Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004935908> ?p ?o ?g. }
- W2004935908 endingPage "721" @default.
- W2004935908 startingPage "715" @default.
- W2004935908 abstract "Nuclear, casein kinase and cyclin-dependent kinase substrate (NUCKS), a protein similar to the HMG (high-mobility group) protein family, is one of the most modified proteins in the mammalian proteome. Although very little is known about the biological roles of NUCKS, emerging clinical evidence suggests that this protein can be a biomarker and therapeutic target in various human ailments, including several types of cancer. An inverse correlation between NUCKS protein levels and body mass index in humans has also been observed. Depletion of NUCKS in mice has been reported to lead to obesity and impaired glucose homoeostasis. Genome-wide genomic and proteomic approaches have revealed that NUCKS is a chromatin regulator that affects transcription. The time is now ripe for further understanding of the role of this novel biomarker of cancer and the metabolic syndrome, and how its sundry modifications can affect its function. Such studies could reveal how NUCKS could be a link between physiological cues and human ailments." @default.
- W2004935908 created "2016-06-24" @default.
- W2004935908 creator A5014023198 @default.
- W2004935908 creator A5051799874 @default.
- W2004935908 creator A5066827493 @default.
- W2004935908 date "2015-03-10" @default.
- W2004935908 modified "2023-10-17" @default.
- W2004935908 title "NUCKS: a potential biomarker in cancer and metabolic disease" @default.
- W2004935908 cites W169987683 @default.
- W2004935908 cites W1965957082 @default.
- W2004935908 cites W1972293204 @default.
- W2004935908 cites W1981006493 @default.
- W2004935908 cites W1981435718 @default.
- W2004935908 cites W1984249881 @default.
- W2004935908 cites W1988818650 @default.
- W2004935908 cites W1993450321 @default.
- W2004935908 cites W2000268413 @default.
- W2004935908 cites W2001174910 @default.
- W2004935908 cites W2008416190 @default.
- W2004935908 cites W2012080767 @default.
- W2004935908 cites W2012650343 @default.
- W2004935908 cites W2015894263 @default.
- W2004935908 cites W2023245620 @default.
- W2004935908 cites W2023856223 @default.
- W2004935908 cites W2033861401 @default.
- W2004935908 cites W2037654470 @default.
- W2004935908 cites W2039276157 @default.
- W2004935908 cites W2039779964 @default.
- W2004935908 cites W2041825762 @default.
- W2004935908 cites W2043204177 @default.
- W2004935908 cites W2043583883 @default.
- W2004935908 cites W2043916693 @default.
- W2004935908 cites W2050488981 @default.
- W2004935908 cites W2057183395 @default.
- W2004935908 cites W2060433653 @default.
- W2004935908 cites W2060644939 @default.
- W2004935908 cites W2065099733 @default.
- W2004935908 cites W2072470895 @default.
- W2004935908 cites W2073701388 @default.
- W2004935908 cites W2075877405 @default.
- W2004935908 cites W2078945029 @default.
- W2004935908 cites W2083078175 @default.
- W2004935908 cites W2083409948 @default.
- W2004935908 cites W2086658333 @default.
- W2004935908 cites W2093275886 @default.
- W2004935908 cites W2102482497 @default.
- W2004935908 cites W2104726963 @default.
- W2004935908 cites W2110251865 @default.
- W2004935908 cites W2112651502 @default.
- W2004935908 cites W2115604365 @default.
- W2004935908 cites W2129777487 @default.
- W2004935908 cites W2130355910 @default.
- W2004935908 cites W2131377076 @default.
- W2004935908 cites W2138147811 @default.
- W2004935908 cites W2145079074 @default.
- W2004935908 cites W2152750160 @default.
- W2004935908 cites W2154417639 @default.
- W2004935908 cites W2162691829 @default.
- W2004935908 cites W2164928543 @default.
- W2004935908 cites W2166219476 @default.
- W2004935908 cites W2167823708 @default.
- W2004935908 cites W2170140374 @default.
- W2004935908 cites W2172012754 @default.
- W2004935908 doi "https://doi.org/10.1042/cs20140656" @default.
- W2004935908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25760963" @default.
- W2004935908 hasPublicationYear "2015" @default.
- W2004935908 type Work @default.
- W2004935908 sameAs 2004935908 @default.
- W2004935908 citedByCount "18" @default.
- W2004935908 countsByYear W20049359082015 @default.
- W2004935908 countsByYear W20049359082016 @default.
- W2004935908 countsByYear W20049359082017 @default.
- W2004935908 countsByYear W20049359082018 @default.
- W2004935908 countsByYear W20049359082019 @default.
- W2004935908 countsByYear W20049359082020 @default.
- W2004935908 countsByYear W20049359082021 @default.
- W2004935908 countsByYear W20049359082022 @default.
- W2004935908 countsByYear W20049359082023 @default.
- W2004935908 crossrefType "journal-article" @default.
- W2004935908 hasAuthorship W2004935908A5014023198 @default.
- W2004935908 hasAuthorship W2004935908A5051799874 @default.
- W2004935908 hasAuthorship W2004935908A5066827493 @default.
- W2004935908 hasConcept C104317684 @default.
- W2004935908 hasConcept C104397665 @default.
- W2004935908 hasConcept C126322002 @default.
- W2004935908 hasConcept C184235292 @default.
- W2004935908 hasConcept C2779134260 @default.
- W2004935908 hasConcept C2781197716 @default.
- W2004935908 hasConcept C502942594 @default.
- W2004935908 hasConcept C54355233 @default.
- W2004935908 hasConcept C60644358 @default.
- W2004935908 hasConcept C6929976 @default.
- W2004935908 hasConcept C70721500 @default.
- W2004935908 hasConcept C71924100 @default.
- W2004935908 hasConcept C86339819 @default.
- W2004935908 hasConcept C86803240 @default.
- W2004935908 hasConcept C95444343 @default.
- W2004935908 hasConceptScore W2004935908C104317684 @default.