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- W2004919635 abstract "The mTOR signaling network functions as a pivotal regulatory cascade during the development of the cerebral cortex. Aberrant hyperactivation of mTOR as a consequence of loss-of-function gene mutations encoding mTOR inhibitor proteins such as TSC1, TSC2, PTEN and STRADα has been recently linked to developmental cortical malformations associated with epilepsy and neurobehavioral disabilities. Investigation of mTOR signaling in these disorders provides for the first time exciting future avenues for assessment of biomarkers, patient stratification and prognostic measures as well as the opportunity for targeted therapy to regulate mTOR activity across all age groups. As we learn more about mTOR and its activity in the developing brain, many challenges will arise that must be overcome before widespread clinical therapeutics can be implemented." @default.
- W2004919635 created "2016-06-24" @default.
- W2004919635 creator A5039136394 @default.
- W2004919635 date "2011-12-01" @default.
- W2004919635 modified "2023-10-09" @default.
- W2004919635 title "mTOR: A pathogenic signaling pathway in developmental brain malformations" @default.
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- W2004919635 doi "https://doi.org/10.1016/j.molmed.2011.07.008" @default.
- W2004919635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21890410" @default.