FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004927896> ?p ?o ?g. }

• W2004927896 endingPage "602" @default.
• W2004927896 startingPage "593" @default.
• W2004927896 abstract "The stability constants of the 1:1 complexes formed in aqueous solution between Mg2+, Ca2+, Sr2+, Ba2+, Mn2+, Co2+, Ni2+, Zn2+, or Cd2+ (M2+) and methyl thiophosphate (MeOPS(2-)) or uridine 5'-O-thiomonophosphate (UMPS(2-)) (PS(2-)=MeOPS(2-) or UMPS(2-)) have been determined (potentiometric pH titrations; 25 degrees C; I = 0.1 M, NaNO(3)). Comparison of these results for M(PS) complexes with those known for the parent M(PO) phosphate species, where PO(2-)=CH(3)OPO(2-)(3) or UMP(2-) (uridine 5'-monophosphate), shows that the alkaline earth metal ions, as well as Mn2+, Co2+, and Ni2+ have a higher affinity for phosphate groups than for their thio analogues. However, based on the linear log K(M)(M(R-PO3)) versus pK(H)(H(R-PO3)) relationships (R-PO(2-)(3) simple phosphate monoester or phosphonate ligands with a non-interacting residue R) it becomes clear that the indicated observation is only the result of the lower basicity of the thiophosphate residue. In contrast, the thio complexes of Zn2+ and Cd2+ are more stable than their parent phosphate ones, and this despite the lower basicity of the PS(2-) ligands. This stability increase is identical for M(MeOPS) and M(UMPS) species and amounts to about 0.6 and 2.4 log units for Zn(PS) and Cd(PS), respectively. Since no other binding site is available in MeOPS(2-), this enhanced stability has to be attributed to the S atom. Indeed, from the mentioned stability differences it follows that Cd2+ in Cd(PS) is coordinated by more than 99% to the thiophosphate S atom; the same value holds for Pb(PS), which was studied earlier. The formation degree of the Sbonded isomer amounts to 76+/-6 % for Zn(PS) and is close to zero for the corresponding Mg2+, Ca2+, and Mn2+ species. It is further shown that Zn(MeOPS)(aq)(2+) releases a proton from a coordinated water molecule with pK(a) approximately 6.9; i.e., this deprotonation occurs at a lower pH value than that for the same reaction in Zn(aq)(2+). Since Mg2+, Ca2+, Mn2+, and Cd2+ have a relatively low tendency for hydroxo complex formation, it was possible, for these M2+, to also quantify the stability of the binuclear complexes, M(2)(UMPS-H)+, where one M2+ is thiophosphate-coordinated and the other is coordinated at (N3)(-) of the uracil residue. The impact of the results presented herein regarding M2+/nucleic acid interactions, including those of ribozymes (rescue experiments), is briefly discussed." @default.
• W2004927896 created "2016-06-24" @default.
• W2004927896 creator A5060495399 @default.
• W2004927896 creator A5069204119 @default.
• W2004927896 creator A5073423429 @default.
• W2004927896 date "2003-06-27" @default.
• W2004927896 modified "2023-10-17" @default.
• W2004927896 title "Complex Formation of Divalent Metal Ions with Uridine 5′-O-Thiomonophosphate or Methyl Thiophosphate: Comparison of Complex Stabilities with Those of the Parent Phosphate Ligands" @default.
• W2004927896 cites W139107379 @default.
• W2004927896 cites W1563100948 @default.
• W2004927896 cites W1963923989 @default.
• W2004927896 cites W1965753868 @default.
• W2004927896 cites W1966812135 @default.
• W2004927896 cites W1969995031 @default.
• W2004927896 cites W1971859519 @default.
• W2004927896 cites W1972746334 @default.
• W2004927896 cites W1974059877 @default.
• W2004927896 cites W1987511312 @default.
• W2004927896 cites W1993005258 @default.
• W2004927896 cites W1994204471 @default.
• W2004927896 cites W1999715074 @default.
