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- W2004896472 abstract "The present study determined if chronic simvastatin administration in vivo would provide neuroprotection in brain cells isolated from guinea pigs after challenge with the Bcl-2 inhibitor HA 14-1 or the NO donor sodium nitroprusside (SNP). Bcl-2 levels were significantly increased in brains of simvastatin-treated guinea pigs while levels of the pro-apoptotic protein Bax were significantly reduced. The ratio of Bax/Bcl-2, being a critical factor of the apoptotic state of cells, was significantly reduced in simvastatin-treated animals. Cholesterol levels in the brain remained unchanged in the simvastatin group. Brain cells isolated from simvastatin-treated guinea pigs were significantly less vulnerable to mitochondrial dysfunction and caspase-activation. These results provide new insight into potential mechanisms for the protective actions of statins within the CNS where programmed cell death has been implicated." @default.
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- W2004896472 date "2007-02-01" @default.
- W2004896472 modified "2023-09-23" @default.
- W2004896472 title "Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment" @default.
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- W2004896472 doi "https://doi.org/10.1016/j.nbd.2006.10.004" @default.
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