Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004994018> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2004994018 abstract "Two homologs of the gene encoding the adrenocortical 21-hydroxylase (21-OHase) are located within the S region of the mouse major histocompatibility complex. Only one of these homologs, however, encoded the full-length sequence of 21-OHase, directed the synthesis of 21-OHase RNA in the mouse adrenal gland, and was capable of restoring 21-OHase activity when transfected into 21-OHase-deficient Y1 adrenocortical tumor cells. Y1 cells transfected with the 21-OHase gene, when stimulated with ACTH, increased the number of 21-OHase transcripts up to 10-fold. The 21-OHase gene was not expressed when transfected into mouse fibroblast L cells, and was poorly expressed and poorly regulated by ACTH when transfected into a Y1 mutant harboring a defective cAMP-dependent protein kinase. Marked decreases in expression of the 21-OHase gene were noted when DNA constructs that contained fewer than 230 base pairs in the 5' flanking region of the gene were transfected into Y1 cells. These results indicate that the 21-OHase gene encodes information required for the tissue-specific expression and hormonal regulation of 21-OHase. The cAMP-dependent protein kinase is important for both aspects of gene expression. At most, 230 base pairs of 5' non-coding information are required for efficient expression of the 21-OHase gene in Y1 cells." @default.
- W2004994018 created "2016-06-24" @default.
- W2004994018 creator A5002254138 @default.
- W2004994018 creator A5038079945 @default.
- W2004994018 creator A5048869732 @default.
- W2004994018 creator A5071796896 @default.
- W2004994018 creator A5090268027 @default.
- W2004994018 date "1986-01-01" @default.
- W2004994018 modified "2023-10-17" @default.
- W2004994018 title "Molecular Analysis of 21-Hydroxylase Gene Expression in Mouse Adrenal Cells" @default.
- W2004994018 cites W1556752176 @default.
- W2004994018 cites W1963680434 @default.
- W2004994018 cites W1964331183 @default.
- W2004994018 cites W1968463041 @default.
- W2004994018 cites W1976281420 @default.
- W2004994018 cites W1988569144 @default.
- W2004994018 cites W1991136318 @default.
- W2004994018 cites W2003461797 @default.
- W2004994018 cites W2022041610 @default.
- W2004994018 cites W2030345447 @default.
- W2004994018 cites W2033342330 @default.
- W2004994018 cites W2038513777 @default.
- W2004994018 cites W2038949527 @default.
- W2004994018 cites W2060333964 @default.
- W2004994018 cites W2073431200 @default.
- W2004994018 cites W2085602910 @default.
- W2004994018 cites W2092182853 @default.
- W2004994018 doi "https://doi.org/10.3109/07435808609035448" @default.
- W2004994018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2435543" @default.
- W2004994018 hasPublicationYear "1986" @default.
- W2004994018 type Work @default.
- W2004994018 sameAs 2004994018 @default.
- W2004994018 citedByCount "13" @default.
- W2004994018 crossrefType "journal-article" @default.
- W2004994018 hasAuthorship W2004994018A5002254138 @default.
- W2004994018 hasAuthorship W2004994018A5038079945 @default.
- W2004994018 hasAuthorship W2004994018A5048869732 @default.
- W2004994018 hasAuthorship W2004994018A5071796896 @default.
- W2004994018 hasAuthorship W2004994018A5090268027 @default.
- W2004994018 hasConcept C104317684 @default.
- W2004994018 hasConcept C105580179 @default.
- W2004994018 hasConcept C143065580 @default.
- W2004994018 hasConcept C150194340 @default.
- W2004994018 hasConcept C153911025 @default.
- W2004994018 hasConcept C54009773 @default.
- W2004994018 hasConcept C54355233 @default.
- W2004994018 hasConcept C86803240 @default.
- W2004994018 hasConcept C91779695 @default.
- W2004994018 hasConceptScore W2004994018C104317684 @default.
- W2004994018 hasConceptScore W2004994018C105580179 @default.
- W2004994018 hasConceptScore W2004994018C143065580 @default.
- W2004994018 hasConceptScore W2004994018C150194340 @default.
- W2004994018 hasConceptScore W2004994018C153911025 @default.
- W2004994018 hasConceptScore W2004994018C54009773 @default.
- W2004994018 hasConceptScore W2004994018C54355233 @default.
- W2004994018 hasConceptScore W2004994018C86803240 @default.
- W2004994018 hasConceptScore W2004994018C91779695 @default.
- W2004994018 hasLocation W20049940181 @default.
- W2004994018 hasLocation W20049940182 @default.
- W2004994018 hasOpenAccess W2004994018 @default.
- W2004994018 hasPrimaryLocation W20049940181 @default.
- W2004994018 hasRelatedWork W1865915409 @default.
- W2004994018 hasRelatedWork W1976731363 @default.
- W2004994018 hasRelatedWork W2009464217 @default.
- W2004994018 hasRelatedWork W2009966535 @default.
- W2004994018 hasRelatedWork W2350324307 @default.
- W2004994018 hasRelatedWork W2367199598 @default.
- W2004994018 hasRelatedWork W2386230503 @default.
- W2004994018 hasRelatedWork W2387013357 @default.
- W2004994018 hasRelatedWork W2424525284 @default.
- W2004994018 hasRelatedWork W3030472574 @default.
- W2004994018 isParatext "false" @default.
- W2004994018 isRetracted "false" @default.
- W2004994018 magId "2004994018" @default.
- W2004994018 workType "article" @default.