Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004902484> ?p ?o ?g. }
- W2004902484 endingPage "4300" @default.
- W2004902484 startingPage "4291" @default.
- W2004902484 abstract "Abstract The insulin response element (IRE) of the human insulin-like growth factor-binding protein-1 (IGFBP-1) promoter contains a palindrome of the T(A/G)TTT sequence crucial to hormonal regulation of many genes. In initial studies of how this IRE participates in hormonal regulation, the electromobility shift assay was used under a variety of conditions to identify IRE-binding proteins. An exhaustive search identified five proteins that specifically bind this IRE; purified proteins were used to show that all five are related to either the high mobility group I/Y (HMGI/Y) or hepatic nuclear factor 3 (HNF3) protein families. Further studies used purified HNF3 and HMGI proteins to show: 1) each protects the IGFBP-1 IRE from deoxyribonuclease I (DNaseI) digestion; and 2) HNF3 but not HMGI/Y binds to the related phosphoenolpyruvate carboxykinase and Apo CIII IREs. A series of IRE mutants with variable responsiveness to insulin were used to show that the presence of a TGTTT sequence in the mutants did parallel, but HMGI/Y and HNF3 binding to the mutants did not parallel, the ability of the mutants to confer the inhibitory effect of insulin. In contrast, HNF3 binding to these IRE mutants roughly correlates with response of the mutants to glucocorticoids. The way by which HNF3 and/or other as yet unidentified IRE-binding proteins confer insulin inhibition to IGFBP-1 transcription and the role of HMGI/Y in IRE function have yet to be established." @default.
- W2004902484 created "2016-06-24" @default.
- W2004902484 creator A5007435264 @default.
- W2004902484 creator A5011062127 @default.
- W2004902484 creator A5028308964 @default.
- W2004902484 creator A5050684879 @default.
- W2004902484 creator A5071856790 @default.
- W2004902484 creator A5072894416 @default.
- W2004902484 date "1997-10-01" @default.
- W2004902484 modified "2023-10-06" @default.
- W2004902484 title "Hepatic Nuclear Factor 3 and High Mobility Group I/Y Proteins Bind the Insulin Response Element of the Insulin-Like Growth Factor-Binding Protein-1 Promoter*" @default.
- W2004902484 cites W1495386527 @default.
- W2004902484 cites W1504478980 @default.
- W2004902484 cites W1513296940 @default.
- W2004902484 cites W1521994227 @default.
- W2004902484 cites W1548068969 @default.
- W2004902484 cites W1558516755 @default.
- W2004902484 cites W1563700418 @default.
- W2004902484 cites W1570696801 @default.
- W2004902484 cites W1578799040 @default.
- W2004902484 cites W1631475273 @default.
- W2004902484 cites W1851046941 @default.
- W2004902484 cites W1944789111 @default.
- W2004902484 cites W1964064482 @default.
- W2004902484 cites W1964787551 @default.
- W2004902484 cites W1971334343 @default.
- W2004902484 cites W1973912514 @default.
- W2004902484 cites W1981067651 @default.
- W2004902484 cites W1982099849 @default.
- W2004902484 cites W1984700086 @default.
- W2004902484 cites W1986457555 @default.
- W2004902484 cites W1990283480 @default.
- W2004902484 cites W1991917303 @default.
- W2004902484 cites W1998625801 @default.
- W2004902484 cites W2001492668 @default.
- W2004902484 cites W2005144583 @default.
- W2004902484 cites W2005270847 @default.
- W2004902484 cites W2007473965 @default.
- W2004902484 cites W2011861484 @default.
- W2004902484 cites W2023100036 @default.
- W2004902484 cites W2032020317 @default.
- W2004902484 cites W2035913301 @default.
- W2004902484 cites W2047203795 @default.
- W2004902484 cites W2047701474 @default.
- W2004902484 cites W2051907392 @default.
- W2004902484 cites W2059589608 @default.
- W2004902484 cites W2059911808 @default.
- W2004902484 cites W2060017591 @default.
- W2004902484 cites W2088514626 @default.
- W2004902484 cites W2088573835 @default.
- W2004902484 cites W2097794242 @default.
- W2004902484 cites W2101958722 @default.
- W2004902484 cites W2107749241 @default.
- W2004902484 cites W2114623415 @default.
- W2004902484 cites W2129972061 @default.
- W2004902484 cites W2144206181 @default.
- W2004902484 cites W2158716547 @default.
- W2004902484 cites W4249627443 @default.
- W2004902484 doi "https://doi.org/10.1210/endo.138.10.5268" @default.
- W2004902484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9322942" @default.
- W2004902484 hasPublicationYear "1997" @default.
- W2004902484 type Work @default.
- W2004902484 sameAs 2004902484 @default.
- W2004902484 citedByCount "35" @default.
- W2004902484 countsByYear W20049024842012 @default.
- W2004902484 countsByYear W20049024842016 @default.
- W2004902484 countsByYear W20049024842021 @default.
- W2004902484 countsByYear W20049024842022 @default.
- W2004902484 crossrefType "journal-article" @default.
- W2004902484 hasAuthorship W2004902484A5007435264 @default.
- W2004902484 hasAuthorship W2004902484A5011062127 @default.
- W2004902484 hasAuthorship W2004902484A5028308964 @default.
- W2004902484 hasAuthorship W2004902484A5050684879 @default.
- W2004902484 hasAuthorship W2004902484A5071856790 @default.
- W2004902484 hasAuthorship W2004902484A5072894416 @default.
- W2004902484 hasBestOaLocation W20049024841 @default.
- W2004902484 hasConcept C104317684 @default.
- W2004902484 hasConcept C107824862 @default.
- W2004902484 hasConcept C112446052 @default.
- W2004902484 hasConcept C126322002 @default.
- W2004902484 hasConcept C134018914 @default.
- W2004902484 hasConcept C143065580 @default.
- W2004902484 hasConcept C153911025 @default.
- W2004902484 hasConcept C2777391703 @default.
- W2004902484 hasConcept C2779306644 @default.
- W2004902484 hasConcept C553089730 @default.
- W2004902484 hasConcept C55493867 @default.
- W2004902484 hasConcept C71924100 @default.
- W2004902484 hasConcept C82183700 @default.
- W2004902484 hasConcept C86339819 @default.
- W2004902484 hasConcept C86803240 @default.
- W2004902484 hasConcept C94966510 @default.
- W2004902484 hasConceptScore W2004902484C104317684 @default.
- W2004902484 hasConceptScore W2004902484C107824862 @default.
- W2004902484 hasConceptScore W2004902484C112446052 @default.
- W2004902484 hasConceptScore W2004902484C126322002 @default.
- W2004902484 hasConceptScore W2004902484C134018914 @default.
- W2004902484 hasConceptScore W2004902484C143065580 @default.