Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004906982> ?p ?o ?g. }
- W2004906982 endingPage "391" @default.
- W2004906982 startingPage "382" @default.
- W2004906982 abstract "Chronic cerebral hypoperfusion causes white-matter lesions (WMLs) with oxidative stress and cognitive impairment. However, the biologic mechanisms that regulate axonal plasticity under chronic cerebral hypoperfusion have not been fully investigated. Here, we investigated whether L-carnitine, an antioxidant agent, enhances axonal plasticity and oligodendrocyte expression, and explored the signaling pathways that mediate axonal plasticity in a rat chronic hypoperfusion model. Adult male Wistar rats subjected to ligation of the bilateral common carotid arteries (LBCCA) were treated with or without L-carnitine. L-carnitine-treated rats exhibited significantly reduced escape latency in the Morris water maze task at 28 days after chronic hypoperfusion. Western blot analysis indicated that L-carnitine increased levels of phosphorylated high-molecular weight neurofilament (pNFH), concurrent with a reduction in phosphorylated phosphatase tensin homolog deleted on chromosome 10 (PTEN), and increased phosphorylated Akt and mammalian target of rapamycin (mTOR) at 28 days after chronic hypoperfusion. L-carnitine reduced lipid peroxidation and oxidative DNA damage, and enhanced oligodendrocyte marker expression and myelin sheath thickness after chronic hypoperfusion. L-carnitine regulates the PTEN/Akt/mTOR signaling pathway, and enhances axonal plasticity while concurrently ameliorating oxidative stress and increasing oligodendrocyte myelination of axons, thereby improving WMLs and cognitive impairment in a rat chronic hypoperfusion model." @default.
- W2004906982 created "2016-06-24" @default.
- W2004906982 creator A5014705038 @default.
- W2004906982 creator A5016589120 @default.
- W2004906982 creator A5029738963 @default.
- W2004906982 creator A5037688368 @default.
- W2004906982 creator A5041604185 @default.
- W2004906982 creator A5053046195 @default.
- W2004906982 creator A5058983573 @default.
- W2004906982 creator A5077116570 @default.
- W2004906982 creator A5084716950 @default.
- W2004906982 date "2015-03-01" @default.
- W2004906982 modified "2023-09-30" @default.
- W2004906982 title "L-Carnitine Enhances Axonal Plasticity and Improves White-Matter Lesions after Chronic Hypoperfusion in Rat Brain" @default.
- W2004906982 cites W1966720057 @default.
- W2004906982 cites W1968109963 @default.
- W2004906982 cites W1969814448 @default.
- W2004906982 cites W1975029375 @default.
- W2004906982 cites W1975202788 @default.
- W2004906982 cites W1975749842 @default.
- W2004906982 cites W1976984383 @default.
- W2004906982 cites W1979885485 @default.
- W2004906982 cites W1981596049 @default.
- W2004906982 cites W1982647438 @default.
- W2004906982 cites W1987115729 @default.
- W2004906982 cites W1995986656 @default.
- W2004906982 cites W1997357659 @default.
- W2004906982 cites W2015224723 @default.
- W2004906982 cites W2034541898 @default.
- W2004906982 cites W2037623380 @default.
- W2004906982 cites W2060425858 @default.
- W2004906982 cites W2065213941 @default.
- W2004906982 cites W2075798709 @default.
- W2004906982 cites W2076422489 @default.
- W2004906982 cites W2077440654 @default.
- W2004906982 cites W2084080552 @default.
- W2004906982 cites W2086053019 @default.
- W2004906982 cites W2086605814 @default.
- W2004906982 cites W2094215712 @default.
- W2004906982 cites W2097011035 @default.
- W2004906982 cites W2104855192 @default.
- W2004906982 cites W2111692402 @default.
- W2004906982 cites W2120209337 @default.
- W2004906982 cites W2122738708 @default.
- W2004906982 cites W2124009251 @default.
- W2004906982 cites W2127202058 @default.
- W2004906982 cites W2145252529 @default.
- W2004906982 cites W2152165298 @default.
- W2004906982 cites W2166219187 @default.
- W2004906982 cites W2169374397 @default.
- W2004906982 cites W2170864733 @default.
- W2004906982 cites W3017311309 @default.
- W2004906982 cites W3099447526 @default.
- W2004906982 doi "https://doi.org/10.1038/jcbfm.2014.210" @default.
- W2004906982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4348379" @default.
- W2004906982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25465043" @default.
- W2004906982 hasPublicationYear "2015" @default.
- W2004906982 type Work @default.
- W2004906982 sameAs 2004906982 @default.
- W2004906982 citedByCount "55" @default.
- W2004906982 countsByYear W20049069822015 @default.
- W2004906982 countsByYear W20049069822016 @default.
- W2004906982 countsByYear W20049069822017 @default.
- W2004906982 countsByYear W20049069822018 @default.
- W2004906982 countsByYear W20049069822019 @default.
- W2004906982 countsByYear W20049069822020 @default.
- W2004906982 countsByYear W20049069822021 @default.
- W2004906982 countsByYear W20049069822022 @default.
- W2004906982 countsByYear W20049069822023 @default.
- W2004906982 crossrefType "journal-article" @default.
- W2004906982 hasAuthorship W2004906982A5014705038 @default.
- W2004906982 hasAuthorship W2004906982A5016589120 @default.
- W2004906982 hasAuthorship W2004906982A5029738963 @default.
- W2004906982 hasAuthorship W2004906982A5037688368 @default.
- W2004906982 hasAuthorship W2004906982A5041604185 @default.
- W2004906982 hasAuthorship W2004906982A5053046195 @default.
- W2004906982 hasAuthorship W2004906982A5058983573 @default.
- W2004906982 hasAuthorship W2004906982A5077116570 @default.
- W2004906982 hasAuthorship W2004906982A5084716950 @default.
- W2004906982 hasBestOaLocation W20049069821 @default.
- W2004906982 hasConcept C126322002 @default.
- W2004906982 hasConcept C126838900 @default.
- W2004906982 hasConcept C134018914 @default.
- W2004906982 hasConcept C142724271 @default.
- W2004906982 hasConcept C143409427 @default.
- W2004906982 hasConcept C169760540 @default.
- W2004906982 hasConcept C2776151105 @default.
- W2004906982 hasConcept C2776985911 @default.
- W2004906982 hasConcept C2778609137 @default.
- W2004906982 hasConcept C2781161787 @default.
- W2004906982 hasConcept C2781192897 @default.
- W2004906982 hasConcept C44752575 @default.
- W2004906982 hasConcept C529278444 @default.
- W2004906982 hasConcept C62478195 @default.
- W2004906982 hasConcept C71924100 @default.
- W2004906982 hasConcept C86554907 @default.
- W2004906982 hasConcept C86803240 @default.
- W2004906982 hasConcept C95444343 @default.