FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004891851> ?p ?o ?g. }

• W2004891851 endingPage "453" @default.
• W2004891851 startingPage "446" @default.
• W2004891851 abstract "Inorganic arsenic (iAs) [As(III)+As(V)] is a drinking water contaminant, and human exposure to these arsenic species has been linked with a wide range of health effects. The main path of exposure is the oral route, and the intestinal epithelium is the first physiological barrier that iAs must cross in order to be absorbed. However, there is a lack of information about intestinal iAs absorption. The aim of this study was to evaluate the participation of certain transporters [glucose transporters (GLUT and SGLT), organic anion transporting polypeptides (OATPs), aquaporins (AQPs), and phosphate transporters (NaPi and PiT)] in intestinal absorption of As(V) and As(III), using the Caco-2 cell line as a model of the intestinal epithelium. For this purpose, the effects of chemical inhibition and gene silencing of the transporters of interest on iAs uptake were evaluated, and also the differential expression of these transporters after treatment with iAs. The results show that chemical inhibition using rifamycin SV (OATP inhibitor), phloridzin (SGLT inhibitor), phloretin (GLUT and AQP inhibitor), and copper sulfate (AQP inhibitor) leads to a significant reduction in the apparent permeability and cellular retention of As(III). RT-qPCR indicates up-regulation of GLUT2, GLUT5, OATPB, AQP3, and AQP10 after exposure to As(III), while exposure to As(V) increases the expression of sodium-dependent phosphate transporters, especially NaPiIIb. Gene silencing of OATPB, AQP10, and GLUT5 for As(III) and NaPiIIb for As(V) significantly reduces uptake of the inorganic forms. These results indicate that these transporters may be involved in intestinal absorption of iAs." @default.
• W2004891851 created "2016-06-24" @default.
• W2004891851 creator A5017143150 @default.
• W2004891851 creator A5063470813 @default.
• W2004891851 creator A5075376051 @default.
• W2004891851 creator A5083118590 @default.
• W2004891851 date "2012-01-26" @default.
• W2004891851 modified "2023-09-23" @default.
• W2004891851 title "In Vitro Study of Transporters Involved in Intestinal Absorption of Inorganic Arsenic" @default.
• W2004891851 cites W1257903918 @default.
• W2004891851 cites W188478155 @default.
• W2004891851 cites W1911285871 @default.
• W2004891851 cites W1956777900 @default.
• W2004891851 cites W1965883223 @default.
• W2004891851 cites W1978116407 @default.
• W2004891851 cites W1995291627 @default.
• W2004891851 cites W1995526845 @default.
• W2004891851 cites W2003197024 @default.
• W2004891851 cites W2004237350 @default.
• W2004891851 cites W2010409177 @default.
• W2004891851 cites W2015977579 @default.
• W2004891851 cites W2020166925 @default.
• W2004891851 cites W2023422717 @default.
• W2004891851 cites W2027307634 @default.
• W2004891851 cites W2051483612 @default.
• W2004891851 cites W2051785676 @default.
• W2004891851 cites W2053474597 @default.
• W2004891851 cites W2062013076 @default.
• W2004891851 cites W2067740062 @default.
• W2004891851 cites W2068192558 @default.
• W2004891851 cites W2068406006 @default.
• W2004891851 cites W2068934404 @default.
• W2004891851 cites W2072923159 @default.
• W2004891851 cites W2073985048 @default.
• W2004891851 cites W2086201153 @default.
• W2004891851 cites W2087900496 @default.
• W2004891851 cites W2092910855 @default.
• W2004891851 cites W2099376629 @default.
• W2004891851 cites W2105125296 @default.
• W2004891851 cites W2107062504 @default.
• W2004891851 cites W2136894605 @default.
• W2004891851 cites W2150293665 @default.
• W2004891851 cites W2154009044 @default.
• W2004891851 cites W2154223973 @default.
• W2004891851 cites W2165623787 @default.
• W2004891851 cites W2187030923 @default.
• W2004891851 cites W2264715249 @default.
• W2004891851 cites W2287639915 @default.
• W2004891851 cites W236740644 @default.
• W2004891851 doi "https://doi.org/10.1021/tx200491f" @default.
• W2004891851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22214486" @default.
• W2004891851 hasPublicationYear "2012" @default.
• W2004891851 type Work @default.
• W2004891851 sameAs 2004891851 @default.
• W2004891851 citedByCount "69" @default.
• W2004891851 countsByYear W20048918512012 @default.
• W2004891851 countsByYear W20048918512013 @default.
• W2004891851 countsByYear W20048918512014 @default.
• W2004891851 countsByYear W20048918512015 @default.
• W2004891851 countsByYear W20048918512016 @default.
• W2004891851 countsByYear W20048918512017 @default.
• W2004891851 countsByYear W20048918512018 @default.
• W2004891851 countsByYear W20048918512019 @default.
• W2004891851 countsByYear W20048918512020 @default.
• W2004891851 countsByYear W20048918512021 @default.
• W2004891851 countsByYear W20048918512022 @default.
• W2004891851 countsByYear W20048918512023 @default.
• W2004891851 crossrefType "journal-article" @default.
• W2004891851 hasAuthorship W2004891851A5017143150 @default.
• W2004891851 hasAuthorship W2004891851A5063470813 @default.
• W2004891851 hasAuthorship W2004891851A5075376051 @default.
• W2004891851 hasAuthorship W2004891851A5083118590 @default.
• W2004891851 hasConcept C104317684 @default.
• W2004891851 hasConcept C134018914 @default.
• W2004891851 hasConcept C149011108 @default.
• W2004891851 hasConcept C150194340 @default.
• W2004891851 hasConcept C161573976 @default.
• W2004891851 hasConcept C185592680 @default.
• W2004891851 hasConcept C200082930 @default.
• W2004891851 hasConcept C2777901630 @default.
• W2004891851 hasConcept C2778423325 @default.
• W2004891851 hasConcept C2779306644 @default.
• W2004891851 hasConcept C55493867 @default.
• W2004891851 hasConcept C86803240 @default.
• W2004891851 hasConcept C98274493 @default.
• W2004891851 hasConceptScore W2004891851C104317684 @default.
• W2004891851 hasConceptScore W2004891851C134018914 @default.
• W2004891851 hasConceptScore W2004891851C149011108 @default.
• W2004891851 hasConceptScore W2004891851C150194340 @default.
• W2004891851 hasConceptScore W2004891851C161573976 @default.
• W2004891851 hasConceptScore W2004891851C185592680 @default.
• W2004891851 hasConceptScore W2004891851C200082930 @default.
• W2004891851 hasConceptScore W2004891851C2777901630 @default.
• W2004891851 hasConceptScore W2004891851C2778423325 @default.
• W2004891851 hasConceptScore W2004891851C2779306644 @default.
• W2004891851 hasConceptScore W2004891851C55493867 @default.
• W2004891851 hasConceptScore W2004891851C86803240 @default.
• W2004891851 hasConceptScore W2004891851C98274493 @default.

• next