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• W2004980395 abstract "The most recently discovered serotonin (5-HT) receptor subtype, 5-HT(7), is considered to be associated with several CNS disorders. Noninvasive in vivo positron emission tomography (PET) studies of cerebral 5-HT(7) receptors could provide a significant advance in the understanding of the neurobiology and eventual dysfunctions of the 5-HT(7) receptor. To date, no appropriate 5-HT(7) receptor PET ligand has been developed. Here, we modified known 5-HT(7) selective phenylpiperazinyl-butyloxindole derivatives so that they may be labeled either with carbon-11 or fluorine-18. A set of potential 5-HT(7) ligands for PET molecular imaging was successfully synthesized. Two compounds (10 and 14) were tested against a range of targets. Both compounds display a promising in vitro profile with respect to PET imaging of the 5-HT(7) receptor in thalamic regions." @default.
• W2004980395 created "2016-06-24" @default.
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• W2004980395 date "2012-09-11" @default.
• W2004980395 modified "2023-09-27" @default.
• W2004980395 title "Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT₇ Receptor Imaging with PET" @default.
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• W2004980395 doi "https://doi.org/10.1021/cn3001137" @default.
• W2004980395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3526961" @default.
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