FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004971567> ?p ?o ?g. }

• W2004971567 endingPage "e5" @default.
• W2004971567 startingPage "e5" @default.
• W2004971567 abstract "Current modifications used in small interfering RNAs (siRNAs), such as 2'-methoxy (2'-OMe) and 2'-fluoro (2'-F), improve stability, specificity or immunogenic properties but do not improve potency. These modifications were previously designed for use in antisense and not siRNA. We show, for the first time, that the siRNA-optimized novel 2'-O modifications, 2'-O-benzyl, and 2'-O-methyl-4-pyridine (2'-O-CH2Py(4)), are tolerated at multiple positions on the guide strand of siRNA sequences in vivo. 2'-O-benzyl and 2'-O-CH2Py(4) modifications were tested at each position individually along the guide strand in five sequences to determine positions that tolerated the modifications. The positions were combined together and found to increase potency and duration of siRNAs in vivo compared to their unmodified counterparts when delivered using lipid nanoparticles. For 2'-O-benzyl, four incorporations were tolerated with similar activity to the unmodified siRNA in vivo, while for 2'-O-CH2Py(4) six incorporations were tolerated. Increased in vivo activity was observed when the modifications were combined at positions 8 and 15 on the guide strand. Understanding the optimal placement of siRNA-optimized modifications needed for maximal in vivo activity is necessary for development of RNA-based therapeutics." @default.
• W2004971567 created "2016-06-24" @default.
• W2004971567 creator A5003848085 @default.
• W2004971567 creator A5021680688 @default.
• W2004971567 creator A5027476065 @default.
• W2004971567 creator A5030870870 @default.
• W2004971567 creator A5059293050 @default.
• W2004971567 creator A5059734311 @default.
• W2004971567 creator A5062383800 @default.
• W2004971567 creator A5068876322 @default.
• W2004971567 creator A5078982301 @default.
• W2004971567 date "2012-01-01" @default.
• W2004971567 modified "2023-10-17" @default.
• W2004971567 title "siRNA-optimized Modifications for Enhanced In Vivo Activity" @default.
• W2004971567 cites W1501059295 @default.
• W2004971567 cites W1972637758 @default.
• W2004971567 cites W1984085632 @default.
• W2004971567 cites W1988471700 @default.
• W2004971567 cites W1996395749 @default.
• W2004971567 cites W2008426300 @default.
• W2004971567 cites W2009542107 @default.
• W2004971567 cites W2009572131 @default.
• W2004971567 cites W2014557438 @default.
• W2004971567 cites W2016272344 @default.
• W2004971567 cites W2023246459 @default.
• W2004971567 cites W2034709592 @default.
• W2004971567 cites W2035487809 @default.
• W2004971567 cites W2053458681 @default.
• W2004971567 cites W2054166086 @default.
• W2004971567 cites W2079985532 @default.
• W2004971567 cites W2082213106 @default.
• W2004971567 cites W2102694589 @default.
• W2004971567 cites W2104944750 @default.
• W2004971567 cites W2108787892 @default.
• W2004971567 cites W2111066814 @default.
• W2004971567 cites W2112380183 @default.
• W2004971567 cites W2121133384 @default.
• W2004971567 cites W2142327734 @default.
• W2004971567 cites W2143313350 @default.
• W2004971567 cites W2157287222 @default.
• W2004971567 cites W2158605421 @default.
• W2004971567 cites W2159595055 @default.
• W2004971567 cites W2161560970 @default.
• W2004971567 cites W2166915947 @default.
• W2004971567 cites W2168993612 @default.
• W2004971567 cites W2312877065 @default.
• W2004971567 cites W2318791227 @default.
• W2004971567 cites W2329086168 @default.
• W2004971567 doi "https://doi.org/10.1038/mtna.2011.4" @default.
• W2004971567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3381598" @default.
• W2004971567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23344622" @default.
• W2004971567 hasPublicationYear "2012" @default.
• W2004971567 type Work @default.
• W2004971567 sameAs 2004971567 @default.
• W2004971567 citedByCount "72" @default.
• W2004971567 countsByYear W20049715672013 @default.
• W2004971567 countsByYear W20049715672014 @default.
• W2004971567 countsByYear W20049715672015 @default.
• W2004971567 countsByYear W20049715672016 @default.
• W2004971567 countsByYear W20049715672017 @default.
• W2004971567 countsByYear W20049715672018 @default.
• W2004971567 countsByYear W20049715672019 @default.
• W2004971567 countsByYear W20049715672020 @default.
• W2004971567 countsByYear W20049715672021 @default.
• W2004971567 countsByYear W20049715672022 @default.
• W2004971567 countsByYear W20049715672023 @default.
• W2004971567 crossrefType "journal-article" @default.
• W2004971567 hasAuthorship W2004971567A5003848085 @default.
• W2004971567 hasAuthorship W2004971567A5021680688 @default.
• W2004971567 hasAuthorship W2004971567A5027476065 @default.
• W2004971567 hasAuthorship W2004971567A5030870870 @default.
• W2004971567 hasAuthorship W2004971567A5059293050 @default.
• W2004971567 hasAuthorship W2004971567A5059734311 @default.
• W2004971567 hasAuthorship W2004971567A5062383800 @default.
• W2004971567 hasAuthorship W2004971567A5068876322 @default.
• W2004971567 hasAuthorship W2004971567A5078982301 @default.
• W2004971567 hasBestOaLocation W20049715671 @default.
• W2004971567 hasConcept C104317684 @default.
• W2004971567 hasConcept C153911025 @default.
• W2004971567 hasConcept C166703698 @default.
• W2004971567 hasConcept C185592680 @default.
• W2004971567 hasConcept C202751555 @default.
• W2004971567 hasConcept C207001950 @default.
• W2004971567 hasConcept C22615655 @default.
• W2004971567 hasConcept C54355233 @default.
• W2004971567 hasConcept C55493867 @default.
• W2004971567 hasConcept C57992300 @default.
• W2004971567 hasConcept C67705224 @default.
• W2004971567 hasConcept C86803240 @default.
• W2004971567 hasConcept C98274493 @default.
• W2004971567 hasConceptScore W2004971567C104317684 @default.
• W2004971567 hasConceptScore W2004971567C153911025 @default.
• W2004971567 hasConceptScore W2004971567C166703698 @default.
• W2004971567 hasConceptScore W2004971567C185592680 @default.
• W2004971567 hasConceptScore W2004971567C202751555 @default.
• W2004971567 hasConceptScore W2004971567C207001950 @default.
• W2004971567 hasConceptScore W2004971567C22615655 @default.
• W2004971567 hasConceptScore W2004971567C54355233 @default.

• next