Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004880491> ?p ?o ?g. }
- W2004880491 endingPage "118" @default.
- W2004880491 startingPage "112" @default.
- W2004880491 abstract "Ten years of translational research in breast cancer (BC) using high-throughput technologies such as cDNA arrays have produced an impressive amount of results. However, it is difficult for a single researcher to overview these results, since no critical synthesis is provided in the literature. This is a meta-analysis of gene expression in BC. Thirteen translational studies fulfilled the inclusion criteria, involving 553 BC patients and 79 controls. Large cohorts of patients and well-defined samples were rare. A total of 1,350 genes were reported at least once to be deregulated in BC. Out of these findings, 1,212 (90%) were not confirmed by other authors. A cohort of 138 genes of particular interest remained for further analysis. Of these, 79 were consistently reported to be overexpressed in BC, 41 to be underexpressed and in 18 cases results were contradictory. The most frequently reported deregulated genes in BC include: GATA binding protein 3, arylamine N-acetyltransferase, Myb-related protein B and zinc transporter SLC39A6 precursor (overexpressed); cadherin-3 precursor, keratin type I cytoskeletal 17 and type II cytoskeletal 5 (underexpressed). These genes obviously correlate with the presence and/or development of BC. More efforts should be devoted to the establishment of common standards in translational BC research." @default.
- W2004880491 created "2016-06-24" @default.
- W2004880491 creator A5044132148 @default.
- W2004880491 creator A5045015896 @default.
- W2004880491 creator A5069949021 @default.
- W2004880491 date "2008-01-01" @default.
- W2004880491 modified "2023-09-26" @default.
- W2004880491 title "Lost in Translation? A Systematic Database of Gene Expression in Breast Cancer" @default.
- W2004880491 cites W105210906 @default.
- W2004880491 cites W1520956379 @default.
- W2004880491 cites W1598130102 @default.
- W2004880491 cites W1860481841 @default.
- W2004880491 cites W1968772995 @default.
- W2004880491 cites W1977934858 @default.
- W2004880491 cites W1989995458 @default.
- W2004880491 cites W1998285877 @default.
- W2004880491 cites W1999463736 @default.
- W2004880491 cites W2000816383 @default.
- W2004880491 cites W2028395883 @default.
- W2004880491 cites W2039210770 @default.
- W2004880491 cites W2045382795 @default.
- W2004880491 cites W2061701570 @default.
- W2004880491 cites W2064619786 @default.
- W2004880491 cites W2068756214 @default.
- W2004880491 cites W2075292140 @default.
- W2004880491 cites W2093602249 @default.
- W2004880491 cites W2097255042 @default.
- W2004880491 cites W2097375063 @default.
- W2004880491 cites W2097384171 @default.
- W2004880491 cites W2120004030 @default.
- W2004880491 cites W2130134868 @default.
- W2004880491 cites W2131994307 @default.
- W2004880491 cites W2133105825 @default.
- W2004880491 cites W2134253888 @default.
- W2004880491 cites W2136029031 @default.
- W2004880491 cites W2137988967 @default.
- W2004880491 cites W2154361640 @default.
- W2004880491 cites W2157840751 @default.
- W2004880491 cites W2160450758 @default.
- W2004880491 cites W2163924299 @default.
- W2004880491 cites W2168561598 @default.
- W2004880491 cites W2169569769 @default.
- W2004880491 cites W2170140374 @default.
- W2004880491 cites W2417618303 @default.
- W2004880491 cites W2417632502 @default.
- W2004880491 doi "https://doi.org/10.1159/000123849" @default.
- W2004880491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18544966" @default.
- W2004880491 hasPublicationYear "2008" @default.
- W2004880491 type Work @default.
- W2004880491 sameAs 2004880491 @default.
- W2004880491 citedByCount "19" @default.
- W2004880491 countsByYear W20048804912012 @default.
- W2004880491 countsByYear W20048804912015 @default.
- W2004880491 countsByYear W20048804912018 @default.
- W2004880491 countsByYear W20048804912019 @default.
- W2004880491 countsByYear W20048804912021 @default.
- W2004880491 crossrefType "journal-article" @default.
- W2004880491 hasAuthorship W2004880491A5044132148 @default.
- W2004880491 hasAuthorship W2004880491A5045015896 @default.
- W2004880491 hasAuthorship W2004880491A5069949021 @default.
- W2004880491 hasBestOaLocation W20048804911 @default.
- W2004880491 hasConcept C104317684 @default.
- W2004880491 hasConcept C105580179 @default.
- W2004880491 hasConcept C121608353 @default.
- W2004880491 hasConcept C149364088 @default.
- W2004880491 hasConcept C150194340 @default.
- W2004880491 hasConcept C502942594 @default.
- W2004880491 hasConcept C530470458 @default.
- W2004880491 hasConcept C54355233 @default.
- W2004880491 hasConcept C60644358 @default.
- W2004880491 hasConcept C70721500 @default.
- W2004880491 hasConcept C86803240 @default.
- W2004880491 hasConceptScore W2004880491C104317684 @default.
- W2004880491 hasConceptScore W2004880491C105580179 @default.
- W2004880491 hasConceptScore W2004880491C121608353 @default.
- W2004880491 hasConceptScore W2004880491C149364088 @default.
- W2004880491 hasConceptScore W2004880491C150194340 @default.
- W2004880491 hasConceptScore W2004880491C502942594 @default.
- W2004880491 hasConceptScore W2004880491C530470458 @default.
- W2004880491 hasConceptScore W2004880491C54355233 @default.
- W2004880491 hasConceptScore W2004880491C60644358 @default.
- W2004880491 hasConceptScore W2004880491C70721500 @default.
- W2004880491 hasConceptScore W2004880491C86803240 @default.
- W2004880491 hasIssue "2" @default.
- W2004880491 hasLocation W20048804911 @default.
- W2004880491 hasLocation W20048804912 @default.
- W2004880491 hasOpenAccess W2004880491 @default.
- W2004880491 hasPrimaryLocation W20048804911 @default.
- W2004880491 hasRelatedWork W1991523530 @default.
- W2004880491 hasRelatedWork W2002128513 @default.
- W2004880491 hasRelatedWork W2009966535 @default.
- W2004880491 hasRelatedWork W2020824267 @default.
- W2004880491 hasRelatedWork W2031436818 @default.
- W2004880491 hasRelatedWork W2057739827 @default.
- W2004880491 hasRelatedWork W2075354549 @default.
- W2004880491 hasRelatedWork W2171277769 @default.
- W2004880491 hasRelatedWork W3191462603 @default.
- W2004880491 hasRelatedWork W2092874662 @default.