FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004982081> ?p ?o ?g. }

• W2004982081 endingPage "694" @default.
• W2004982081 startingPage "683" @default.
• W2004982081 abstract "The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids (GCs) are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and restore homeostasis after the immediate threat has subsided. Release of GCs is mediated by the hypothalamo–pituitary–adrenocortical (HPA) axis, driven by a neural signal originating in the paraventricular nucleus (PVN). Stress levels of GCs bind to glucocorticoid receptors (GRs) in multiple body compartments, including brain, and consequently have wide-reaching actions. For this reason, GCs serve a vital function in feedback inhibition of their own secretion. Fast, non-genomic feedback inhibition of the HPA axis is mediated at least in part by GC signaling in the PVN, acting by a cannabinoid-dependent mechanism to rapidly reduce both neural activity and GC release. Delayed feedback termination of the HPA axis response is mediated by forebrain GRs, presumably by genomic mechanisms. GCs also act in the brainstem to attenuate neuropeptidergic excitatory input to the PVN via acceleration of mRNA degradation, providing a mechanism to attenuate future responses to stressors. Thus, rather than having a single defined feedback switch, GCs work through multiple neurocircuits and signaling mechanisms to coordinate HPA axis activity to suit the overall needs of multiple body systems." @default.
• W2004982081 created "2016-06-24" @default.
• W2004982081 creator A5044618709 @default.
• W2004982081 creator A5056855507 @default.
• W2004982081 creator A5088605973 @default.
• W2004982081 date "2012-02-01" @default.
• W2004982081 modified "2023-10-18" @default.
• W2004982081 title "Neural Regulation of the Stress Response: The Many Faces of Feedback" @default.
• W2004982081 cites W122792336 @default.
• W2004982081 cites W1482114328 @default.
• W2004982081 cites W1521382255 @default.
• W2004982081 cites W1547358456 @default.
• W2004982081 cites W1754265819 @default.
• W2004982081 cites W1760946711 @default.
• W2004982081 cites W1907295447 @default.
• W2004982081 cites W1958860054 @default.
• W2004982081 cites W1963910089 @default.
• W2004982081 cites W1965865206 @default.
• W2004982081 cites W1965882160 @default.
• W2004982081 cites W1966464425 @default.
• W2004982081 cites W1967122944 @default.
• W2004982081 cites W1967186684 @default.
• W2004982081 cites W1967207437 @default.
• W2004982081 cites W1967562551 @default.
• W2004982081 cites W1970504819 @default.
• W2004982081 cites W1973676618 @default.
• W2004982081 cites W1973783162 @default.
• W2004982081 cites W1976839538 @default.
• W2004982081 cites W1977143695 @default.
• W2004982081 cites W1977774953 @default.
• W2004982081 cites W1978599015 @default.
• W2004982081 cites W1979295154 @default.
• W2004982081 cites W1979655192 @default.
• W2004982081 cites W1981453234 @default.
• W2004982081 cites W1985708693 @default.
• W2004982081 cites W1987515936 @default.
• W2004982081 cites W1988860179 @default.
• W2004982081 cites W1991713558 @default.
• W2004982081 cites W1995972738 @default.
• W2004982081 cites W1998923468 @default.
• W2004982081 cites W2000081665 @default.
• W2004982081 cites W2000152465 @default.
• W2004982081 cites W2001808016 @default.
• W2004982081 cites W2002029012 @default.
• W2004982081 cites W2005097651 @default.
• W2004982081 cites W2007041596 @default.
• W2004982081 cites W2008106418 @default.
• W2004982081 cites W2008280777 @default.
• W2004982081 cites W2009053293 @default.
• W2004982081 cites W2009999305 @default.
• W2004982081 cites W2010988345 @default.
• W2004982081 cites W2012483271 @default.
• W2004982081 cites W2013384613 @default.
• W2004982081 cites W2013556329 @default.
• W2004982081 cites W2013586816 @default.
• W2004982081 cites W2015702208 @default.
• W2004982081 cites W2016770411 @default.
• W2004982081 cites W2016871471 @default.
• W2004982081 cites W2017103890 @default.
• W2004982081 cites W2017441041 @default.
• W2004982081 cites W2019101304 @default.
• W2004982081 cites W2021990516 @default.
• W2004982081 cites W2023777683 @default.
• W2004982081 cites W2024546597 @default.
• W2004982081 cites W2027075671 @default.
• W2004982081 cites W2028540781 @default.
• W2004982081 cites W2029114498 @default.
• W2004982081 cites W2035392570 @default.
• W2004982081 cites W2038459152 @default.
• W2004982081 cites W2038799752 @default.
• W2004982081 cites W2040792002 @default.
• W2004982081 cites W2041622152 @default.
• W2004982081 cites W2041699129 @default.
• W2004982081 cites W2041736210 @default.
• W2004982081 cites W2042045791 @default.
• W2004982081 cites W2042434940 @default.
• W2004982081 cites W2044196172 @default.
• W2004982081 cites W2045600065 @default.
• W2004982081 cites W2046818677 @default.
• W2004982081 cites W2046960533 @default.
• W2004982081 cites W2047693358 @default.
• W2004982081 cites W2047723877 @default.
• W2004982081 cites W2048121958 @default.
• W2004982081 cites W2049578370 @default.
• W2004982081 cites W2050444757 @default.
• W2004982081 cites W2050560847 @default.
• W2004982081 cites W2051715358 @default.
• W2004982081 cites W2051831861 @default.
• W2004982081 cites W2051859809 @default.
• W2004982081 cites W2054134853 @default.
• W2004982081 cites W2055519475 @default.
• W2004982081 cites W2055772777 @default.
• W2004982081 cites W2056777590 @default.
• W2004982081 cites W2059216322 @default.
• W2004982081 cites W2059648509 @default.
• W2004982081 cites W2061478482 @default.
• W2004982081 cites W2062171323 @default.
• W2004982081 cites W2062670482 @default.

• next