Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004873892> ?p ?o ?g. }
- W2004873892 endingPage "876" @default.
- W2004873892 startingPage "869" @default.
- W2004873892 abstract "In the present study, we examined the involvement of the sigma(1) (sigma(1)) receptor in several behavioral manifestations of ethanol addiction. Administration of ethanol (0.5, 1, and 2 g/kg) in Swiss mice dose-dependently induced locomotor stimulation, conditioned place preference, and conditioned taste aversion, which are considered as behavioral index of drug-induced reward. Pretreatment with the selective sigma(1) receptor antagonist N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine (BD1047, 3-30 mg/kg) dose-dependently blocked ethanol (1 g/kg)-induced hyperlocomotion and taste aversion and ethanol (2 g/kg)-induced place preference. Pretreatment with the selective sigma(1) receptor agonist 2-(4-morpholino)ethyl 1-phenylcyclohexane-1-carboxylate (PRE-084, 1-10 mg/kg) before ethanol (0.5 g/kg) failed to affect the resulting locomotor stimulation, but dose-dependently enhanced the conditioned place preference. Each sigma(1) receptor ligand was devoid of behavioral effect by itself. These observations show that activation of the sigma(1) receptor is a necessary component of ethanol-induced motivational effects and suggest a new pharmacological target for alleviating ethanol addiction." @default.
- W2004873892 created "2016-06-24" @default.
- W2004873892 creator A5017018224 @default.
- W2004873892 creator A5044665810 @default.
- W2004873892 creator A5045510832 @default.
- W2004873892 creator A5053677344 @default.
- W2004873892 date "2003-03-01" @default.
- W2004873892 modified "2023-09-23" @default.
- W2004873892 title "Involvement of the sigma1 receptor in the motivational effects of ethanol in mice" @default.
- W2004873892 cites W1492673141 @default.
- W2004873892 cites W1874199142 @default.
- W2004873892 cites W1967507534 @default.
- W2004873892 cites W1970503530 @default.
- W2004873892 cites W1984110918 @default.
- W2004873892 cites W1984633643 @default.
- W2004873892 cites W1985530497 @default.
- W2004873892 cites W1986595272 @default.
- W2004873892 cites W1988973849 @default.
- W2004873892 cites W1990621985 @default.
- W2004873892 cites W1990626414 @default.
- W2004873892 cites W1992225421 @default.
- W2004873892 cites W1992336722 @default.
- W2004873892 cites W1994224293 @default.
- W2004873892 cites W1994745690 @default.
- W2004873892 cites W1995552213 @default.
- W2004873892 cites W1996751433 @default.
- W2004873892 cites W2000375437 @default.
- W2004873892 cites W2001865657 @default.
- W2004873892 cites W2006283790 @default.
- W2004873892 cites W2011766778 @default.
- W2004873892 cites W2012298500 @default.
- W2004873892 cites W2019242961 @default.
- W2004873892 cites W2023202438 @default.
- W2004873892 cites W2026692772 @default.
- W2004873892 cites W2030687244 @default.
- W2004873892 cites W2035141753 @default.
- W2004873892 cites W2035795104 @default.
- W2004873892 cites W2040395804 @default.
- W2004873892 cites W2045491661 @default.
- W2004873892 cites W2054597500 @default.
- W2004873892 cites W2067388722 @default.
- W2004873892 cites W2071668236 @default.
- W2004873892 cites W2078206616 @default.
- W2004873892 cites W2078309011 @default.
- W2004873892 cites W2085866328 @default.
- W2004873892 cites W2092428486 @default.
- W2004873892 cites W2122592499 @default.
- W2004873892 cites W2158161193 @default.
- W2004873892 cites W2165398609 @default.
- W2004873892 cites W2168343236 @default.
- W2004873892 cites W4231195547 @default.
- W2004873892 cites W4237673436 @default.
- W2004873892 doi "https://doi.org/10.1016/s0091-3057(03)00002-9" @default.
- W2004873892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12667901" @default.
- W2004873892 hasPublicationYear "2003" @default.
- W2004873892 type Work @default.
- W2004873892 sameAs 2004873892 @default.
- W2004873892 citedByCount "56" @default.
- W2004873892 countsByYear W20048738922012 @default.
- W2004873892 countsByYear W20048738922013 @default.
- W2004873892 countsByYear W20048738922015 @default.
- W2004873892 countsByYear W20048738922016 @default.
- W2004873892 countsByYear W20048738922017 @default.
- W2004873892 countsByYear W20048738922019 @default.
- W2004873892 countsByYear W20048738922020 @default.
- W2004873892 countsByYear W20048738922021 @default.
- W2004873892 countsByYear W20048738922022 @default.
- W2004873892 countsByYear W20048738922023 @default.
- W2004873892 crossrefType "journal-article" @default.
- W2004873892 hasAuthorship W2004873892A5017018224 @default.
- W2004873892 hasAuthorship W2004873892A5044665810 @default.
- W2004873892 hasAuthorship W2004873892A5045510832 @default.
- W2004873892 hasAuthorship W2004873892A5053677344 @default.
- W2004873892 hasConcept C15744967 @default.
- W2004873892 hasConcept C169760540 @default.
- W2004873892 hasConcept C170493617 @default.
- W2004873892 hasConcept C185592680 @default.
- W2004873892 hasConcept C24998067 @default.
- W2004873892 hasConcept C2776885963 @default.
- W2004873892 hasConcept C2777052854 @default.
- W2004873892 hasConcept C2778555786 @default.
- W2004873892 hasConcept C2778938600 @default.
- W2004873892 hasConcept C2780161600 @default.
- W2004873892 hasConcept C35124327 @default.
- W2004873892 hasConcept C48856860 @default.
- W2004873892 hasConcept C55493867 @default.
- W2004873892 hasConcept C71924100 @default.
- W2004873892 hasConcept C98274493 @default.
- W2004873892 hasConceptScore W2004873892C15744967 @default.
- W2004873892 hasConceptScore W2004873892C169760540 @default.
- W2004873892 hasConceptScore W2004873892C170493617 @default.
- W2004873892 hasConceptScore W2004873892C185592680 @default.
- W2004873892 hasConceptScore W2004873892C24998067 @default.
- W2004873892 hasConceptScore W2004873892C2776885963 @default.
- W2004873892 hasConceptScore W2004873892C2777052854 @default.
- W2004873892 hasConceptScore W2004873892C2778555786 @default.
- W2004873892 hasConceptScore W2004873892C2778938600 @default.
- W2004873892 hasConceptScore W2004873892C2780161600 @default.