FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004886688> ?p ?o ?g. }

• W2004886688 endingPage "2768" @default.
• W2004886688 startingPage "2756" @default.
• W2004886688 abstract "Heterogeneity of central serotonin (5-HT) raphe neurons is suggested by numerous lines of evidence, but its genetic basis remains elusive. The transcription factor Pet1 is required for the acquisition of serotonergic identity in a majority of neurons in the raphe nuclei. Nevertheless, a subset of 5-HT neurons differentiates in Pet1 knock-out mice. We show here that these residual 5-HT neurons outline a unique subpopulation of raphe neurons with highly selective anatomical targets and characteristic synaptic differentiations. In Pet1 knock-out mice, 5-HT innervation strikingly outlines the brain areas involved in stress responses with dense innervation to the basolateral amygdala, the paraventricular nucleus of the hypothalamus, and the intralaminar thalamic nuclei. In these regions, 5-HT terminals establish asymmetric synaptic junctions. This target selectivity could not be related to altered growth of the remaining 5-HT neurons, as indicated by axon tracing and cell culture analyses. The residual 5-HT axon terminals are functional with maintained release properties in vitro and in vivo. The functional consequence of this uneven distribution of 5-HT innervation on behavior was characterized. Pet1 knock-out mice showed decreased anxiety behavior in novelty exploration and increased fear responses to conditioned aversive cues. Overall, our findings lead us to propose the existence of Pet1-dependent and Pet1-resistant 5-HT neurons targeting different brain centers that might delineate the anatomical basis for a dual serotonergic control on stress responses." @default.
• W2004886688 created "2016-06-24" @default.
• W2004886688 creator A5001545848 @default.
• W2004886688 creator A5019270538 @default.
• W2004886688 creator A5023390247 @default.
• W2004886688 creator A5051062120 @default.
• W2004886688 creator A5053633010 @default.
• W2004886688 creator A5085217344 @default.
• W2004886688 creator A5086509913 @default.
• W2004886688 date "2011-02-23" @default.
• W2004886688 modified "2023-10-10" @default.
• W2004886688 title "A Genetically Defined Morphologically and Functionally Unique Subset of 5-HT Neurons in the Mouse Raphe Nuclei" @default.
• W2004886688 cites W138821745 @default.
• W2004886688 cites W1482114328 @default.
• W2004886688 cites W1520014704 @default.
• W2004886688 cites W1591919468 @default.
• W2004886688 cites W1602497443 @default.
• W2004886688 cites W1828538530 @default.
• W2004886688 cites W1891846574 @default.
• W2004886688 cites W1914747759 @default.
• W2004886688 cites W1973874549 @default.
• W2004886688 cites W1974052352 @default.
• W2004886688 cites W1988800128 @default.
• W2004886688 cites W1990545433 @default.
• W2004886688 cites W1991974510 @default.
• W2004886688 cites W1992116689 @default.
• W2004886688 cites W1994768518 @default.
• W2004886688 cites W1998712336 @default.
• W2004886688 cites W1999011552 @default.
• W2004886688 cites W2006573555 @default.
• W2004886688 cites W2012729010 @default.
• W2004886688 cites W2024628648 @default.
• W2004886688 cites W2025930929 @default.
• W2004886688 cites W2030187260 @default.
• W2004886688 cites W2033103225 @default.
• W2004886688 cites W2033467951 @default.
• W2004886688 cites W2034071775 @default.
• W2004886688 cites W2034951640 @default.
• W2004886688 cites W2039338324 @default.
• W2004886688 cites W2040763671 @default.
• W2004886688 cites W2041052894 @default.
• W2004886688 cites W2045171964 @default.
• W2004886688 cites W2046960533 @default.
• W2004886688 cites W2047494050 @default.
• W2004886688 cites W2051541361 @default.
• W2004886688 cites W2052784390 @default.
• W2004886688 cites W2055135519 @default.
• W2004886688 cites W2057352698 @default.
• W2004886688 cites W2057378152 @default.
• W2004886688 cites W2072268612 @default.
• W2004886688 cites W2073679038 @default.
• W2004886688 cites W2073866710 @default.
• W2004886688 cites W2074425528 @default.
• W2004886688 cites W2075464370 @default.
• W2004886688 cites W2080867987 @default.
• W2004886688 cites W2081784716 @default.
• W2004886688 cites W2085332671 @default.
• W2004886688 cites W2086972936 @default.
• W2004886688 cites W2091196304 @default.
• W2004886688 cites W2097589576 @default.
• W2004886688 cites W2098163527 @default.
• W2004886688 cites W2100693671 @default.
• W2004886688 cites W2106947309 @default.
• W2004886688 cites W2108879902 @default.
• W2004886688 cites W2111178305 @default.
• W2004886688 cites W2114773717 @default.
• W2004886688 cites W2119084915 @default.
• W2004886688 cites W2136387223 @default.
• W2004886688 cites W2138455429 @default.
• W2004886688 cites W2142771373 @default.
• W2004886688 cites W2152069082 @default.
• W2004886688 cites W2159612818 @default.
• W2004886688 cites W2171055927 @default.
• W2004886688 cites W2171786302 @default.
• W2004886688 cites W2192628338 @default.
• W2004886688 cites W2285774466 @default.
• W2004886688 cites W2334366741 @default.
• W2004886688 cites W64718845 @default.
• W2004886688 doi "https://doi.org/10.1523/jneurosci.4080-10.2011" @default.
• W2004886688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6623784" @default.
• W2004886688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21414898" @default.
• W2004886688 hasPublicationYear "2011" @default.
• W2004886688 type Work @default.
• W2004886688 sameAs 2004886688 @default.
• W2004886688 citedByCount "124" @default.
• W2004886688 countsByYear W20048866882012 @default.
• W2004886688 countsByYear W20048866882013 @default.
• W2004886688 countsByYear W20048866882014 @default.
• W2004886688 countsByYear W20048866882015 @default.
• W2004886688 countsByYear W20048866882016 @default.
• W2004886688 countsByYear W20048866882017 @default.
• W2004886688 countsByYear W20048866882018 @default.
• W2004886688 countsByYear W20048866882019 @default.
• W2004886688 countsByYear W20048866882020 @default.
• W2004886688 countsByYear W20048866882021 @default.
• W2004886688 countsByYear W20048866882022 @default.
• W2004886688 countsByYear W20048866882023 @default.
• W2004886688 crossrefType "journal-article" @default.

• next