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- W2004861522 abstract "c-Abl tyrosine kinase, which is ubiquitously expressed, has three nuclear localization signals and one nuclear export signal and can shuttle between the nucleus and the cytoplasm. c-Abl plays important roles in cell proliferation, adhesion, migration, and apoptosis. Recently, we developed a pixel imaging method for quantitating the level of chromatin structural changes and showed that nuclear Src-family tyrosine kinases are involved in chromatin structural changes upon growth factor stimulation. Using this method, we show here that nuclear c-Abl induces chromatin structural changes in a manner dependent on the tyrosine kinase activity. Expression of nuclear-targeted c-Abl drastically increases the levels of chromatin structural changes, compared with that of c-Abl. Intriguingly, nuclear-targeted c-Abl induces heterochromatic profiles of histone methylation and acetylation, including hypoacetylation of histone H4 acetylated on lysine 16 (H4K16Ac). The level of heterochromatic histone modifications correlates with that of chromatin structural changes. Adriamycin-induced DNA damage stimulates translocation of c-Abl into the nucleus and induces chromatin structural changes together with H4K16 hypoacetylation. Treatment with trichostatin A, a histone deacetylase inhibitor, blocks chromatin structural changes but not nuclear tyrosine phosphorylation by c-Abl. These results suggest that nuclear c-Abl plays an important role in chromatin dynamics through nuclear tyrosine phosphorylation-induced heterochromatic histone modifications." @default.
- W2004861522 created "2016-06-24" @default.
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- W2004861522 date "2011-12-01" @default.
- W2004861522 modified "2023-09-27" @default.
- W2004861522 title "Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation" @default.
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- W2004861522 cites W1591022300 @default.
- W2004861522 cites W1603793127 @default.
- W2004861522 cites W1608689696 @default.
- W2004861522 cites W1622325070 @default.
- W2004861522 cites W1874881634 @default.
- W2004861522 cites W1966332311 @default.
- W2004861522 cites W1967364632 @default.
- W2004861522 cites W1969454624 @default.
- W2004861522 cites W1973085375 @default.
- W2004861522 cites W1978032395 @default.
- W2004861522 cites W1978661875 @default.
- W2004861522 cites W1979605928 @default.
- W2004861522 cites W1985762385 @default.
- W2004861522 cites W1986858954 @default.
- W2004861522 cites W1988642004 @default.
- W2004861522 cites W1990452435 @default.
- W2004861522 cites W1994104851 @default.
- W2004861522 cites W1994197132 @default.
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- W2004861522 cites W1998475589 @default.
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- W2004861522 cites W2010318629 @default.
- W2004861522 cites W2010399610 @default.
- W2004861522 cites W2013284293 @default.
- W2004861522 cites W2017052599 @default.
- W2004861522 cites W2022936129 @default.
- W2004861522 cites W2023569481 @default.
- W2004861522 cites W2027652933 @default.
- W2004861522 cites W2031863792 @default.
- W2004861522 cites W2032145455 @default.
- W2004861522 cites W2039135332 @default.
- W2004861522 cites W2040328392 @default.
- W2004861522 cites W2040506727 @default.
- W2004861522 cites W2041816353 @default.
- W2004861522 cites W2050643804 @default.
- W2004861522 cites W2051181798 @default.
- W2004861522 cites W2065010826 @default.
- W2004861522 cites W2066264051 @default.
- W2004861522 cites W2067487392 @default.
- W2004861522 cites W2068690942 @default.
- W2004861522 cites W2069328568 @default.
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- W2004861522 cites W2079933835 @default.
- W2004861522 cites W2079961202 @default.
- W2004861522 cites W2083429893 @default.
- W2004861522 cites W2089483984 @default.
- W2004861522 cites W20935937 @default.
- W2004861522 cites W2093603211 @default.
- W2004861522 cites W2096083625 @default.
- W2004861522 cites W2097239500 @default.
- W2004861522 cites W2100597608 @default.
- W2004861522 cites W2106797333 @default.
- W2004861522 cites W2108005060 @default.
- W2004861522 cites W2110399580 @default.
- W2004861522 cites W2113717339 @default.
- W2004861522 cites W2128808414 @default.
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- W2004861522 cites W2143658931 @default.
- W2004861522 cites W2149294491 @default.
- W2004861522 cites W2149538815 @default.
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- W2004861522 cites W2168836733 @default.
- W2004861522 cites W2339422997 @default.
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- W2004861522 doi "https://doi.org/10.1016/j.yexcr.2011.09.013" @default.
- W2004861522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22001646" @default.
- W2004861522 hasPublicationYear "2011" @default.
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