FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004929843> ?p ?o ?g. }

• W2004929843 endingPage "559" @default.
• W2004929843 startingPage "552" @default.
• W2004929843 abstract "Aims To evaluate the pharmacokinetics of nevirapine and any possible influencing factors in pregnant women ( n = 16), nonpregnant women ( n = 13) and men ( n = 14), who received nevirapine 200 mg twice daily together with nucleoside reverse transcriptase inhibitors. Methods Blood samples were taken for 12 h at steady state. Nevirapine concentrations were measured by liquid chromatography‐tandem mass spectrometry. The influence of gender, age, body weight and comedication on minimum and maximum concentrations ( C min , C max ), area under the concentration‐time curve (AUC), total clearance (CL tot ), half‐life ( t 1/2 ) and volume of distribution ( V d ) was analysed by multivariate techniques. Results Mean [95% confidence interval (CI)] C max , AUC ss and clearance were 5221 ng ml −1 (4267, 6175), 50 789 ng −1 h ml −1 (43 453, 58 125) and 69.9 ml min −1 for men, 5871 ng ml −1 (4848, 6895), 57 045 ng h −1 ml −1 (45 997, 68 093) and 65.6 ml min −1 for nonpregnant women and 4505 ng ml −1 (3644, 5366), 44 579 ng h −1 ml −1 (36 564, 52 594) and 82.1 ml min −1 for pregnant women. The differences between pregnant and nonpregnant women (% difference, 95% CI) in C max (−30.3; −28.5, −33.0), AUC ss (−28.0; − 25.8, − 29.5) and clearance (20.2; 26.6, 15.6) reached statistical significance ( P = 0.010, P = 0.028 and P = 0.028, respectively). The multivariate analysis underscored the influence of bodyweight on the plasma exposure to nevirapine. Conclusions Pregnant women exhibited an increased nevirapine clearance and comparably low plasma concentrations, whereas women with a low bodyweight achieved high plasma nevirapine concentrations. The large variability in nevirapine concentrations in women may lead to loss of efficacy and viral resistance, or drug toxicity, and therefore these patients should be monitored frequently." @default.
• W2004929843 created "2016-06-24" @default.
• W2004929843 creator A5013296898 @default.
• W2004929843 creator A5014312390 @default.
• W2004929843 creator A5022918770 @default.
• W2004929843 creator A5025244846 @default.
• W2004929843 creator A5038652419 @default.
• W2004929843 creator A5042403757 @default.
• W2004929843 creator A5042806386 @default.
• W2004929843 creator A5066949455 @default.
• W2004929843 creator A5070006495 @default.
• W2004929843 creator A5081613528 @default.
• W2004929843 creator A5084482226 @default.
• W2004929843 date "2006-04-26" @default.
• W2004929843 modified "2023-10-16" @default.
• W2004929843 title "A comparison of the steady-state pharmacokinetics of nevirapine in men, nonpregnant women and women in late pregnancy" @default.
• W2004929843 cites W1572621932 @default.
• W2004929843 cites W1848709375 @default.
• W2004929843 cites W1966889975 @default.
• W2004929843 cites W1993641427 @default.
• W2004929843 cites W2001964229 @default.
• W2004929843 cites W2013907757 @default.
• W2004929843 cites W2028725683 @default.
• W2004929843 cites W2034482023 @default.
• W2004929843 cites W2037065704 @default.
• W2004929843 cites W2050303897 @default.
• W2004929843 cites W2060502594 @default.
• W2004929843 cites W2074570515 @default.
• W2004929843 cites W2081171675 @default.
• W2004929843 cites W2083957232 @default.
• W2004929843 cites W2085312586 @default.
• W2004929843 cites W2109836718 @default.
• W2004929843 cites W2118020412 @default.
• W2004929843 cites W2120487911 @default.
• W2004929843 cites W2124543441 @default.
• W2004929843 cites W2138537958 @default.
• W2004929843 cites W2149653118 @default.
• W2004929843 cites W2159601567 @default.
• W2004929843 cites W2261427115 @default.
• W2004929843 cites W2320290707 @default.
• W2004929843 cites W2324423605 @default.
• W2004929843 cites W2415814777 @default.
• W2004929843 cites W2416306441 @default.
• W2004929843 cites W2474790045 @default.
• W2004929843 cites W2517787744 @default.
• W2004929843 cites W4292079232 @default.
• W2004929843 doi "https://doi.org/10.1111/j.1365-2125.2006.02664.x" @default.
• W2004929843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1885176" @default.
• W2004929843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17061962" @default.
• W2004929843 hasPublicationYear "2006" @default.
• W2004929843 type Work @default.
• W2004929843 sameAs 2004929843 @default.
• W2004929843 citedByCount "39" @default.
• W2004929843 countsByYear W20049298432012 @default.
• W2004929843 countsByYear W20049298432013 @default.
• W2004929843 countsByYear W20049298432014 @default.
• W2004929843 countsByYear W20049298432015 @default.
• W2004929843 countsByYear W20049298432016 @default.
• W2004929843 countsByYear W20049298432017 @default.
• W2004929843 countsByYear W20049298432018 @default.
• W2004929843 countsByYear W20049298432019 @default.
• W2004929843 countsByYear W20049298432021 @default.
• W2004929843 crossrefType "journal-article" @default.
• W2004929843 hasAuthorship W2004929843A5013296898 @default.
• W2004929843 hasAuthorship W2004929843A5014312390 @default.
• W2004929843 hasAuthorship W2004929843A5022918770 @default.
• W2004929843 hasAuthorship W2004929843A5025244846 @default.
• W2004929843 hasAuthorship W2004929843A5038652419 @default.
• W2004929843 hasAuthorship W2004929843A5042403757 @default.
• W2004929843 hasAuthorship W2004929843A5042806386 @default.
• W2004929843 hasAuthorship W2004929843A5066949455 @default.
• W2004929843 hasAuthorship W2004929843A5070006495 @default.
• W2004929843 hasAuthorship W2004929843A5081613528 @default.
• W2004929843 hasAuthorship W2004929843A5084482226 @default.
• W2004929843 hasBestOaLocation W20049298431 @default.
• W2004929843 hasConcept C112705442 @default.
• W2004929843 hasConcept C126322002 @default.
• W2004929843 hasConcept C134018914 @default.
• W2004929843 hasConcept C139254425 @default.
• W2004929843 hasConcept C142462285 @default.
• W2004929843 hasConcept C176674119 @default.
• W2004929843 hasConcept C203014093 @default.
• W2004929843 hasConcept C2779130552 @default.
• W2004929843 hasConcept C2779234561 @default.
• W2004929843 hasConcept C2993143319 @default.
• W2004929843 hasConcept C3013748606 @default.
• W2004929843 hasConcept C44249647 @default.
• W2004929843 hasConcept C54355233 @default.
• W2004929843 hasConcept C71924100 @default.
• W2004929843 hasConcept C86803240 @default.
• W2004929843 hasConceptScore W2004929843C112705442 @default.
• W2004929843 hasConceptScore W2004929843C126322002 @default.
• W2004929843 hasConceptScore W2004929843C134018914 @default.
• W2004929843 hasConceptScore W2004929843C139254425 @default.
• W2004929843 hasConceptScore W2004929843C142462285 @default.
• W2004929843 hasConceptScore W2004929843C176674119 @default.
• W2004929843 hasConceptScore W2004929843C203014093 @default.
• W2004929843 hasConceptScore W2004929843C2779130552 @default.

• next