FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004990123> ?p ?o ?g. }

• W2004990123 endingPage "367" @default.
• W2004990123 startingPage "357" @default.
• W2004990123 abstract "The pineal hormone melatonin regulates circadian rhythms, largely by feedback on the central biological clock of the brain, the hypothalamic suprachiasmatic nucleus (SCN). This feedback is mediated by the melatonin receptors, melatonin receptor 1 (MT1) and melatonin receptor 2 (MT2). The circadian system may play a role in the pathophysiology of mood disorders, and indeed, melatonin-receptor agonists are considered a potential therapy for depression. In order to investigate melatonin receptors in the SCN during depression, and their relationship to the major neuropeptides in the SCN, vasopressin (AVP) and vasoactive intestinal peptide (VIP), we studied the SCN in 14 depressed patients (five major depression and nine bipolar disorder) and 14 matched controls by immunocytochemistry. We show here that hypothalamic MT2 receptor immunoreactivity was limited to SCN, the supraoptic nucleus and paraventricular nucleus. We found that numbers of MT1-immunoreactive (MT1-ir) cells and AVP and/or VIP-ir cells were increased in the central SCN in depression, but numbers of MT2-ir cells were not altered. Moreover, the number of MT1-ir cells, but not MT2-ir cells was negatively correlated with age at onset of depression, while positively correlated with disease duration. Although every post-mortem study has limitations, MT1 receptors appeared specifically increased in the SCN of depressed patients, and may increase during the course of the disease. These changes may be involved in the circadian disorders and contribute to the efficacy of MT agonists or melatonin in depression. Moreover, we suggest that melatonin receptor agonists for depression should be targeted towards the MT1 receptor selectively." @default.
• W2004990123 created "2016-06-24" @default.
• W2004990123 creator A5017745894 @default.
• W2004990123 creator A5022306053 @default.
• W2004990123 creator A5022786999 @default.
• W2004990123 creator A5026108717 @default.
• W2004990123 creator A5052712397 @default.
• W2004990123 creator A5064018437 @default.
• W2004990123 creator A5071088644 @default.
• W2004990123 creator A5089287661 @default.
• W2004990123 date "2013-06-01" @default.
• W2004990123 modified "2023-10-16" @default.
• W2004990123 title "Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression" @default.
• W2004990123 cites W1538008426 @default.
• W2004990123 cites W1594539812 @default.
• W2004990123 cites W1821913765 @default.
• W2004990123 cites W1852348769 @default.
• W2004990123 cites W1884732005 @default.
• W2004990123 cites W1966006827 @default.
• W2004990123 cites W1968910255 @default.
• W2004990123 cites W1976971186 @default.
• W2004990123 cites W1983678314 @default.
• W2004990123 cites W1985887193 @default.
• W2004990123 cites W1986419052 @default.
• W2004990123 cites W1986735688 @default.
• W2004990123 cites W1989000532 @default.
• W2004990123 cites W1993602125 @default.
• W2004990123 cites W1994222618 @default.
• W2004990123 cites W1996679288 @default.
• W2004990123 cites W2011925229 @default.
• W2004990123 cites W2013946239 @default.
• W2004990123 cites W2014763859 @default.
• W2004990123 cites W2018613585 @default.
• W2004990123 cites W2019955714 @default.
• W2004990123 cites W2021772552 @default.
• W2004990123 cites W2022032351 @default.
• W2004990123 cites W2023689431 @default.
• W2004990123 cites W2034348289 @default.
• W2004990123 cites W2035950441 @default.
• W2004990123 cites W2039169515 @default.
• W2004990123 cites W2039744210 @default.
• W2004990123 cites W2041263807 @default.
• W2004990123 cites W2044315129 @default.
• W2004990123 cites W2047451889 @default.
• W2004990123 cites W2047932022 @default.
• W2004990123 cites W2053414344 @default.
• W2004990123 cites W2054226412 @default.
• W2004990123 cites W2058331036 @default.
• W2004990123 cites W2059115988 @default.
• W2004990123 cites W2060126636 @default.
• W2004990123 cites W2063787166 @default.
• W2004990123 cites W2065080899 @default.
• W2004990123 cites W2065993271 @default.
• W2004990123 cites W2071007063 @default.
• W2004990123 cites W2071839559 @default.
• W2004990123 cites W2074557491 @default.
• W2004990123 cites W2076623230 @default.
• W2004990123 cites W2078269918 @default.
• W2004990123 cites W2078396742 @default.
• W2004990123 cites W2082186207 @default.
• W2004990123 cites W2085638975 @default.
• W2004990123 cites W2086909446 @default.
• W2004990123 cites W2089248332 @default.
• W2004990123 cites W2089650868 @default.
• W2004990123 cites W2096579248 @default.
• W2004990123 cites W2099766655 @default.
• W2004990123 cites W2099787261 @default.
• W2004990123 cites W2105839562 @default.
• W2004990123 cites W2106497761 @default.
• W2004990123 cites W2112139446 @default.
• W2004990123 cites W2114707992 @default.
• W2004990123 cites W2115218756 @default.
• W2004990123 cites W2123329342 @default.
• W2004990123 cites W2139154756 @default.
• W2004990123 cites W2142802556 @default.
• W2004990123 cites W2144411579 @default.
• W2004990123 cites W2145111083 @default.
• W2004990123 cites W2162213214 @default.
• W2004990123 cites W2409513133 @default.
• W2004990123 doi "https://doi.org/10.1016/j.jad.2012.12.025" @default.
• W2004990123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23357659" @default.
• W2004990123 hasPublicationYear "2013" @default.
• W2004990123 type Work @default.
• W2004990123 sameAs 2004990123 @default.
• W2004990123 citedByCount "99" @default.
• W2004990123 countsByYear W20049901232013 @default.
• W2004990123 countsByYear W20049901232014 @default.
• W2004990123 countsByYear W20049901232015 @default.
• W2004990123 countsByYear W20049901232016 @default.
• W2004990123 countsByYear W20049901232017 @default.
• W2004990123 countsByYear W20049901232018 @default.
• W2004990123 countsByYear W20049901232019 @default.
• W2004990123 countsByYear W20049901232020 @default.
• W2004990123 countsByYear W20049901232021 @default.
• W2004990123 countsByYear W20049901232022 @default.
• W2004990123 countsByYear W20049901232023 @default.
• W2004990123 crossrefType "journal-article" @default.
• W2004990123 hasAuthorship W2004990123A5017745894 @default.

• next