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- W2005004525 abstract "A practical method for the conversion of tetrahydrothebaine to dihydromorphine in 92% yield is described. The procedure should allow more efficient production of opium products and may be easily modified for large-scale synthesis. The conversion of codeine to (8S)-8-bromomorphide, a potentially valuable intermediate to 6-demethoxyoripavine and derivatives, is also described. The absolute configuration of (8S)-8-bromomorphide was determined by a single-crystal X-ray diffraction study of the hydrobromide salt." @default.
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- W2005004525 date "2003-01-30" @default.
- W2005004525 modified "2023-09-25" @default.
- W2005004525 title "Practical and High-Yield Syntheses of Dihydromorphine from Tetrahydrothebaine and Efficient Syntheses of (8S)-8-Bromomorphide" @default.
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- W2005004525 doi "https://doi.org/10.1021/jo0206871" @default.
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