FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004910395> ?p ?o ?g. }

• W2004910395 endingPage "15511" @default.
• W2004910395 startingPage "15502" @default.
• W2004910395 abstract "Coenzyme B(12)-dependent acyl-CoA mutases are radical enzymes catalyzing reversible carbon skeleton rearrangements in carboxylic acids. Here, we describe 2-hydroxyisobutyryl-CoA mutase (HCM) found in the bacterium Aquincola tertiaricarbonis as a novel member of the mutase family. HCM specifically catalyzes the interconversion of 2-hydroxyisobutyryl- and (S)-3-hydroxybutyryl-CoA. Like isobutyryl-CoA mutase, HCM consists of a large substrate- and a small B(12)-binding subunit, HcmA and HcmB, respectively. However, it is thus far the only acyl-CoA mutase showing substrate specificity for hydroxylated carboxylic acids. Complete loss of 2-hydroxyisobutyric acid degradation capacity in hcmA and hcmB knock-out mutants established the central role of HCM in A. tertiaricarbonis for degrading substrates bearing a tert-butyl moiety, such as the fuel oxygenate methyl tert-butyl ether (MTBE) and its metabolites. Sequence analysis revealed several HCM-like enzymes in other bacterial strains not related to MTBE degradation, indicating that HCM may also be involved in other pathways. In all strains, hcmA and hcmB are associated with genes encoding for a putative acyl-CoA synthetase and a MeaB-like chaperone. Activity and substrate specificity of wild-type enzyme and active site mutants HcmA I90V, I90F, and I90Y clearly demonstrated that HCM belongs to a new subfamily of B(12)-dependent acyl-CoA mutases." @default.
• W2004910395 created "2016-06-24" @default.
• W2004910395 creator A5000487398 @default.
• W2004910395 creator A5012520069 @default.
• W2004910395 creator A5026087931 @default.
• W2004910395 creator A5032669248 @default.
• W2004910395 creator A5044101820 @default.
• W2004910395 creator A5057127336 @default.
• W2004910395 creator A5075708345 @default.
• W2004910395 creator A5083519174 @default.
• W2004910395 creator A5085935838 @default.
• W2004910395 date "2012-05-01" @default.
• W2004910395 modified "2023-10-17" @default.
• W2004910395 title "Bacterial Acyl-CoA Mutase Specifically Catalyzes Coenzyme B12-dependent Isomerization of 2-Hydroxyisobutyryl-CoA and (S)-3-Hydroxybutyryl-CoA" @default.
• W2004910395 cites W1483463342 @default.
• W2004910395 cites W1585123031 @default.
• W2004910395 cites W1934685598 @default.
• W2004910395 cites W1941725653 @default.
• W2004910395 cites W1967764646 @default.
• W2004910395 cites W1968710052 @default.
• W2004910395 cites W1969469578 @default.
• W2004910395 cites W1970792897 @default.
• W2004910395 cites W1979841245 @default.
• W2004910395 cites W1995946683 @default.
• W2004910395 cites W2018478469 @default.
• W2004910395 cites W2027758477 @default.
• W2004910395 cites W2032571964 @default.
• W2004910395 cites W2035839201 @default.
• W2004910395 cites W2042019520 @default.
• W2004910395 cites W2066228976 @default.
• W2004910395 cites W2068121636 @default.
• W2004910395 cites W2084851321 @default.
• W2004910395 cites W2093878978 @default.
• W2004910395 cites W2101977455 @default.
• W2004910395 cites W2104859037 @default.
• W2004910395 cites W2107979780 @default.
• W2004910395 cites W2116191391 @default.
• W2004910395 cites W2128424256 @default.
• W2004910395 cites W2134884668 @default.
• W2004910395 cites W2148937292 @default.
• W2004910395 cites W2154611588 @default.
• W2004910395 cites W2156579005 @default.
• W2004910395 cites W2158714788 @default.
• W2004910395 cites W2161172925 @default.
• W2004910395 cites W2320934986 @default.
• W2004910395 doi "https://doi.org/10.1074/jbc.m111.314690" @default.
• W2004910395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3346121" @default.
• W2004910395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22433853" @default.
• W2004910395 hasPublicationYear "2012" @default.
• W2004910395 type Work @default.
• W2004910395 sameAs 2004910395 @default.
• W2004910395 citedByCount "33" @default.
• W2004910395 countsByYear W20049103952012 @default.
• W2004910395 countsByYear W20049103952013 @default.
• W2004910395 countsByYear W20049103952014 @default.
• W2004910395 countsByYear W20049103952015 @default.
• W2004910395 countsByYear W20049103952016 @default.
• W2004910395 countsByYear W20049103952017 @default.
• W2004910395 countsByYear W20049103952018 @default.
• W2004910395 countsByYear W20049103952019 @default.
• W2004910395 countsByYear W20049103952020 @default.
• W2004910395 countsByYear W20049103952021 @default.
• W2004910395 countsByYear W20049103952022 @default.
• W2004910395 countsByYear W20049103952023 @default.
• W2004910395 crossrefType "journal-article" @default.
• W2004910395 hasAuthorship W2004910395A5000487398 @default.
• W2004910395 hasAuthorship W2004910395A5012520069 @default.
• W2004910395 hasAuthorship W2004910395A5026087931 @default.
• W2004910395 hasAuthorship W2004910395A5032669248 @default.
• W2004910395 hasAuthorship W2004910395A5044101820 @default.
• W2004910395 hasAuthorship W2004910395A5057127336 @default.
• W2004910395 hasAuthorship W2004910395A5075708345 @default.
• W2004910395 hasAuthorship W2004910395A5083519174 @default.
• W2004910395 hasAuthorship W2004910395A5085935838 @default.
• W2004910395 hasBestOaLocation W20049103951 @default.
• W2004910395 hasConcept C104317684 @default.
• W2004910395 hasConcept C134651460 @default.
• W2004910395 hasConcept C143065580 @default.
• W2004910395 hasConcept C181199279 @default.
• W2004910395 hasConcept C185592680 @default.
• W2004910395 hasConcept C197957613 @default.
• W2004910395 hasConcept C2777552656 @default.
• W2004910395 hasConcept C2779123261 @default.
• W2004910395 hasConcept C2779685201 @default.
• W2004910395 hasConcept C55493867 @default.
• W2004910395 hasConcept C71240020 @default.
• W2004910395 hasConcept C86803240 @default.
• W2004910395 hasConceptScore W2004910395C104317684 @default.
• W2004910395 hasConceptScore W2004910395C134651460 @default.
• W2004910395 hasConceptScore W2004910395C143065580 @default.
• W2004910395 hasConceptScore W2004910395C181199279 @default.
• W2004910395 hasConceptScore W2004910395C185592680 @default.
• W2004910395 hasConceptScore W2004910395C197957613 @default.
• W2004910395 hasConceptScore W2004910395C2777552656 @default.
• W2004910395 hasConceptScore W2004910395C2779123261 @default.
• W2004910395 hasConceptScore W2004910395C2779685201 @default.
• W2004910395 hasConceptScore W2004910395C55493867 @default.
• W2004910395 hasConceptScore W2004910395C71240020 @default.

• next