• W2004927896 cites W2001679506 @default.
• W2004927896 cites W2001953599 @default.
• W2004927896 cites W2007151671 @default.
• W2004927896 cites W2007571603 @default.
• W2004927896 cites W2008595211 @default.
• W2004927896 cites W2008627952 @default.
• W2004927896 cites W2009436907 @default.
• W2004927896 cites W2020592733 @default.
• W2004927896 cites W2020717824 @default.
• W2004927896 cites W2026036133 @default.
• W2004927896 cites W2026531830 @default.
• W2004927896 cites W2031511295 @default.
• W2004927896 cites W2034334940 @default.
• W2004927896 cites W2040944552 @default.
• W2004927896 cites W2041527069 @default.
• W2004927896 cites W2048255506 @default.
• W2004927896 cites W2049473670 @default.
• W2004927896 cites W2055509193 @default.
• W2004927896 cites W2059766312 @default.
• W2004927896 cites W2064488401 @default.
• W2004927896 cites W2064808830 @default.
• W2004927896 cites W2065693353 @default.
• W2004927896 cites W2069887119 @default.
• W2004927896 cites W2070459309 @default.
• W2004927896 cites W2088408291 @default.
• W2004927896 cites W2090913926 @default.
• W2004927896 cites W2095586520 @default.
• W2004927896 cites W2104095017 @default.
• W2004927896 cites W2105120377 @default.
• W2004927896 cites W2118498447 @default.
• W2004927896 cites W2119814147 @default.
• W2004927896 cites W2123703790 @default.
• W2004927896 cites W2131875084 @default.
• W2004927896 cites W2138627421 @default.
• W2004927896 cites W2149682171 @default.
• W2004927896 cites W2153630542 @default.
• W2004927896 cites W2164340098 @default.
• W2004927896 cites W2177281686 @default.
• W2004927896 cites W2184638557 @default.
• W2004927896 cites W3023454987 @default.
• W2004927896 cites W4236425814 @default.
• W2004927896 cites W4236993952 @default.
• W2004927896 cites W4253924196 @default.
• W2004927896 cites W4297901344 @default.
• W2004927896 cites W4298152122 @default.
• W2004927896 doi "https://doi.org/10.1002/cbic.200200551" @default.
• W2004927896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12851928" @default.
• W2004927896 hasPublicationYear "2003" @default.
• W2004927896 type Work @default.
• W2004927896 sameAs 2004927896 @default.
• W2004927896 citedByCount "28" @default.
• W2004927896 countsByYear W20049278962012 @default.
• W2004927896 countsByYear W20049278962013 @default.
• W2004927896 countsByYear W20049278962016 @default.
• W2004927896 countsByYear W20049278962017 @default.
• W2004927896 countsByYear W20049278962018 @default.
• W2004927896 countsByYear W20049278962020 @default.
• W2004927896 countsByYear W20049278962022 @default.
• W2004927896 crossrefType "journal-article" @default.
• W2004927896 hasAuthorship W2004927896A5060495399 @default.
• W2004927896 hasAuthorship W2004927896A5069204119 @default.
• W2004927896 hasAuthorship W2004927896A5073423429 @default.
• W2004927896 hasConcept C124614425 @default.
• W2004927896 hasConcept C145148216 @default.
• W2004927896 hasConcept C155647269 @default.
• W2004927896 hasConcept C178790620 @default.
• W2004927896 hasConcept C179104552 @default.
• W2004927896 hasConcept C184651966 @default.
• W2004927896 hasConcept C184866935 @default.
• W2004927896 hasConcept C185592680 @default.
• W2004927896 hasConcept C199164860 @default.
• W2004927896 hasConcept C2777132085 @default.
• W2004927896 hasConcept C2777626080 @default.
• W2004927896 hasConcept C2778278100 @default.
• W2004927896 hasConcept C2781253882 @default.
• W2004927896 hasConcept C544153396 @default.
• W2004927896 hasConcept C71240020 @default.

• next