FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004895532> ?p ?o ?g. }

• W2004895532 endingPage "e88369" @default.
• W2004895532 startingPage "e88369" @default.
• W2004895532 abstract "It has been suggested that prolonged inflammatory bowel diseases (IBD) may lead to colitis-associated carcinogenesis (CAC). We previously observed that the NF-κB activation in colonic epithelial cells is associated with increased tumor necrosis factor receptor 2 (TNFR2) expression in CAC development. However, the mechanism by which epithelial NF-κB activation leading to CAC is still unclear. Myosin light chain kinase (MLCK) has been reported to be responsible for the epithelial permeability associated with TNF signaling. Therefore we focused on the role of MLCK expression via TNFR2 signaling on CAC development. Pro-tumorigenic cytokines such as IL-1β, IL-6 and MIP-2 production as well as INF-γ and TNF production at the lamina propria were increased in the setting of colitis, and further in tumor tissues in associations with up-regulated TNFR2 and MLCK expressions in the epithelial cells of a CAC model. The up-regulated MLCK expression was observed in TNF-stimulated colonic epithelial cells in a dose-dependent fashion in association with up-regulation of TNFR2. Silencing TNFR2, but not TNFR1, resulted in restoration of epithelial tight junction (TJ) associated with decreased MLCK expression. Antibody-mediated blockade of TNF signaling also resulted in restoration of TJ in association with suppressed MLCK expression, and interestingly, similar results were observed with suppressing TNFR2 and MLCK expressions by inhibiting MLCK in the epithelial cells. Silencing of MLCK also resulted in suppressed TNFR2, but not TNFR1, expression, suggesting that the restored TJ leads to reduced TNFR2 signaling. Such suppression of MLCK as well as blockade of TNFR2 signaling resulted in restored TJ, decreased pro-tumorigenic cytokines and reduced CAC development. These results suggest that MLCK may be a potential target for the prevention of IBD-associated tumor development." @default.
• W2004895532 created "2016-06-24" @default.
• W2004895532 creator A5001049289 @default.
• W2004895532 creator A5002316853 @default.
• W2004895532 creator A5018914730 @default.
• W2004895532 creator A5025943318 @default.
• W2004895532 creator A5030148991 @default.
• W2004895532 creator A5040680041 @default.
• W2004895532 creator A5045376146 @default.
• W2004895532 creator A5056873611 @default.
• W2004895532 creator A5057817047 @default.
• W2004895532 creator A5064010379 @default.
• W2004895532 creator A5070494006 @default.
• W2004895532 creator A5076002314 @default.
• W2004895532 creator A5088773176 @default.
• W2004895532 creator A5090861553 @default.
• W2004895532 date "2014-02-10" @default.
• W2004895532 modified "2023-10-11" @default.
• W2004895532 title "Myosin Light Chain Kinase Expression Induced via Tumor Necrosis Factor Receptor 2 Signaling in the Epithelial Cells Regulates the Development of Colitis-Associated Carcinogenesis" @default.
• W2004895532 cites W1516032939 @default.
• W2004895532 cites W1613868394 @default.
• W2004895532 cites W1640670825 @default.
• W2004895532 cites W1663011875 @default.
• W2004895532 cites W1668613481 @default.
• W2004895532 cites W1856081267 @default.
• W2004895532 cites W1965037168 @default.
• W2004895532 cites W1972464426 @default.
• W2004895532 cites W1972899659 @default.
• W2004895532 cites W1975864305 @default.
• W2004895532 cites W1983552305 @default.
• W2004895532 cites W1985082045 @default.
• W2004895532 cites W1990970592 @default.
• W2004895532 cites W1995646479 @default.
• W2004895532 cites W2005553679 @default.
• W2004895532 cites W2011753823 @default.
• W2004895532 cites W2025451832 @default.
• W2004895532 cites W2025981951 @default.
• W2004895532 cites W2026116536 @default.
• W2004895532 cites W2029790299 @default.
• W2004895532 cites W2039632779 @default.
• W2004895532 cites W2041455780 @default.
• W2004895532 cites W2041838266 @default.
• W2004895532 cites W2042606716 @default.
• W2004895532 cites W2055222262 @default.
• W2004895532 cites W2055582579 @default.
• W2004895532 cites W2056924037 @default.
• W2004895532 cites W2057026940 @default.
• W2004895532 cites W2064794064 @default.
• W2004895532 cites W2079046187 @default.
• W2004895532 cites W2092273659 @default.
• W2004895532 cites W2097929425 @default.
• W2004895532 cites W2101229561 @default.
• W2004895532 cites W2124076790 @default.
• W2004895532 cites W2133560683 @default.
• W2004895532 cites W2160401081 @default.
• W2004895532 cites W2171297959 @default.
• W2004895532 cites W2171341132 @default.
• W2004895532 cites W2177396386 @default.
• W2004895532 cites W2321453230 @default.
• W2004895532 cites W2614197161 @default.
• W2004895532 cites W4234288885 @default.
• W2004895532 doi "https://doi.org/10.1371/journal.pone.0088369" @default.
• W2004895532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3919773" @default.
• W2004895532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24520376" @default.
• W2004895532 hasPublicationYear "2014" @default.
• W2004895532 type Work @default.
• W2004895532 sameAs 2004895532 @default.
• W2004895532 citedByCount "42" @default.
• W2004895532 countsByYear W20048955322015 @default.
• W2004895532 countsByYear W20048955322016 @default.
• W2004895532 countsByYear W20048955322017 @default.
• W2004895532 countsByYear W20048955322018 @default.
• W2004895532 countsByYear W20048955322019 @default.
• W2004895532 countsByYear W20048955322020 @default.
• W2004895532 countsByYear W20048955322021 @default.
• W2004895532 countsByYear W20048955322022 @default.
• W2004895532 countsByYear W20048955322023 @default.
• W2004895532 crossrefType "journal-article" @default.
• W2004895532 hasAuthorship W2004895532A5001049289 @default.
• W2004895532 hasAuthorship W2004895532A5002316853 @default.
• W2004895532 hasAuthorship W2004895532A5018914730 @default.
• W2004895532 hasAuthorship W2004895532A5025943318 @default.
• W2004895532 hasAuthorship W2004895532A5030148991 @default.
• W2004895532 hasAuthorship W2004895532A5040680041 @default.
• W2004895532 hasAuthorship W2004895532A5045376146 @default.
• W2004895532 hasAuthorship W2004895532A5056873611 @default.
• W2004895532 hasAuthorship W2004895532A5057817047 @default.
• W2004895532 hasAuthorship W2004895532A5064010379 @default.
• W2004895532 hasAuthorship W2004895532A5070494006 @default.
• W2004895532 hasAuthorship W2004895532A5076002314 @default.
• W2004895532 hasAuthorship W2004895532A5088773176 @default.
• W2004895532 hasAuthorship W2004895532A5090861553 @default.
• W2004895532 hasBestOaLocation W20048955321 @default.
• W2004895532 hasConcept C104317684 @default.
• W2004895532 hasConcept C119056186 @default.
• W2004895532 hasConcept C17991360 @default.
• W2004895532 hasConcept C185592680 @default.
• W2004895532 hasConcept C203014093 @default.

• next