SNP rs12979860 genotyping was performed by Taq-Man allelic discrimination. In 106 patients (66.6%) with CV, the profile of circulating B cell clonalities was determined as well. All patients with CV were treated with pegylated interferon-α/ribavirin-based antiviral therapy.The T/T IL-28B genotype was more common in patients with CV than in those without (17% vs 8.1%, p = 0.02). In patients with CV, compared with non-C/C variants, the IL-28B C/C genotype was associated with a higher rate of complete response (52.6% vs 39.2%, p = 0.13), whereas a treatment response of 61.4% was demonstrated when solely virological response was considered (p = 0.008). A higher frequency of expanded B cell clonalities in the circulation (84.2% vs 55.9%; p = 0.005), kidney involvement (21% vs 2.9%; p = 0.003), and B cell non-Hodgkin lymphoma (17.5% vs 6.8%; p = 0.048), were also observed.In HCV-positive patients with CV, the IL-28B C/C genotype is distinguished biologically by a higher frequency of restriction of B cell response and clinically by a higher risk of cryoglobulinemic nephropathy and B cell malignancies, while acting as an independent predictor of a sustained virological response to antiviral therapy. In addition, we found that IL-28B T/T variant was more prevalent in patients with CV than in those without." @default.
• W2004809077 created "2016-06-24" @default.
• W2004809077 creator A5011114134 @default.
• W2004809077 creator A5022557606 @default.
• W2004809077 creator A5024383912 @default.
• W2004809077 creator A5026038725 @default.
• W2004809077 creator A5034237132 @default.
• W2004809077 creator A5042277842 @default.
• W2004809077 creator A5055283017 @default.
• W2004809077 creator A5055332109 @default.
• W2004809077 creator A5063922011 @default.
• W2004809077 creator A5066185290 @default.
• W2004809077 date "2013-12-01" @default.
• W2004809077 modified "2023-10-16" @default.
• W2004809077 title "Interleukin 28B Gene Polymorphisms in Hepatitis C Virus-related Cryoglobulinemic Vasculitis" @default.
• W2004809077 cites W1927008944 @default.
• W2004809077 cites W1980580135 @default.
• W2004809077 cites W1984486655 @default.
• W2004809077 cites W1986293653 @default.
• W2004809077 cites W1992004393 @default.
• W2004809077 cites W1995901131 @default.
• W2004809077 cites W2009064936 @default.
• W2004809077 cites W2017013905 @default.
• W2004809077 cites W2017046893 @default.
• W2004809077 cites W2017465968 @default.
• W2004809077 cites W2018446644 @default.
• W2004809077 cites W2019985783 @default.
• W2004809077 cites W2026614040 @default.
• W2004809077 cites W2039217616 @default.
• W2004809077 cites W2042707268 @default.
• W2004809077 cites W2051131317 @default.
• W2004809077 cites W2063285149 @default.
• W2004809077 cites W2063760041 @default.
• W2004809077 cites W2075310026 @default.
• W2004809077 cites W2077477264 @default.
• W2004809077 cites W2077515082 @default.
• W2004809077 cites W2078318266 @default.
• W2004809077 cites W2086414517 @default.
• W2004809077 cites W2087976968 @default.
• W2004809077 cites W2090978265 @default.
• W2004809077 cites W2108035402 @default.
• W2004809077 cites W2108302171 @default.
• W2004809077 cites W2111559593 @default.
• W2004809077 cites W2125963799 @default.
• W2004809077 cites W2138113954 @default.
• W2004809077 cites W2143559032 @default.
• W2004809077 cites W2156236127 @default.
• W2004809077 cites W2164098454 @default.
• W2004809077 cites W2331269392 @default.
• W2004809077 cites W2426740610 @default.
• W2004809077 doi "https://doi.org/10.3899/jrheum.130527" @default.
• W2004809077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24293567" @default.
• W2004809077 hasPublicationYear "2013" @default.
• W2004809077 type Work @default.
• W2004809077 sameAs 2004809077 @default.
• W2004809077 citedByCount "11" @default.
• W2004809077 countsByYear W20048090772014 @default.
• W2004809077 countsByYear W20048090772015 @default.
• W2004809077 countsByYear W20048090772016 @default.
• W2004809077 countsByYear W20048090772017 @default.
• W2004809077 countsByYear W20048090772018 @default.
• W2004809077 countsByYear W20048090772020 @default.
• W2004809077 countsByYear W20048090772022 @default.
• W2004809077 crossrefType "journal-article" @default.
• W2004809077 hasAuthorship W2004809077A5011114134 @default.
• W2004809077 hasAuthorship W2004809077A5022557606 @default.
• W2004809077 hasAuthorship W2004809077A5024383912 @default.
• W2004809077 hasAuthorship W2004809077A5026038725 @default.
• W2004809077 hasAuthorship W2004809077A5034237132 @default.
• W2004809077 hasAuthorship W2004809077A5042277842 @default.
• W2004809077 hasAuthorship W2004809077A5055283017 @default.
• W2004809077 hasAuthorship W2004809077A5055332109 @default.
• W2004809077 hasAuthorship W2004809077A5063922011 @default.
• W2004809077 hasAuthorship W2004809077A5066185290 @default.
• W2004809077 hasConcept C104317684 @default.
• W2004809077 hasConcept C126322002 @default.
• W2004809077 hasConcept C135763542 @default.
• W2004809077 hasConcept C139275648 @default.
• W2004809077 hasConcept C153209595 @default.
• W2004809077 hasConcept C203014093 @default.
• W2004809077 hasConcept C2522874641 @default.
• W2004809077 hasConcept C2776015282 @default.
• W2004809077 hasConcept C2776408679 @default.
• W2004809077 hasConcept C2776455275 @default.
• W2004809077 hasConcept C2776461080 @default.
• W2004809077 hasConcept C2779134260 @default.
• W2004809077 hasConcept C2780040827 @default.
• W2004809077 hasConcept C55493867 @default.
• W2004809077 hasConcept C71924100 @default.
• W2004809077 hasConcept C86803240 @default.
• W2004809077 hasConcept C90924648 @default.
• W2004809077 hasConceptScore W2004809077C104317684 @default.
• W2004809077 hasConceptScore W2004809077C126322002 @default.
• W2004809077 hasConceptScore W2004809077C135763542 @default.
• W2004809077 hasConceptScore W2004809077C139275648 @default.
• W2004809077 hasConceptScore W2004809077C153209595 @default.
• W2004809077 hasConceptScore W2004809077C203014093 @default.
• W2004809077 hasConceptScore W2004809077C2522874641 @default.

• next