Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004949031> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2004949031 endingPage "e0123564" @default.
- W2004949031 startingPage "e0123564" @default.
- W2004949031 abstract "Yersiniosis caused by Yersinia enterocolitica has been reported from all continents. The bacterial species is divided into more than fifty serovars and six biovars viz. 1A, 1B, 2, 3, 4 and 5 which differ in geographical distribution, ecological niches and pathogenicity. Most Y.enterocolitica strains harbor chromosomal genes for two β-lactamases, blaA an Ambler class A penicillinase and blaB an Ambler class C inducible cephalosporinase. In the present study, susceptibility to b-lactam antibiotics and β-lactamase inhibitor was studied for Y. enterocolitica strains of biovars 1A, 1B, 2 and 4. We observed that β-lactamases were expressed differentially among strains of different biovars. To understand the molecular mechanisms underlying such differential expression, the sequences of genes and promoters of blaA were compared. Also, the variants of blaA present in different biovars were modeled and docked with amoxicillin and clavulanic acid. The mRNA secondary structures of blaA variants were also predicted in-silico. Our findings indicated that neither variations in the promoter regions, nor the secondary structures of mRNA contributed to higher/lower expression of blaA in different biovars. Analysis of H-bonding residues of blaA variants with amoxicillin and clavulanic acid revealed that if amino acid residues of a β-lactamase interacting with amoxicillin and the clavulanic acid were similar, clavulanic acid was effective in engaging the enzyme, accounting for a significant reduction in MIC of amoxicillin-clavulanate. This finding might aid in designing better β-lactamase inhibitors with improved efficiencies in future." @default.
- W2004949031 created "2016-06-24" @default.
- W2004949031 creator A5019181731 @default.
- W2004949031 creator A5045186073 @default.
- W2004949031 creator A5051679664 @default.
- W2004949031 creator A5074875822 @default.
- W2004949031 date "2015-04-28" @default.
- W2004949031 modified "2023-09-24" @default.
- W2004949031 title "Structural Variabilities in β-Lactamase (blaA) of Different Biovars of Yersinia enterocolitica: Implications for β-Lactam Antibiotic and β-Lactamase Inhibitor Susceptibilities" @default.
- W2004949031 cites W1986191025 @default.
- W2004949031 cites W1990039085 @default.
- W2004949031 cites W1994608774 @default.
- W2004949031 cites W1997624749 @default.
- W2004949031 cites W1998296574 @default.
- W2004949031 cites W2004195474 @default.
- W2004949031 cites W2013526237 @default.
- W2004949031 cites W2053171202 @default.
- W2004949031 cites W2062917140 @default.
- W2004949031 cites W2065920818 @default.
- W2004949031 cites W2071486470 @default.
- W2004949031 cites W2086779432 @default.
- W2004949031 cites W2101142786 @default.
- W2004949031 cites W2145491097 @default.
- W2004949031 cites W2317667239 @default.
- W2004949031 doi "https://doi.org/10.1371/journal.pone.0123564" @default.
- W2004949031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4414059" @default.
- W2004949031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25919756" @default.
- W2004949031 hasPublicationYear "2015" @default.
- W2004949031 type Work @default.
- W2004949031 sameAs 2004949031 @default.
- W2004949031 citedByCount "2" @default.
- W2004949031 countsByYear W20049490312017 @default.
- W2004949031 countsByYear W20049490312021 @default.
- W2004949031 crossrefType "journal-article" @default.
- W2004949031 hasAuthorship W2004949031A5019181731 @default.
- W2004949031 hasAuthorship W2004949031A5045186073 @default.
- W2004949031 hasAuthorship W2004949031A5051679664 @default.
- W2004949031 hasAuthorship W2004949031A5074875822 @default.
- W2004949031 hasBestOaLocation W20049490311 @default.
- W2004949031 hasConcept C2776234502 @default.
- W2004949031 hasConcept C2779454058 @default.
- W2004949031 hasConcept C2779708577 @default.
- W2004949031 hasConcept C501593827 @default.
- W2004949031 hasConcept C523546767 @default.
- W2004949031 hasConcept C54355233 @default.
- W2004949031 hasConcept C86803240 @default.
- W2004949031 hasConcept C89423630 @default.
- W2004949031 hasConceptScore W2004949031C2776234502 @default.
- W2004949031 hasConceptScore W2004949031C2779454058 @default.
- W2004949031 hasConceptScore W2004949031C2779708577 @default.
- W2004949031 hasConceptScore W2004949031C501593827 @default.
- W2004949031 hasConceptScore W2004949031C523546767 @default.
- W2004949031 hasConceptScore W2004949031C54355233 @default.
- W2004949031 hasConceptScore W2004949031C86803240 @default.
- W2004949031 hasConceptScore W2004949031C89423630 @default.
- W2004949031 hasIssue "4" @default.
- W2004949031 hasLocation W20049490311 @default.
- W2004949031 hasLocation W20049490312 @default.
- W2004949031 hasLocation W20049490313 @default.
- W2004949031 hasLocation W20049490314 @default.
- W2004949031 hasLocation W20049490315 @default.
- W2004949031 hasOpenAccess W2004949031 @default.
- W2004949031 hasPrimaryLocation W20049490311 @default.
- W2004949031 hasRelatedWork W2080345264 @default.
- W2004949031 hasRelatedWork W2128926754 @default.
- W2004949031 hasRelatedWork W2140053948 @default.
- W2004949031 hasRelatedWork W2288622746 @default.
- W2004949031 hasRelatedWork W2392274759 @default.
- W2004949031 hasRelatedWork W2969569864 @default.
- W2004949031 hasRelatedWork W3087807016 @default.
- W2004949031 hasRelatedWork W4310714881 @default.
- W2004949031 hasRelatedWork W2189095281 @default.
- W2004949031 hasRelatedWork W2768888346 @default.
- W2004949031 hasVolume "10" @default.
- W2004949031 isParatext "false" @default.
- W2004949031 isRetracted "false" @default.
- W2004949031 magId "2004949031" @default.
- W2004949031 workType "article" @default.