Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004891896> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2004891896 endingPage "20" @default.
- W2004891896 startingPage "14" @default.
- W2004891896 abstract "Flavonoids have low bioavailabilities due to extensive intestinal first-pass metabolisms, especially glucuronidation. The present study aimed to evaluate the intestinal glucuronidation of dihydroxyflavones and provide more information on their structure–activity relationships. Seven dihydroxyflavones, namely 3,7-, 5,7-, 6,7-, 7,8-, 2′,7-, 3′,7-, and 4′,7-dihydroxyflaovne and a monohydroxyflavone, 7-hydroxyflavone, were investigated by incubating each hydroxyflavone at various concentrations with either human jejunum microsome or rat intestinal microsome. Two mono-glucuronides were identified for each dihydroxyflavone. For human jejunum microsome, most of the studied dihydroxyflavones demonstrated greater glucuronidation activities than that of 7-hydroxyflavone except for 3,7-dihydroxyflavone and 4′,7-dihydroxyflavone. 3′,7-dihydroxyflavone had the greatest intrinsic clearance which was at least seven times greater than that of all other dihydroxyflavones. In addition, species difference in glucuronidation activity was observed with human jejunum microsome higher than rat intestinal microsome for all hydroxyflavones except for 3,7-dihydroxyflavone. The results further demonstrated that the hydroxyl group positions do affect the intestinal glucuronidation activity of hydroxyflavones. Increasing the number of hydroxyl groups on A- or B-ring (except for 4′-OH) would enhance the glucuronidation activity of flavones, whereas adding a 3-OH on C-ring might not. Furthermore, existence of hydroxyl group at 3′ position may enhance the glucuronidation activity of flavonoids." @default.
- W2004891896 created "2016-06-24" @default.
- W2004891896 creator A5037975759 @default.
- W2004891896 creator A5047540439 @default.
- W2004891896 creator A5066716873 @default.
- W2004891896 creator A5081004832 @default.
- W2004891896 date "2009-01-01" @default.
- W2004891896 modified "2023-09-24" @default.
- W2004891896 title "Intestinal first-pass glucuronidation activities of selected dihydroxyflavones" @default.
- W2004891896 cites W144983782 @default.
- W2004891896 cites W1944481812 @default.
- W2004891896 cites W1968257455 @default.
- W2004891896 cites W1970221032 @default.
- W2004891896 cites W1976421128 @default.
- W2004891896 cites W1986699902 @default.
- W2004891896 cites W1990960628 @default.
- W2004891896 cites W1991048885 @default.
- W2004891896 cites W1993006528 @default.
- W2004891896 cites W2000369238 @default.
- W2004891896 cites W2000889074 @default.
- W2004891896 cites W2012783165 @default.
- W2004891896 cites W2046650127 @default.
- W2004891896 cites W2064388529 @default.
- W2004891896 cites W2077957170 @default.
- W2004891896 cites W2102513234 @default.
- W2004891896 cites W2110482855 @default.
- W2004891896 cites W2118292221 @default.
- W2004891896 cites W2123788796 @default.
- W2004891896 cites W2139632801 @default.
- W2004891896 cites W2165669901 @default.
- W2004891896 cites W2329983604 @default.
- W2004891896 doi "https://doi.org/10.1016/j.ijpharm.2008.08.035" @default.
- W2004891896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18809479" @default.
- W2004891896 hasPublicationYear "2009" @default.
- W2004891896 type Work @default.
- W2004891896 sameAs 2004891896 @default.
- W2004891896 citedByCount "22" @default.
- W2004891896 countsByYear W20048918962012 @default.
- W2004891896 countsByYear W20048918962014 @default.
- W2004891896 countsByYear W20048918962015 @default.
- W2004891896 countsByYear W20048918962016 @default.
- W2004891896 countsByYear W20048918962017 @default.
- W2004891896 countsByYear W20048918962018 @default.
- W2004891896 countsByYear W20048918962019 @default.
- W2004891896 countsByYear W20048918962022 @default.
- W2004891896 countsByYear W20048918962023 @default.
- W2004891896 crossrefType "journal-article" @default.
- W2004891896 hasAuthorship W2004891896A5037975759 @default.
- W2004891896 hasAuthorship W2004891896A5047540439 @default.
- W2004891896 hasAuthorship W2004891896A5066716873 @default.
- W2004891896 hasAuthorship W2004891896A5081004832 @default.
- W2004891896 hasConcept C181199279 @default.
- W2004891896 hasConcept C185592680 @default.
- W2004891896 hasConcept C2776292868 @default.
- W2004891896 hasConcept C2776366702 @default.
- W2004891896 hasConcept C2776524530 @default.
- W2004891896 hasConcept C2779907587 @default.
- W2004891896 hasConcept C43617362 @default.
- W2004891896 hasConcept C55493867 @default.
- W2004891896 hasConcept C86803240 @default.
- W2004891896 hasConcept C87644729 @default.
- W2004891896 hasConcept C98274493 @default.
- W2004891896 hasConceptScore W2004891896C181199279 @default.
- W2004891896 hasConceptScore W2004891896C185592680 @default.
- W2004891896 hasConceptScore W2004891896C2776292868 @default.
- W2004891896 hasConceptScore W2004891896C2776366702 @default.
- W2004891896 hasConceptScore W2004891896C2776524530 @default.
- W2004891896 hasConceptScore W2004891896C2779907587 @default.
- W2004891896 hasConceptScore W2004891896C43617362 @default.
- W2004891896 hasConceptScore W2004891896C55493867 @default.
- W2004891896 hasConceptScore W2004891896C86803240 @default.
- W2004891896 hasConceptScore W2004891896C87644729 @default.
- W2004891896 hasConceptScore W2004891896C98274493 @default.
- W2004891896 hasIssue "1-2" @default.
- W2004891896 hasLocation W20048918961 @default.
- W2004891896 hasLocation W20048918962 @default.
- W2004891896 hasOpenAccess W2004891896 @default.
- W2004891896 hasPrimaryLocation W20048918961 @default.
- W2004891896 hasRelatedWork W2004891896 @default.
- W2004891896 hasRelatedWork W2019270528 @default.
- W2004891896 hasRelatedWork W2032485237 @default.
- W2004891896 hasRelatedWork W2090753188 @default.
- W2004891896 hasRelatedWork W2091471909 @default.
- W2004891896 hasRelatedWork W2142771218 @default.
- W2004891896 hasRelatedWork W2143111336 @default.
- W2004891896 hasRelatedWork W2159372397 @default.
- W2004891896 hasRelatedWork W2352707564 @default.
- W2004891896 hasRelatedWork W4248825631 @default.
- W2004891896 hasVolume "366" @default.
- W2004891896 isParatext "false" @default.
- W2004891896 isRetracted "false" @default.
- W2004891896 magId "2004891896" @default.
- W2004891896 workType "article" @default.