FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004990970> ?p ?o ?g. }

• W2004990970 endingPage "2770" @default.
• W2004990970 startingPage "2764" @default.
• W2004990970 abstract "Avian coccidiosis is mostly caused by mixed infection of several Eimeria species under natural conditions and immunity to avian coccidiosis is largely dependent on T-cell immune response. In this study, 14 T-cell epitope fragments from eight antigens of Eimeria tenella (E. tenella), Eimeria necatrix (E. necatrix), Eimeria maxima (E. maxima) and Eimeria acervulina (E. acervulina) were ligated with pVAX1 producing 14 monovalent DNA vaccines, respectively. Protective immunity of the monovalent DNA vaccines was assessed by in vivo challenge experiments and then four most protective fragments of each species were chosen to construct multivalent epitope DNA vaccines with or without chicken IL-2 as genetic adjuvant. Protective efficacies of the epitope DNA vaccines on chickens against E. tenella, E. necatrix, E. maxima and E. acervulina were evaluated. The results showed that the constructed multivalent epitope DNA vaccines significantly increased body weight gain, alleviated enteric lesions and reduced oocyst output of the infected birds. Especially, the multivalent epitope DNA vaccines of pVAX1-NA4-1-TA4-1-LDH-2-EMCDPK-1 and pVAX1-NA4-1-TA4-1-LDH-2-EMCDPK-1-IL-2 not only significantly increased body weight gain, alleviated enteric lesions and reduced oocyst output of the infected birds, but also resulted in anti-coccidial index (ACI) more than 170 against E. tenella, E. necatrix, E. maxima and E. acervulina, which indicated they could induce protective immunity against E. tenella, E. necatrix, E. maxima and E. acervulina. Our findings suggest the constructed multivalent epitope DNA vaccines are the potential candidate multivalent vaccines against mixed infection of Eimeria." @default.
• W2004990970 created "2016-06-24" @default.
• W2004990970 creator A5033133176 @default.
• W2004990970 creator A5037765953 @default.
• W2004990970 creator A5038699958 @default.
• W2004990970 creator A5066281981 @default.
• W2004990970 creator A5084078237 @default.
• W2004990970 date "2015-06-01" @default.
• W2004990970 modified "2023-09-23" @default.
• W2004990970 title "Induction of protective immunity against Eimeria tenella, Eimeria necatrix, Eimeria maxima and Eimeria acervulina infections using multivalent epitope DNA vaccines" @default.
• W2004990970 cites W1498340710 @default.
• W2004990970 cites W153972386 @default.
• W2004990970 cites W1587920056 @default.
• W2004990970 cites W1915480644 @default.
• W2004990970 cites W1974636525 @default.
• W2004990970 cites W1987263704 @default.
• W2004990970 cites W1988130478 @default.
• W2004990970 cites W1992549774 @default.
• W2004990970 cites W1998941879 @default.
• W2004990970 cites W1999953528 @default.
• W2004990970 cites W2007487171 @default.
• W2004990970 cites W2013944635 @default.
• W2004990970 cites W2015743863 @default.
• W2004990970 cites W2018296894 @default.
• W2004990970 cites W2025780168 @default.
• W2004990970 cites W2029976175 @default.
• W2004990970 cites W2030006861 @default.
• W2004990970 cites W2031413584 @default.
• W2004990970 cites W2041394108 @default.
• W2004990970 cites W2042459359 @default.
• W2004990970 cites W2047186860 @default.
• W2004990970 cites W2050459209 @default.
• W2004990970 cites W2051402309 @default.
• W2004990970 cites W2051615518 @default.
• W2004990970 cites W2068586926 @default.
• W2004990970 cites W2070461225 @default.
• W2004990970 cites W2074706498 @default.
• W2004990970 cites W2077883112 @default.
• W2004990970 cites W2088762091 @default.
• W2004990970 cites W2088762579 @default.
• W2004990970 cites W2092590459 @default.
• W2004990970 cites W2095109540 @default.
• W2004990970 cites W2105229259 @default.
• W2004990970 cites W2146041009 @default.
• W2004990970 cites W2153792939 @default.
• W2004990970 cites W2169409695 @default.
• W2004990970 cites W2333279571 @default.
• W2004990970 doi "https://doi.org/10.1016/j.vaccine.2015.04.052" @default.
• W2004990970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25921712" @default.
• W2004990970 hasPublicationYear "2015" @default.
• W2004990970 type Work @default.
• W2004990970 sameAs 2004990970 @default.
• W2004990970 citedByCount "27" @default.
• W2004990970 countsByYear W20049909702015 @default.
• W2004990970 countsByYear W20049909702016 @default.
• W2004990970 countsByYear W20049909702017 @default.
• W2004990970 countsByYear W20049909702018 @default.
• W2004990970 countsByYear W20049909702019 @default.
• W2004990970 countsByYear W20049909702020 @default.
• W2004990970 countsByYear W20049909702021 @default.
• W2004990970 countsByYear W20049909702022 @default.
• W2004990970 crossrefType "journal-article" @default.
• W2004990970 hasAuthorship W2004990970A5033133176 @default.
• W2004990970 hasAuthorship W2004990970A5037765953 @default.
• W2004990970 hasAuthorship W2004990970A5038699958 @default.
• W2004990970 hasAuthorship W2004990970A5066281981 @default.
• W2004990970 hasAuthorship W2004990970A5084078237 @default.
• W2004990970 hasConcept C147483822 @default.
• W2004990970 hasConcept C159047783 @default.
• W2004990970 hasConcept C167508917 @default.
• W2004990970 hasConcept C195616568 @default.
• W2004990970 hasConcept C203014093 @default.
• W2004990970 hasConcept C2776576699 @default.
• W2004990970 hasConcept C2777976947 @default.
• W2004990970 hasConcept C2778773781 @default.
• W2004990970 hasConcept C2779310134 @default.
• W2004990970 hasConcept C2779341262 @default.
• W2004990970 hasConcept C2780801004 @default.
• W2004990970 hasConcept C42972112 @default.
• W2004990970 hasConcept C71924100 @default.
• W2004990970 hasConcept C86803240 @default.
• W2004990970 hasConcept C8891405 @default.
• W2004990970 hasConcept C89423630 @default.
• W2004990970 hasConceptScore W2004990970C147483822 @default.
• W2004990970 hasConceptScore W2004990970C159047783 @default.
• W2004990970 hasConceptScore W2004990970C167508917 @default.
• W2004990970 hasConceptScore W2004990970C195616568 @default.
• W2004990970 hasConceptScore W2004990970C203014093 @default.
• W2004990970 hasConceptScore W2004990970C2776576699 @default.
• W2004990970 hasConceptScore W2004990970C2777976947 @default.
• W2004990970 hasConceptScore W2004990970C2778773781 @default.
• W2004990970 hasConceptScore W2004990970C2779310134 @default.
• W2004990970 hasConceptScore W2004990970C2779341262 @default.
• W2004990970 hasConceptScore W2004990970C2780801004 @default.
• W2004990970 hasConceptScore W2004990970C42972112 @default.
• W2004990970 hasConceptScore W2004990970C71924100 @default.
• W2004990970 hasConceptScore W2004990970C86803240 @default.
• W2004990970 hasConceptScore W2004990970C8891405 @default.

• next