Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004996851> ?p ?o ?g. }
- W2004996851 endingPage "1066" @default.
- W2004996851 startingPage "1059" @default.
- W2004996851 abstract "Site-specific DNA recombination is important for basic cellular functions including viral integration, control of gene expression, production of genetic diversity and segregation of newly replicated chromosomes, and is used by bacteriophage λ to integrate or excise its genome into and out of the host chromosome. λ recombination is carried out by the bacteriophage-encoded integrase protein (λ-int) together with accessory DNA sites and associated bending proteins that allow regulation in response to cell physiology. Here we report the crystal structures of λ-int in higher-order complexes with substrates and regulatory DNAs representing different intermediates along the reaction pathway. The structures show how the simultaneous binding of two separate domains of λ-int to DNA facilitates synapsis and can specify the order of DNA strand cleavage and exchange. An intertwined layer of amino-terminal domains bound to accessory (arm) DNAs shapes the recombination complex in a way that suggests how arm binding shifts the reaction equilibrium in favour of recombinant products." @default.
- W2004996851 created "2016-06-24" @default.
- W2004996851 creator A5036055279 @default.
- W2004996851 creator A5046884579 @default.
- W2004996851 creator A5056306966 @default.
- W2004996851 creator A5056530950 @default.
- W2004996851 creator A5056554657 @default.
- W2004996851 creator A5073115671 @default.
- W2004996851 date "2005-06-01" @default.
- W2004996851 modified "2023-10-09" @default.
- W2004996851 title "A structural basis for allosteric control of DNA recombination by λ integrase" @default.
- W2004996851 cites W11510883 @default.
- W2004996851 cites W1539796472 @default.
- W2004996851 cites W1590546489 @default.
- W2004996851 cites W1591680814 @default.
- W2004996851 cites W1834454705 @default.
- W2004996851 cites W1967071624 @default.
- W2004996851 cites W1970061155 @default.
- W2004996851 cites W1970258574 @default.
- W2004996851 cites W1973761362 @default.
- W2004996851 cites W1973763076 @default.
- W2004996851 cites W1981158669 @default.
- W2004996851 cites W1995017064 @default.
- W2004996851 cites W2000491222 @default.
- W2004996851 cites W2001641653 @default.
- W2004996851 cites W2004429664 @default.
- W2004996851 cites W2006444555 @default.
- W2004996851 cites W2006922922 @default.
- W2004996851 cites W2007678783 @default.
- W2004996851 cites W2008760320 @default.
- W2004996851 cites W2009005740 @default.
- W2004996851 cites W2013083986 @default.
- W2004996851 cites W2023054266 @default.
- W2004996851 cites W2029525578 @default.
- W2004996851 cites W2052221476 @default.
- W2004996851 cites W2059541577 @default.
- W2004996851 cites W2060061851 @default.
- W2004996851 cites W2060173479 @default.
- W2004996851 cites W2063154082 @default.
- W2004996851 cites W2065859262 @default.
- W2004996851 cites W2068514032 @default.
- W2004996851 cites W2069017620 @default.
- W2004996851 cites W2081828608 @default.
- W2004996851 cites W2083301155 @default.
- W2004996851 cites W2084319785 @default.
- W2004996851 cites W2091859537 @default.
- W2004996851 cites W2093418387 @default.
- W2004996851 cites W2094626148 @default.
- W2004996851 cites W2104975387 @default.
- W2004996851 cites W2114155688 @default.
- W2004996851 cites W2120412445 @default.
- W2004996851 cites W2128745387 @default.
- W2004996851 cites W2132422309 @default.
- W2004996851 cites W2151351143 @default.
- W2004996851 cites W2414099401 @default.
- W2004996851 cites W244067956 @default.
- W2004996851 cites W844312963 @default.
- W2004996851 cites W2144391561 @default.
- W2004996851 doi "https://doi.org/10.1038/nature03657" @default.
- W2004996851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1809751" @default.
- W2004996851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15973401" @default.
- W2004996851 hasPublicationYear "2005" @default.
- W2004996851 type Work @default.
- W2004996851 sameAs 2004996851 @default.
- W2004996851 citedByCount "160" @default.
- W2004996851 countsByYear W20049968512012 @default.
- W2004996851 countsByYear W20049968512013 @default.
- W2004996851 countsByYear W20049968512014 @default.
- W2004996851 countsByYear W20049968512015 @default.
- W2004996851 countsByYear W20049968512016 @default.
- W2004996851 countsByYear W20049968512017 @default.
- W2004996851 countsByYear W20049968512018 @default.
- W2004996851 countsByYear W20049968512019 @default.
- W2004996851 countsByYear W20049968512020 @default.
- W2004996851 countsByYear W20049968512021 @default.
- W2004996851 countsByYear W20049968512022 @default.
- W2004996851 countsByYear W20049968512023 @default.
- W2004996851 crossrefType "journal-article" @default.
- W2004996851 hasAuthorship W2004996851A5036055279 @default.
- W2004996851 hasAuthorship W2004996851A5046884579 @default.
- W2004996851 hasAuthorship W2004996851A5056306966 @default.
- W2004996851 hasAuthorship W2004996851A5056530950 @default.
- W2004996851 hasAuthorship W2004996851A5056554657 @default.
- W2004996851 hasAuthorship W2004996851A5073115671 @default.
- W2004996851 hasBestOaLocation W20049968513 @default.
- W2004996851 hasConcept C102414288 @default.
- W2004996851 hasConcept C104317684 @default.
- W2004996851 hasConcept C119898374 @default.
- W2004996851 hasConcept C14430832 @default.
- W2004996851 hasConcept C150194340 @default.
- W2004996851 hasConcept C156695909 @default.
- W2004996851 hasConcept C166342909 @default.
- W2004996851 hasConcept C170493617 @default.
- W2004996851 hasConcept C19924922 @default.
- W2004996851 hasConcept C201437064 @default.
- W2004996851 hasConcept C203284983 @default.
- W2004996851 hasConcept C2909909245 @default.
- W2004996851 hasConcept C54355233 @default.