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- W2005005469 endingPage "e168" @default.
- W2005005469 startingPage "e168" @default.
- W2005005469 abstract "Bordetella are Gram negative bacteria that cause respiratory tract infections in humans and animals. While at least five different species of Bordetella are known to exist, this review focuses on B. pertussis, B. bronchiseptica and B. parapertussis subspecies. In their virulent phase, all of these bacteria produce a nearly identical set of virulence factors which include adhesins such as filamentous hemagglutinin (FHA), fimbriae and pertactin, as well as toxins such as a bifunctional adenylate cyclase/hemolysin, dermonecrotic toxin, tracheal cytotoxin, a B. pertussis specific pertussis toxin and B. bronchiseptica specific type III secreted proteins. Expression of nearly all of these virulence factors is positively regulated by the products of the bvgAS locus. BvgA and BvgS comprise a two-component signal transduction system that mediates transition between at least three identifiable phases---a virulent (Bvg+) phase, an avirulent (Bvg-) phase and an intermediate (Bvg(i)) phase---in response to specific environmental signals. Bordetella colonize the ciliated respiratory mucosa, a surface designed to eliminate foreign particles, thereby making the adherence and persistence mechanisms of these bacteria crucial. The development of relevant animal models for B. bronchiseptica has enabled us to study Bordetella pathogenesis in the context of natural host-pathogen interactions. In addition, evolutionary studies across the various Bordetella species and detailed analysis of differential regulation of Bvg-activated/repressed genes has greatly enhanced our understanding of the mechanisms of Bordetella pathogenesis." @default.
- W2005005469 created "2016-06-24" @default.
- W2005005469 creator A5005953351 @default.
- W2005005469 creator A5027304634 @default.
- W2005005469 creator A5054012693 @default.
- W2005005469 creator A5079743912 @default.
- W2005005469 date "2001-01-01" @default.
- W2005005469 modified "2023-10-16" @default.
- W2005005469 title "Mechanisms of bordetella pathogenesis" @default.
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