Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004849377> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2004849377 abstract "Abstract Cellular and nuclear uptake of tri-iodothyronine (T 3 ) and thyroxine (T 4 ) was examined using the cultured cell line derived from rat liver, clone 9, and rat hepatoma, dRLH-84. The saturable cellular uptake of T 3 and T 4 was demonstrated in these cells. First we examined the cell cycle-dependent alteration of thyroid hormone uptake. Cellular T 3 uptake was minimal in the early G1 phase and increased in the late G1 phase, reaching a maximal level in the S phase. Alterations in nuclear T 3 uptake were in accordance with the changes in cellular T 3 uptake. On the other hand, cellular and nuclear T 4 uptake was unchanged throughout the cell cycle, suggesting the T 3 specificity of the cell cycle-dependent alteration of cellular hormone transport. Next we examined the effect of sodium butyrate on the cellular transport of thyroid hormones. After treatment with 5 mm sodium butyrate, cellular and nuclear uptake of T 3 was increased, reaching a maximal level (four- to sevenfold increase) after 48 h. When cells were incubated for 48 h with various concentrations of sodium butyrate, T 3 uptake was enhanced by 1 mm sodium butyrate, reaching a maximal level with 5 mm. Although cellular T 4 uptake was also increased after treatment with sodium butyrate, the degree and time-course of the increase were different from those of T 3 . The maximal increase in cellular T 4 uptake (two- to threefold increase) was attained 20 h after treatment. Despite the increase in cellular T 4 uptake, nuclear T 4 uptake was decreased after treatment with sodium butyrate. For both T 3 and T 4 , the enhanced cellular uptake was due to the increased V max without changes in the Michaelis–Menten constant. These data indicate that cellular transport of T 4 is different from that of T 3 in rat hepatic cells. Journal of Endocrinology (1995) 147, 479–485" @default.
- W2004849377 created "2016-06-24" @default.
- W2004849377 creator A5001232482 @default.
- W2004849377 creator A5014432911 @default.
- W2004849377 creator A5030293302 @default.
- W2004849377 creator A5038584582 @default.
- W2004849377 creator A5040331850 @default.
- W2004849377 creator A5062001134 @default.
- W2004849377 creator A5063714633 @default.
- W2004849377 creator A5074623366 @default.
- W2004849377 creator A5078911833 @default.
- W2004849377 creator A5086272368 @default.
- W2004849377 date "1995-12-01" @default.
- W2004849377 modified "2023-09-26" @default.
- W2004849377 title "Differences in cellular transport of tri-iodothyronine and thyroxine: cell cycle-dependent alteration of tri-iodothyronine uptake" @default.
- W2004849377 doi "https://doi.org/10.1677/joe.0.1470479" @default.
- W2004849377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8543918" @default.
- W2004849377 hasPublicationYear "1995" @default.
- W2004849377 type Work @default.
- W2004849377 sameAs 2004849377 @default.
- W2004849377 citedByCount "2" @default.
- W2004849377 crossrefType "journal-article" @default.
- W2004849377 hasAuthorship W2004849377A5001232482 @default.
- W2004849377 hasAuthorship W2004849377A5014432911 @default.
- W2004849377 hasAuthorship W2004849377A5030293302 @default.
- W2004849377 hasAuthorship W2004849377A5038584582 @default.
- W2004849377 hasAuthorship W2004849377A5040331850 @default.
- W2004849377 hasAuthorship W2004849377A5062001134 @default.
- W2004849377 hasAuthorship W2004849377A5063714633 @default.
- W2004849377 hasAuthorship W2004849377A5074623366 @default.
- W2004849377 hasAuthorship W2004849377A5078911833 @default.
- W2004849377 hasAuthorship W2004849377A5086272368 @default.
- W2004849377 hasConcept C100544194 @default.
- W2004849377 hasConcept C126322002 @default.
- W2004849377 hasConcept C134018914 @default.
- W2004849377 hasConcept C1491633281 @default.
- W2004849377 hasConcept C178790620 @default.
- W2004849377 hasConcept C185592680 @default.
- W2004849377 hasConcept C2776979534 @default.
- W2004849377 hasConcept C2778942008 @default.
- W2004849377 hasConcept C29537977 @default.
- W2004849377 hasConcept C537181965 @default.
- W2004849377 hasConcept C54355233 @default.
- W2004849377 hasConcept C55493867 @default.
- W2004849377 hasConcept C62231903 @default.
- W2004849377 hasConcept C71315377 @default.
- W2004849377 hasConcept C71924100 @default.
- W2004849377 hasConcept C81885089 @default.
- W2004849377 hasConcept C86803240 @default.
- W2004849377 hasConceptScore W2004849377C100544194 @default.
- W2004849377 hasConceptScore W2004849377C126322002 @default.
- W2004849377 hasConceptScore W2004849377C134018914 @default.
- W2004849377 hasConceptScore W2004849377C1491633281 @default.
- W2004849377 hasConceptScore W2004849377C178790620 @default.
- W2004849377 hasConceptScore W2004849377C185592680 @default.
- W2004849377 hasConceptScore W2004849377C2776979534 @default.
- W2004849377 hasConceptScore W2004849377C2778942008 @default.
- W2004849377 hasConceptScore W2004849377C29537977 @default.
- W2004849377 hasConceptScore W2004849377C537181965 @default.
- W2004849377 hasConceptScore W2004849377C54355233 @default.
- W2004849377 hasConceptScore W2004849377C55493867 @default.
- W2004849377 hasConceptScore W2004849377C62231903 @default.
- W2004849377 hasConceptScore W2004849377C71315377 @default.
- W2004849377 hasConceptScore W2004849377C71924100 @default.
- W2004849377 hasConceptScore W2004849377C81885089 @default.
- W2004849377 hasConceptScore W2004849377C86803240 @default.
- W2004849377 hasLocation W20048493771 @default.
- W2004849377 hasLocation W20048493772 @default.
- W2004849377 hasOpenAccess W2004849377 @default.
- W2004849377 hasPrimaryLocation W20048493771 @default.
- W2004849377 hasRelatedWork W1970185645 @default.
- W2004849377 hasRelatedWork W1970877815 @default.
- W2004849377 hasRelatedWork W1990311301 @default.
- W2004849377 hasRelatedWork W2001322538 @default.
- W2004849377 hasRelatedWork W2027210979 @default.
- W2004849377 hasRelatedWork W2032209516 @default.
- W2004849377 hasRelatedWork W2060981066 @default.
- W2004849377 hasRelatedWork W2356448472 @default.
- W2004849377 hasRelatedWork W2364271926 @default.
- W2004849377 hasRelatedWork W3031410976 @default.
- W2004849377 isParatext "false" @default.
- W2004849377 isRetracted "false" @default.
- W2004849377 magId "2004849377" @default.
- W2004849377 workType "article" @default.