FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004906992> ?p ?o ?g. }

• W2004906992 endingPage "155" @default.
• W2004906992 startingPage "147" @default.
• W2004906992 abstract "Glucocorticoid (GC) plays a key role in controlling numerous cellular processes during embryogenesis and fetal development. The actions of glucocorticoids are mediated by interaction with their receptors. We previously reported that hippocampal neurons from embryonic day 18 (E18) rats showed silence of glucocorticoid receptor (GR) expression when cultured in serum-free condition. In this study, using western blot, immunofluorescence staining and real-time RT-PCR, we found that while this silence occurred in hippocampal neurons isolated from E16 and E18 rats, it did not happen in those from E20 and neonatal (P0) rats. And when cultured under serum-containing condition, none of them showed GR silence anymore. Corticosterone could not rescue the expression of GR in E16 and E18 neurons in serum-free condition, whereas adding of serum could induce the re-expression of the silenced GR. The absence of GR silence in P0 neurons was not due to the perturbation during parturition. Moreover, the unique expression profile of GR in protein and mRNA level was well reflected in the changes of GR function. These results suggested that under in vitro condition, serum was critical for the maintaining of GR expression in hippocampal neurons of early embryonic stages but less important in later developmental stages. Thus, our data implied that at different developmental stages, the expression of GR in hippocampal neurons might have different susceptibilities to environment changes and there might be a critical time window for the switching of such characteristics during development." @default.
• W2004906992 created "2016-06-24" @default.
• W2004906992 creator A5054687359 @default.
• W2004906992 creator A5074825288 @default.
• W2004906992 date "2008-07-01" @default.
• W2004906992 modified "2023-10-17" @default.
• W2004906992 title "Culture condition and embryonic stage dependent silence of glucocorticoid receptor expression in hippocampal neurons" @default.
• W2004906992 cites W1515307249 @default.
• W2004906992 cites W1867703876 @default.
• W2004906992 cites W1972170226 @default.
• W2004906992 cites W1995671210 @default.
• W2004906992 cites W2012405753 @default.
• W2004906992 cites W2020444746 @default.
• W2004906992 cites W2027911783 @default.
• W2004906992 cites W2038373034 @default.
• W2004906992 cites W2045869878 @default.
• W2004906992 cites W2049661270 @default.
• W2004906992 cites W2056408203 @default.
• W2004906992 cites W2060644077 @default.
• W2004906992 cites W2074802748 @default.
• W2004906992 cites W2076969034 @default.
• W2004906992 cites W2089081538 @default.
• W2004906992 cites W2094502922 @default.
• W2004906992 cites W2111586796 @default.
• W2004906992 cites W2114672383 @default.
• W2004906992 cites W2115474548 @default.
• W2004906992 cites W2121411996 @default.
• W2004906992 cites W2123543640 @default.
• W2004906992 cites W2133527597 @default.
• W2004906992 cites W2135160692 @default.
• W2004906992 cites W2162562731 @default.
• W2004906992 cites W2165802543 @default.
• W2004906992 cites W2171461865 @default.
• W2004906992 cites W2173254454 @default.
• W2004906992 cites W4237348831 @default.
• W2004906992 cites W4319292986 @default.
• W2004906992 doi "https://doi.org/10.1016/j.jsbmb.2008.03.036" @default.
• W2004906992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18625317" @default.
• W2004906992 hasPublicationYear "2008" @default.
• W2004906992 type Work @default.
• W2004906992 sameAs 2004906992 @default.
• W2004906992 citedByCount "7" @default.
• W2004906992 countsByYear W20049069922013 @default.
• W2004906992 countsByYear W20049069922017 @default.
• W2004906992 countsByYear W20049069922019 @default.
• W2004906992 countsByYear W20049069922022 @default.
• W2004906992 crossrefType "journal-article" @default.
• W2004906992 hasAuthorship W2004906992A5054687359 @default.
• W2004906992 hasAuthorship W2004906992A5074825288 @default.
• W2004906992 hasConcept C104317684 @default.
• W2004906992 hasConcept C126322002 @default.
• W2004906992 hasConcept C134018914 @default.
• W2004906992 hasConcept C145103041 @default.
• W2004906992 hasConcept C148762608 @default.
• W2004906992 hasConcept C169760540 @default.
• W2004906992 hasConcept C170493617 @default.
• W2004906992 hasConcept C172680121 @default.
• W2004906992 hasConcept C196843134 @default.
• W2004906992 hasConcept C2776415932 @default.
• W2004906992 hasConcept C2778794669 @default.
• W2004906992 hasConcept C2779234561 @default.
• W2004906992 hasConcept C2780352252 @default.
• W2004906992 hasConcept C2780841215 @default.
• W2004906992 hasConcept C54355233 @default.
• W2004906992 hasConcept C59493245 @default.
• W2004906992 hasConcept C71315377 @default.
• W2004906992 hasConcept C71924100 @default.
• W2004906992 hasConcept C86803240 @default.
• W2004906992 hasConcept C87073359 @default.
• W2004906992 hasConcept C95444343 @default.
• W2004906992 hasConceptScore W2004906992C104317684 @default.
• W2004906992 hasConceptScore W2004906992C126322002 @default.
• W2004906992 hasConceptScore W2004906992C134018914 @default.
• W2004906992 hasConceptScore W2004906992C145103041 @default.
• W2004906992 hasConceptScore W2004906992C148762608 @default.
• W2004906992 hasConceptScore W2004906992C169760540 @default.
• W2004906992 hasConceptScore W2004906992C170493617 @default.
• W2004906992 hasConceptScore W2004906992C172680121 @default.
• W2004906992 hasConceptScore W2004906992C196843134 @default.
• W2004906992 hasConceptScore W2004906992C2776415932 @default.
• W2004906992 hasConceptScore W2004906992C2778794669 @default.
• W2004906992 hasConceptScore W2004906992C2779234561 @default.
• W2004906992 hasConceptScore W2004906992C2780352252 @default.
• W2004906992 hasConceptScore W2004906992C2780841215 @default.
• W2004906992 hasConceptScore W2004906992C54355233 @default.
• W2004906992 hasConceptScore W2004906992C59493245 @default.
• W2004906992 hasConceptScore W2004906992C71315377 @default.
• W2004906992 hasConceptScore W2004906992C71924100 @default.
• W2004906992 hasConceptScore W2004906992C86803240 @default.
• W2004906992 hasConceptScore W2004906992C87073359 @default.
• W2004906992 hasConceptScore W2004906992C95444343 @default.
• W2004906992 hasIssue "1-2" @default.
• W2004906992 hasLocation W20049069921 @default.
• W2004906992 hasLocation W20049069922 @default.
• W2004906992 hasOpenAccess W2004906992 @default.
• W2004906992 hasPrimaryLocation W20049069921 @default.
• W2004906992 hasRelatedWork W1756428141 @default.
• W2004906992 hasRelatedWork W2005344166 @default.

• next