Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004927126> ?p ?o ?g. }
- W2004927126 endingPage "67" @default.
- W2004927126 startingPage "61" @default.
- W2004927126 abstract "The stability ofatriopeptin III (APIII) encapsulated in poly (d,l-lactide-co-glycolide) (PLGA) microspheres has been investigated and compared to the stability of APIII alone. When the microspheres are shaken in Tris-buffered Ringer's (pH 7.4) at 40°C, the APIII inside of the microspheres is completely degraded in 5 days. Though APIII is stable in microspheres that are stored desiccated at −20°C, when the microspheres are stored in 95% relative humidity at 40°C there is 20% degradation of APIII in 8 days. Concentrated APIII, on the other hand, shows no degradation after 2 weeks at 40°C and dilute APIII in water shows no loss after 1 month at 40°C. In Tris-buffered Ringer's (pH 7.4) at 40°C, however, dilute APIII degrades with a half life of 8.7 days unshaken or 2.4 days when shaken. The pattern of degradation peaks seen during HPLC analysis of samples degraded in the presence of PLGA is different than that seen when APIII alone degrades in buffer solution. These experiments indicate that PLGA may not be an appropriate polymer for use with some peptides and proteins." @default.
- W2004927126 created "2016-06-24" @default.
- W2004927126 creator A5015851590 @default.
- W2004927126 creator A5021027378 @default.
- W2004927126 creator A5021697584 @default.
- W2004927126 creator A5036476297 @default.
- W2004927126 creator A5040353518 @default.
- W2004927126 creator A5055080525 @default.
- W2004927126 creator A5072494376 @default.
- W2004927126 date "1991-09-01" @default.
- W2004927126 modified "2023-10-16" @default.
- W2004927126 title "Stability of atriopeptin III in poly(d,l-lactide-co-glycolide) microspheres" @default.
- W2004927126 cites W1605314587 @default.
- W2004927126 cites W1894512109 @default.
- W2004927126 cites W1971303378 @default.
- W2004927126 cites W1973840814 @default.
- W2004927126 cites W1984675082 @default.
- W2004927126 cites W1985560960 @default.
- W2004927126 cites W1997427419 @default.
- W2004927126 cites W2002670246 @default.
- W2004927126 cites W2025626337 @default.
- W2004927126 cites W2025684292 @default.
- W2004927126 cites W2058206817 @default.
- W2004927126 cites W2095536362 @default.
- W2004927126 cites W2121521999 @default.
- W2004927126 cites W2146841362 @default.
- W2004927126 cites W2249320413 @default.
- W2004927126 cites W23296051 @default.
- W2004927126 cites W4252618647 @default.
- W2004927126 doi "https://doi.org/10.1016/0168-3659(91)90131-v" @default.
- W2004927126 hasPublicationYear "1991" @default.
- W2004927126 type Work @default.
- W2004927126 sameAs 2004927126 @default.
- W2004927126 citedByCount "59" @default.
- W2004927126 countsByYear W20049271262013 @default.
- W2004927126 countsByYear W20049271262016 @default.
- W2004927126 countsByYear W20049271262017 @default.
- W2004927126 countsByYear W20049271262018 @default.
- W2004927126 countsByYear W20049271262020 @default.
- W2004927126 crossrefType "journal-article" @default.
- W2004927126 hasAuthorship W2004927126A5015851590 @default.
- W2004927126 hasAuthorship W2004927126A5021027378 @default.
- W2004927126 hasAuthorship W2004927126A5021697584 @default.
- W2004927126 hasAuthorship W2004927126A5036476297 @default.
- W2004927126 hasAuthorship W2004927126A5040353518 @default.
- W2004927126 hasAuthorship W2004927126A5055080525 @default.
- W2004927126 hasAuthorship W2004927126A5072494376 @default.
- W2004927126 hasConcept C121332964 @default.
- W2004927126 hasConcept C127413603 @default.
- W2004927126 hasConcept C13965031 @default.
- W2004927126 hasConcept C145018004 @default.
- W2004927126 hasConcept C158960510 @default.
- W2004927126 hasConcept C15920480 @default.
- W2004927126 hasConcept C178790620 @default.
- W2004927126 hasConcept C185592680 @default.
- W2004927126 hasConcept C188027245 @default.
- W2004927126 hasConcept C189942447 @default.
- W2004927126 hasConcept C202751555 @default.
- W2004927126 hasConcept C2776743539 @default.
- W2004927126 hasConcept C2779679103 @default.
- W2004927126 hasConcept C2780165375 @default.
- W2004927126 hasConcept C2781014771 @default.
- W2004927126 hasConcept C41008148 @default.
- W2004927126 hasConcept C42360764 @default.
- W2004927126 hasConcept C43617362 @default.
- W2004927126 hasConcept C521977710 @default.
- W2004927126 hasConcept C55493867 @default.
- W2004927126 hasConcept C76155785 @default.
- W2004927126 hasConcept C97355855 @default.
- W2004927126 hasConceptScore W2004927126C121332964 @default.
- W2004927126 hasConceptScore W2004927126C127413603 @default.
- W2004927126 hasConceptScore W2004927126C13965031 @default.
- W2004927126 hasConceptScore W2004927126C145018004 @default.
- W2004927126 hasConceptScore W2004927126C158960510 @default.
- W2004927126 hasConceptScore W2004927126C15920480 @default.
- W2004927126 hasConceptScore W2004927126C178790620 @default.
- W2004927126 hasConceptScore W2004927126C185592680 @default.
- W2004927126 hasConceptScore W2004927126C188027245 @default.
- W2004927126 hasConceptScore W2004927126C189942447 @default.
- W2004927126 hasConceptScore W2004927126C202751555 @default.
- W2004927126 hasConceptScore W2004927126C2776743539 @default.
- W2004927126 hasConceptScore W2004927126C2779679103 @default.
- W2004927126 hasConceptScore W2004927126C2780165375 @default.
- W2004927126 hasConceptScore W2004927126C2781014771 @default.
- W2004927126 hasConceptScore W2004927126C41008148 @default.
- W2004927126 hasConceptScore W2004927126C42360764 @default.
- W2004927126 hasConceptScore W2004927126C43617362 @default.
- W2004927126 hasConceptScore W2004927126C521977710 @default.
- W2004927126 hasConceptScore W2004927126C55493867 @default.
- W2004927126 hasConceptScore W2004927126C76155785 @default.
- W2004927126 hasConceptScore W2004927126C97355855 @default.
- W2004927126 hasIssue "1" @default.
- W2004927126 hasLocation W20049271261 @default.
- W2004927126 hasOpenAccess W2004927126 @default.
- W2004927126 hasPrimaryLocation W20049271261 @default.
- W2004927126 hasRelatedWork W1978266997 @default.
- W2004927126 hasRelatedWork W1981567094 @default.
- W2004927126 hasRelatedWork W1985366275 @default.