FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004908650> ?p ?o ?g. }

• W2004908650 endingPage "2076" @default.
• W2004908650 startingPage "2071" @default.
• W2004908650 abstract "An experimental strategy to facilitate correction of single-base mutations of episomal targets in mammalian cells has been developed. The method utilizes a chimeric oligonucleotide composed of a contiguous stretch of RNA and DNA residues in a duplex conformation with double hairpin caps on the ends. The RNA/DNA sequence is designed to align with the sequence of the mutant locus and to contain the desired nucleotide change. Activity of the chimeric molecule in targeted correction was tested in a model system in which the aim was to correct a point mutation in the gene encoding the human liver/bone/kidney alkaline phosphatase. When the chimeric molecule was introduced into cells containing the mutant gene on an extrachromosomal plasmid, correction of the point mutation was accomplished with a frequency approaching 30%. These results extend the usefulness of the oligonucleotide-based gene targeting approaches by increasing specific targeting frequency. This strategy should enable the design of antiviral agents." @default.
• W2004908650 created "2016-06-24" @default.
• W2004908650 creator A5035008501 @default.
• W2004908650 creator A5063334368 @default.
• W2004908650 creator A5081138565 @default.
• W2004908650 date "1996-03-05" @default.
• W2004908650 modified "2023-09-27" @default.
• W2004908650 title "Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide." @default.
• W2004908650 cites W1491179232 @default.
• W2004908650 cites W1564730852 @default.
• W2004908650 cites W1582040861 @default.
• W2004908650 cites W169569400 @default.
• W2004908650 cites W1748230033 @default.
• W2004908650 cites W1973772928 @default.
• W2004908650 cites W1981089692 @default.
• W2004908650 cites W1983237714 @default.
• W2004908650 cites W1983385891 @default.
• W2004908650 cites W1987659048 @default.
• W2004908650 cites W1993834457 @default.
• W2004908650 cites W2004059420 @default.
• W2004908650 cites W2024675966 @default.
• W2004908650 cites W2037685690 @default.
• W2004908650 cites W2048789659 @default.
• W2004908650 cites W2049782765 @default.
• W2004908650 cites W2057214003 @default.
• W2004908650 cites W2059901912 @default.
• W2004908650 cites W2072370387 @default.
• W2004908650 cites W2078904081 @default.
• W2004908650 cites W2092806325 @default.
• W2004908650 cites W2105756213 @default.
• W2004908650 cites W2105988074 @default.
• W2004908650 cites W2123196835 @default.
• W2004908650 cites W2129242502 @default.
• W2004908650 cites W2129399211 @default.
• W2004908650 cites W2141509764 @default.
• W2004908650 cites W2154181923 @default.
• W2004908650 cites W2162824445 @default.
• W2004908650 cites W2168169967 @default.
• W2004908650 cites W4256704256 @default.
• W2004908650 doi "https://doi.org/10.1073/pnas.93.5.2071" @default.
• W2004908650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39911" @default.
• W2004908650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8700887" @default.
• W2004908650 hasPublicationYear "1996" @default.
• W2004908650 type Work @default.
• W2004908650 sameAs 2004908650 @default.
• W2004908650 citedByCount "206" @default.
• W2004908650 countsByYear W20049086502012 @default.
• W2004908650 countsByYear W20049086502013 @default.
• W2004908650 countsByYear W20049086502014 @default.
• W2004908650 countsByYear W20049086502015 @default.
• W2004908650 countsByYear W20049086502016 @default.
• W2004908650 countsByYear W20049086502017 @default.
• W2004908650 countsByYear W20049086502018 @default.
• W2004908650 countsByYear W20049086502019 @default.
• W2004908650 countsByYear W20049086502020 @default.
• W2004908650 countsByYear W20049086502021 @default.
• W2004908650 countsByYear W20049086502022 @default.
• W2004908650 crossrefType "journal-article" @default.
• W2004908650 hasAuthorship W2004908650A5035008501 @default.
• W2004908650 hasAuthorship W2004908650A5063334368 @default.
• W2004908650 hasAuthorship W2004908650A5081138565 @default.
• W2004908650 hasBestOaLocation W20049086501 @default.
• W2004908650 hasConcept C104317684 @default.
• W2004908650 hasConcept C111829913 @default.
• W2004908650 hasConcept C129312508 @default.
• W2004908650 hasConcept C143065580 @default.
• W2004908650 hasConcept C150194340 @default.
• W2004908650 hasConcept C153911025 @default.
• W2004908650 hasConcept C176944494 @default.
• W2004908650 hasConcept C185581394 @default.
• W2004908650 hasConcept C22744801 @default.
• W2004908650 hasConcept C26260077 @default.
• W2004908650 hasConcept C54355233 @default.
• W2004908650 hasConcept C552990157 @default.
• W2004908650 hasConcept C67705224 @default.
• W2004908650 hasConcept C86803240 @default.
• W2004908650 hasConcept C89684784 @default.
• W2004908650 hasConceptScore W2004908650C104317684 @default.
• W2004908650 hasConceptScore W2004908650C111829913 @default.
• W2004908650 hasConceptScore W2004908650C129312508 @default.
• W2004908650 hasConceptScore W2004908650C143065580 @default.
• W2004908650 hasConceptScore W2004908650C150194340 @default.
• W2004908650 hasConceptScore W2004908650C153911025 @default.
• W2004908650 hasConceptScore W2004908650C176944494 @default.
• W2004908650 hasConceptScore W2004908650C185581394 @default.
• W2004908650 hasConceptScore W2004908650C22744801 @default.
• W2004908650 hasConceptScore W2004908650C26260077 @default.
• W2004908650 hasConceptScore W2004908650C54355233 @default.
• W2004908650 hasConceptScore W2004908650C552990157 @default.
• W2004908650 hasConceptScore W2004908650C67705224 @default.
• W2004908650 hasConceptScore W2004908650C86803240 @default.
• W2004908650 hasConceptScore W2004908650C89684784 @default.
• W2004908650 hasIssue "5" @default.
• W2004908650 hasLocation W20049086501 @default.
• W2004908650 hasLocation W20049086502 @default.
• W2004908650 hasLocation W20049086503 @default.
• W2004908650 hasLocation W20049086504 @default.
• W2004908650 hasOpenAccess W2004908650 @default.

• next