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- W2004874493 abstract "Abstract Three insulin‐like growth factor (IGF‐1) sheep genetic selection lines (Low, Control and High) based on phenotypic IGF‐1 concentrations post‐weaning have previously shown a negative relationship between IGF‐1 concentration and lamb birth‐weight. The present study was designed to determine if dam nutritional regimen in late pregnancy affected this relationship. Nineteen Low, 66 Control and 51 High IGF‐1 selection line pregnant ewes were either offered a restricted or ad‐lib nutritional regimen from day 91 of pregnancy. The ewe nutritional regimens resulted in differences (P < 0.05) in ewe liveweight and condition score in late pregnancy. IGF‐1 concentrations of High and Low line ewes differed (P < 0.05) throughout the late‐pregnancy period with Control line concentrations being intermediate. In late pregnancy, ad‐lib ewes had higher (P < 0.05) IGF‐1 concentrations than restricted ewes. Neither IGF‐1 selection line or nutrition regimen consistently affected ewe glucose, non‐esterified fatty acids (NEFA), β‐hydroxybuterate or lactate concentrations. Under ad‐lib nutritional conditions the birthweights of High line lambs were lighter (P < 0.05) than Control lambs. This relationship was not observed under the restricted nutritional regimen. The interaction between IGF‐1 selection line and dam nutrition for lamb birthweight may explain the previously reported variability in the birthweight response between IGF‐1 selection lines. We speculate that under conditions of ad‐lib dam pregnancy nutrition, High IGF‐1 selection line ewes partition resources away from the placenta resulting in poorer foetal nutrition." @default.
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- W2004874493 date "2009-03-01" @default.
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- W2004874493 title "Late‐pregnancy nutrition differentially affects the birthweight of lambs born to ewes from divergently selected plasma IGF‐1 lines" @default.
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- W2004874493 doi "https://doi.org/10.1080/00288230909510484" @default.
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