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- W2004809968 abstract "Increased levels of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), is an independent risk factor of various diseases. Clinical studies report that people born with severe HHcy develop skeletal malformations with weaker bone. Studies also report that altered mitochondrial dynamics and altered epigenetics contribute to weaker bones and bone diseases. Although Hcy-induced mitochondrial dysfunction has been shown to affect bone metabolism, the role of mitochondrial epigenetics (mito-epigenetics) has not been studied in bones. The epigenetics in mitochondria is interesting as the mitochondrial genome size is small (16 kb) with fewer CpG, and without histones and introns. Recently, fascinating works on epigenetics along with the discovery of histone-like proteins in mitochondria are giving exciting areas for novel studies on mitochondria epigenetics. There are mutual cause and effect relationships between bone, mitochondria, Hcy, and epigenetics, but unfortunately, studies are lacking that describe the involvement of all these together in bone disease progression. This review describes the reciprocal relationships and mechanisms of Hcy-bone-mitochondria-epigenetics along with a short discussion of techniques which could be employed to assess Hcy-induced anomaly in bone, mediated through alterations in mito-epigenetics." @default.
- W2004809968 created "2016-06-24" @default.
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- W2004809968 date "2014-06-18" @default.
- W2004809968 modified "2023-09-24" @default.
- W2004809968 title "Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia" @default.
- W2004809968 cites W1519160353 @default.
- W2004809968 cites W178655038 @default.
- W2004809968 cites W1964129973 @default.
- W2004809968 cites W1974213596 @default.
- W2004809968 cites W1978260154 @default.
- W2004809968 cites W1983135596 @default.
- W2004809968 cites W1990153575 @default.
- W2004809968 cites W1990851733 @default.
- W2004809968 cites W1992534583 @default.
- W2004809968 cites W1996922800 @default.
- W2004809968 cites W1997446136 @default.
- W2004809968 cites W2002198698 @default.
- W2004809968 cites W2002738885 @default.
- W2004809968 cites W2005927891 @default.
- W2004809968 cites W2006630981 @default.
- W2004809968 cites W2010693203 @default.
- W2004809968 cites W2013810617 @default.
- W2004809968 cites W2015536893 @default.
- W2004809968 cites W2016194227 @default.
- W2004809968 cites W2017293256 @default.
- W2004809968 cites W2017622472 @default.
- W2004809968 cites W2019161673 @default.
- W2004809968 cites W2020102443 @default.
- W2004809968 cites W2020231266 @default.
- W2004809968 cites W2027217648 @default.
- W2004809968 cites W2027592271 @default.
- W2004809968 cites W2027619236 @default.
- W2004809968 cites W2027845077 @default.
- W2004809968 cites W2028928108 @default.
- W2004809968 cites W2029916187 @default.
- W2004809968 cites W2030569291 @default.
- W2004809968 cites W2030648432 @default.
- W2004809968 cites W2030750205 @default.
- W2004809968 cites W2033235523 @default.
- W2004809968 cites W2036902714 @default.
- W2004809968 cites W2039191702 @default.
- W2004809968 cites W2041082788 @default.
- W2004809968 cites W2041281768 @default.
- W2004809968 cites W2042577535 @default.
- W2004809968 cites W2044256528 @default.
- W2004809968 cites W2045969674 @default.
- W2004809968 cites W2050931169 @default.
- W2004809968 cites W2052151860 @default.
- W2004809968 cites W2054166336 @default.
- W2004809968 cites W2055315206 @default.
- W2004809968 cites W2057294869 @default.
- W2004809968 cites W2057390421 @default.
- W2004809968 cites W2057501022 @default.
- W2004809968 cites W2061460256 @default.
- W2004809968 cites W2065001720 @default.
- W2004809968 cites W2065534396 @default.
- W2004809968 cites W2068015531 @default.
- W2004809968 cites W2069885842 @default.
- W2004809968 cites W2070806957 @default.
- W2004809968 cites W2072942782 @default.
- W2004809968 cites W2076887674 @default.
- W2004809968 cites W2077958519 @default.
- W2004809968 cites W2078460274 @default.
- W2004809968 cites W2085610285 @default.
- W2004809968 cites W2090789857 @default.
- W2004809968 cites W2092754338 @default.
- W2004809968 cites W2093726653 @default.
- W2004809968 cites W2095495271 @default.
- W2004809968 cites W2095602231 @default.
- W2004809968 cites W2095939030 @default.
- W2004809968 cites W2119443108 @default.
- W2004809968 cites W2125352278 @default.
- W2004809968 cites W2138736783 @default.
- W2004809968 cites W2138821459 @default.
- W2004809968 cites W2139718273 @default.
- W2004809968 cites W2141220293 @default.
- W2004809968 cites W2145582821 @default.
- W2004809968 cites W2151087545 @default.
- W2004809968 cites W2160296469 @default.
- W2004809968 cites W2161919260 @default.
- W2004809968 cites W2201094204 @default.
- W2004809968 cites W4302854635 @default.
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- W2004809968 doi "https://doi.org/10.1007/s11010-014-2114-3" @default.
- W2004809968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4134425" @default.
- W2004809968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24939359" @default.
- W2004809968 hasPublicationYear "2014" @default.
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