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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004843136> ?p ?o ?g. }

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• W2004843136 abstract "The discovery and optimization of a novel class of carbon-linked dihydropyrones as allosteric HCV NS5B polymerase inhibitors are presented. Replacement of the sulfur linker atom with carbon reduced compound acidity and greatly increased cell permeation. Further structure−activity relationship (SAR) studies led to the identification of compounds, exemplified by 23 and 24, with significantly improved antiviral activities in the cell-based replicon assay and favorable pharmacokinetic profiles." @default.
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• W2004843136 date "2007-07-21" @default.
• W2004843136 modified "2023-09-24" @default.
• W2004843136 title "Allosteric Inhibitors of Hepatitis C Polymerase: Discovery of Potent and Orally Bioavailable Carbon-Linked Dihydropyrones" @default.
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• W2004843136 doi "https://doi.org/10.1021/jm0704447" @default.
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