FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004906966> ?p ?o ?g. }

• W2004906966 endingPage "711" @default.
• W2004906966 startingPage "704" @default.
• W2004906966 abstract "In order to optimize and modulate bone formation it is essential to understand the expression patterns of key bone-specific growth factors, as osteoprogenitor cells undergo the processes of proliferation, differentiation and maturation. This study reports the sequential expression of bone-related growth and transcription factors when bone marrow-derived osteoprogenitor cells from C57BL mice were cultured on allograft bone discs. Mineralization and osteocalcin protein levels were used to track osteogenic differentiation and maturation. Bone-related growth factors, such as Bmp-2, Bmp-7, Ctnnb-1, Fgf-2, Igf-1, Vegf-a and Tgf-β1, and transcription factors, such as Runx-2 and osteocalcin, were examined by enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR). Total density of mineralized bone was significantly increased 7.6 ± 0.7% in allografts cultured with cells, compared with a 0.5 ± 2.0% increase in the controls without cells (p < 0.01). Osteocalcin protein levels peaked at day 4. Protein expression showed peaks of BMP-2 and TGF-β1 on day 2, with VEGF peaking on day 8, and IGF-1 decreasing on day 2. mRNA for Pdgf-a peaked on day 2; Bmp-2 on days 4 and 16; Ctnnb-1 on days 8 and 20; Vegf-a, Fgf-2, Runx-2 and Igf-1 on day 12; Tgf-β1 on day 16; and Pdgf-b on day 20. Osteogenic growth factors correlated with Runx-2 and Ctnnb-1, whereas a predominant vascular growth factor, Vegf-a, did not follow this pattern. Specific bone-related genes and proteins were expressed in a time-dependent manner when osteoprogenitor cells were cultured on cortico-cancellous bone discs in vitro. Copyright © 2010 John Wiley & Sons, Ltd." @default.
• W2004906966 created "2016-06-24" @default.
• W2004906966 creator A5011354286 @default.
• W2004906966 creator A5025299067 @default.
• W2004906966 creator A5025583043 @default.
• W2004906966 creator A5054126873 @default.
• W2004906966 creator A5066854533 @default.
• W2004906966 creator A5079599650 @default.
• W2004906966 date "2010-12-30" @default.
• W2004906966 modified "2023-09-27" @default.
• W2004906966 title "Molecular profile of osteoprogenitor cells seeded on allograft bone" @default.
• W2004906966 cites W122755776 @default.
• W2004906966 cites W1965830920 @default.
• W2004906966 cites W1967125513 @default.
• W2004906966 cites W1968590981 @default.
• W2004906966 cites W1968822620 @default.
• W2004906966 cites W1968837865 @default.
• W2004906966 cites W1969143454 @default.
• W2004906966 cites W1981274680 @default.
• W2004906966 cites W1984743383 @default.
• W2004906966 cites W2001552323 @default.
• W2004906966 cites W2003239533 @default.
• W2004906966 cites W2007617795 @default.
• W2004906966 cites W2014659613 @default.
• W2004906966 cites W2014756661 @default.
• W2004906966 cites W2018940887 @default.
• W2004906966 cites W2027464230 @default.
• W2004906966 cites W2030696265 @default.
• W2004906966 cites W2030913739 @default.
• W2004906966 cites W2033436710 @default.
• W2004906966 cites W2036352044 @default.
• W2004906966 cites W2036586548 @default.
• W2004906966 cites W2046096315 @default.
• W2004906966 cites W2069880766 @default.
• W2004906966 cites W2070384418 @default.
• W2004906966 cites W2071333416 @default.
• W2004906966 cites W2072905377 @default.
• W2004906966 cites W2081451346 @default.
• W2004906966 cites W2084847794 @default.
• W2004906966 cites W2085062063 @default.
• W2004906966 cites W2090918525 @default.
• W2004906966 cites W2092630549 @default.
• W2004906966 cites W2109623522 @default.
• W2004906966 cites W2117258058 @default.
• W2004906966 cites W2117757706 @default.
• W2004906966 cites W2118701732 @default.
• W2004906966 cites W2119491066 @default.
• W2004906966 cites W2124554277 @default.
• W2004906966 cites W2135374683 @default.
• W2004906966 cites W2137854259 @default.
• W2004906966 cites W2153454551 @default.
• W2004906966 cites W2161845595 @default.
• W2004906966 cites W2166650033 @default.
• W2004906966 cites W2322659163 @default.
• W2004906966 cites W2340804754 @default.
• W2004906966 cites W4236411505 @default.
• W2004906966 cites W4256046558 @default.
• W2004906966 doi "https://doi.org/10.1002/term.367" @default.
• W2004906966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21953868" @default.
• W2004906966 hasPublicationYear "2010" @default.
• W2004906966 type Work @default.
• W2004906966 sameAs 2004906966 @default.
• W2004906966 citedByCount "5" @default.
• W2004906966 countsByYear W20049069662013 @default.
• W2004906966 countsByYear W20049069662014 @default.
• W2004906966 countsByYear W20049069662015 @default.
• W2004906966 countsByYear W20049069662016 @default.
• W2004906966 crossrefType "journal-article" @default.
• W2004906966 hasAuthorship W2004906966A5011354286 @default.
• W2004906966 hasAuthorship W2004906966A5025299067 @default.
• W2004906966 hasAuthorship W2004906966A5025583043 @default.
• W2004906966 hasAuthorship W2004906966A5054126873 @default.
• W2004906966 hasAuthorship W2004906966A5066854533 @default.
• W2004906966 hasAuthorship W2004906966A5079599650 @default.
• W2004906966 hasBestOaLocation W20049069661 @default.
• W2004906966 hasConcept C104317684 @default.
• W2004906966 hasConcept C118131993 @default.
• W2004906966 hasConcept C125349252 @default.
• W2004906966 hasConcept C126322002 @default.
• W2004906966 hasConcept C131075544 @default.
• W2004906966 hasConcept C134018914 @default.
• W2004906966 hasConcept C153911025 @default.
• W2004906966 hasConcept C160160445 @default.
• W2004906966 hasConcept C16685009 @default.
• W2004906966 hasConcept C167734588 @default.
• W2004906966 hasConcept C170493617 @default.
• W2004906966 hasConcept C181199279 @default.
• W2004906966 hasConcept C185592680 @default.
• W2004906966 hasConcept C202751555 @default.
• W2004906966 hasConcept C203014093 @default.
• W2004906966 hasConcept C2775960820 @default.
• W2004906966 hasConcept C2777025900 @default.
• W2004906966 hasConcept C2778260815 @default.
• W2004906966 hasConcept C2780007613 @default.
• W2004906966 hasConcept C30352789 @default.
• W2004906966 hasConcept C31507581 @default.
• W2004906966 hasConcept C55493867 @default.
• W2004906966 hasConcept C71924100 @default.

• next