Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004891612> ?p ?o ?g. }
- W2004891612 endingPage "186" @default.
- W2004891612 startingPage "179" @default.
- W2004891612 abstract "Targeted therapy using small-molecule inhibitors is a promising new therapy approach against cancer, but drug-resistant mutants present an obstacle to success. Oncolytic virus therapy, where viruses replicate specifically in cancer cells and kill them, is another promising therapy approach against cancer. While encouraging results have been observed in clinical trials, consistent success has not been possible so far. Based on a computational framework, I report that even if oncolytic virus therapy fails to eradicate a cancer, it can have the potential to eradicate the sub-population of drug-resistant cancer cells. Once this has occurred, targeted drug therapy can be used to induce cancer remission. For this to work, a drug resistance mutation must confer a certain fitness cost to the cell, as has been documented in the literature. The reason for this finding is that in the presence of a shared virus, the faster growing (drug-sensitive) cell population produces an amount of virus that is too much for the slower growing (drug-resistant) cell population to survive. This is derived from a population dynamic principle known as apparent competition. Therefore, a sequential combination of oncolytic virus and targeted therapies can overcome major weaknesses of either approach alone." @default.
- W2004891612 created "2016-06-24" @default.
- W2004891612 creator A5089070170 @default.
- W2004891612 date "2008-07-29" @default.
- W2004891612 modified "2023-09-24" @default.
- W2004891612 title "Use of oncolytic viruses for the eradication of drug-resistant cancer cells" @default.
- W2004891612 cites W120597284 @default.
- W2004891612 cites W131285836 @default.
- W2004891612 cites W1607745684 @default.
- W2004891612 cites W1674171460 @default.
- W2004891612 cites W1857344328 @default.
- W2004891612 cites W1963483847 @default.
- W2004891612 cites W1971055997 @default.
- W2004891612 cites W1973004691 @default.
- W2004891612 cites W1979254460 @default.
- W2004891612 cites W1980695222 @default.
- W2004891612 cites W1981218816 @default.
- W2004891612 cites W1982306896 @default.
- W2004891612 cites W1986969117 @default.
- W2004891612 cites W1999614615 @default.
- W2004891612 cites W2006917576 @default.
- W2004891612 cites W2010349266 @default.
- W2004891612 cites W2010365240 @default.
- W2004891612 cites W2011715147 @default.
- W2004891612 cites W2013023971 @default.
- W2004891612 cites W2016470320 @default.
- W2004891612 cites W2016656445 @default.
- W2004891612 cites W2020164940 @default.
- W2004891612 cites W2024882325 @default.
- W2004891612 cites W2032471469 @default.
- W2004891612 cites W2033659551 @default.
- W2004891612 cites W2045630377 @default.
- W2004891612 cites W2045950514 @default.
- W2004891612 cites W2046933315 @default.
- W2004891612 cites W2051515879 @default.
- W2004891612 cites W2052792754 @default.
- W2004891612 cites W2063512646 @default.
- W2004891612 cites W2065867768 @default.
- W2004891612 cites W2069741650 @default.
- W2004891612 cites W2070851032 @default.
- W2004891612 cites W2075548587 @default.
- W2004891612 cites W2080410270 @default.
- W2004891612 cites W2081689148 @default.
- W2004891612 cites W2082580993 @default.
- W2004891612 cites W2086344594 @default.
- W2004891612 cites W2090732350 @default.
- W2004891612 cites W2094556422 @default.
- W2004891612 cites W2102610315 @default.
- W2004891612 cites W2137742633 @default.
- W2004891612 cites W2139097830 @default.
- W2004891612 cites W2157277269 @default.
- W2004891612 cites W2161116475 @default.
- W2004891612 cites W2169331901 @default.
- W2004891612 cites W2242273658 @default.
- W2004891612 cites W2317901346 @default.
- W2004891612 cites W2323339614 @default.
- W2004891612 cites W2335339954 @default.
- W2004891612 doi "https://doi.org/10.1098/rsif.2008.0191" @default.
- W2004891612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2658788" @default.
- W2004891612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18664430" @default.
- W2004891612 hasPublicationYear "2008" @default.
- W2004891612 type Work @default.
- W2004891612 sameAs 2004891612 @default.
- W2004891612 citedByCount "17" @default.
- W2004891612 countsByYear W20048916122012 @default.
- W2004891612 countsByYear W20048916122013 @default.
- W2004891612 countsByYear W20048916122014 @default.
- W2004891612 countsByYear W20048916122016 @default.
- W2004891612 countsByYear W20048916122019 @default.
- W2004891612 countsByYear W20048916122020 @default.
- W2004891612 countsByYear W20048916122021 @default.
- W2004891612 crossrefType "journal-article" @default.
- W2004891612 hasAuthorship W2004891612A5089070170 @default.
- W2004891612 hasBestOaLocation W20048916122 @default.
- W2004891612 hasConcept C114851261 @default.
- W2004891612 hasConcept C121608353 @default.
- W2004891612 hasConcept C159047783 @default.
- W2004891612 hasConcept C2522874641 @default.
- W2004891612 hasConcept C2780035454 @default.
- W2004891612 hasConcept C2908647359 @default.
- W2004891612 hasConcept C3020340455 @default.
- W2004891612 hasConcept C54355233 @default.
- W2004891612 hasConcept C71924100 @default.
- W2004891612 hasConcept C82210918 @default.
- W2004891612 hasConcept C86803240 @default.
- W2004891612 hasConcept C89423630 @default.
- W2004891612 hasConcept C98274493 @default.
- W2004891612 hasConcept C99454951 @default.
- W2004891612 hasConceptScore W2004891612C114851261 @default.
- W2004891612 hasConceptScore W2004891612C121608353 @default.
- W2004891612 hasConceptScore W2004891612C159047783 @default.
- W2004891612 hasConceptScore W2004891612C2522874641 @default.
- W2004891612 hasConceptScore W2004891612C2780035454 @default.
- W2004891612 hasConceptScore W2004891612C2908647359 @default.
- W2004891612 hasConceptScore W2004891612C3020340455 @default.
- W2004891612 hasConceptScore W2004891612C54355233 @default.
- W2004891612 hasConceptScore W2004891612C71924100 @default.
- W2004891612 hasConceptScore W2004891612C82210918 @default.