Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004917272> ?p ?o ?g. }
- W2004917272 endingPage "299" @default.
- W2004917272 startingPage "290" @default.
- W2004917272 abstract "In major depression, the neural mechanisms underlying suicide related thoughts and behaviors as well as the expression of other depressive symptoms are incompletely characterized. Evidence indicates that both the striatum and cortical midline structures (CMS) may be involved with both suicide and emotional dysregulation in unipolar illness. The aim of this study was to identify striatal–CMS circuits associated with current depression severity and suicidal ideation (SI) as well as a history of self-harm. Twenty-two male subjects with recurrent unipolar depression were studied using functional MRI. All subjects were unmedicated and without current psychiatric comorbidity. Correlational analyses were used to determine whether striatal–CMS functional connectivity was associated with any of the three clinical variables. A network involving the bilateral striatum and anterior CMS was found to be associated with depressive symptom severity. Current SI was associated with a similar but less extensive circuit in the left hemisphere. A distinct striatal motor/sensory network was associated with self-harm behaviors, but not current SI or depression severity. The striatal–anterior CMS circuit likely plays a significant role in the expression of depressive symptoms and SI. In contrast, a striatum–motor/sensory cortex network may be a trait marker of suicide-related behaviors. If replicated, this result might eventually lead to the development of a biomarker that would be useful for studies of pharmacologic and/or psychotherapeutic suicide prevention interventions." @default.
- W2004917272 created "2016-06-24" @default.
- W2004917272 creator A5028030680 @default.
- W2004917272 creator A5029421723 @default.
- W2004917272 creator A5039173419 @default.
- W2004917272 creator A5055806604 @default.
- W2004917272 creator A5055979780 @default.
- W2004917272 creator A5066675567 @default.
- W2004917272 creator A5089208598 @default.
- W2004917272 date "2012-03-01" @default.
- W2004917272 modified "2023-10-01" @default.
- W2004917272 title "Striatal and cortical midline circuits in major depression: Implications for suicide and symptom expression" @default.
- W2004917272 cites W1608229171 @default.
- W2004917272 cites W1660599875 @default.
- W2004917272 cites W1726806887 @default.
- W2004917272 cites W1929205930 @default.
- W2004917272 cites W1964476186 @default.
- W2004917272 cites W1966647036 @default.
- W2004917272 cites W1967254881 @default.
- W2004917272 cites W1967822215 @default.
- W2004917272 cites W1967880030 @default.
- W2004917272 cites W1969303073 @default.
- W2004917272 cites W1969672037 @default.
- W2004917272 cites W1970090972 @default.
- W2004917272 cites W1970213025 @default.
- W2004917272 cites W1970485322 @default.
- W2004917272 cites W1972339561 @default.
- W2004917272 cites W1973093449 @default.
- W2004917272 cites W1973576997 @default.
- W2004917272 cites W1974156059 @default.
- W2004917272 cites W1976460631 @default.
- W2004917272 cites W1980396263 @default.
- W2004917272 cites W1984166706 @default.
- W2004917272 cites W1988948862 @default.
- W2004917272 cites W1989248461 @default.
- W2004917272 cites W1991880588 @default.
- W2004917272 cites W1994181394 @default.
- W2004917272 cites W1997245512 @default.
- W2004917272 cites W1997625719 @default.
- W2004917272 cites W2002611894 @default.
- W2004917272 cites W2009140566 @default.
- W2004917272 cites W2013140360 @default.
- W2004917272 cites W2022730288 @default.
- W2004917272 cites W2028126838 @default.
- W2004917272 cites W2029087506 @default.
- W2004917272 cites W2029397722 @default.
- W2004917272 cites W2030007543 @default.
- W2004917272 cites W2030871689 @default.
- W2004917272 cites W2031308870 @default.
- W2004917272 cites W2031548929 @default.
- W2004917272 cites W2032378574 @default.
- W2004917272 cites W2032639509 @default.
- W2004917272 cites W2036916152 @default.
- W2004917272 cites W2039522025 @default.
- W2004917272 cites W2039708012 @default.
- W2004917272 cites W2042050620 @default.
- W2004917272 cites W2042580638 @default.
- W2004917272 cites W2042657364 @default.
- W2004917272 cites W2043887247 @default.
- W2004917272 cites W2044710410 @default.
- W2004917272 cites W2046993289 @default.
- W2004917272 cites W2048975802 @default.
- W2004917272 cites W2051499326 @default.
- W2004917272 cites W2054324239 @default.
- W2004917272 cites W2056081184 @default.
- W2004917272 cites W2058480468 @default.
- W2004917272 cites W2059217700 @default.
- W2004917272 cites W2060192006 @default.
- W2004917272 cites W2063672943 @default.
- W2004917272 cites W2064000597 @default.
- W2004917272 cites W2064297315 @default.
- W2004917272 cites W2067529879 @default.
- W2004917272 cites W2068087499 @default.
- W2004917272 cites W2070499954 @default.
- W2004917272 cites W2078363311 @default.
- W2004917272 cites W2079866440 @default.
- W2004917272 cites W2080527898 @default.
- W2004917272 cites W2083730492 @default.
- W2004917272 cites W2089871182 @default.
- W2004917272 cites W2089926222 @default.
- W2004917272 cites W2091858219 @default.
- W2004917272 cites W2093962936 @default.
- W2004917272 cites W2097194831 @default.
- W2004917272 cites W2098818989 @default.
- W2004917272 cites W2100036649 @default.
- W2004917272 cites W2107852270 @default.
- W2004917272 cites W2108735866 @default.
- W2004917272 cites W2110040374 @default.
- W2004917272 cites W2111726505 @default.
- W2004917272 cites W2115022263 @default.
- W2004917272 cites W2115323362 @default.
- W2004917272 cites W2117877144 @default.
- W2004917272 cites W2125439972 @default.
- W2004917272 cites W2127061615 @default.
- W2004917272 cites W2129965408 @default.
- W2004917272 cites W2131823335 @default.
- W2004917272 cites W2133817276 @default.
- W2004917272 cites W2135925788 @default.