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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005012370> ?p ?o ?g. }

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• W2005012370 abstract "Le mécanisme de la résistance à la tétracycline a été étudié dans des souches de B. subtilis portant ou non le plasmide pT 127. Il est montré que la résistance peut être augmentée dans les deux types de souches par préincubation avec des concentrations non-inhibitrices de tétracycline. Aucune modification de l'activité des ribosomes, aucune inactivation intracellulaire de l'antibiotique n'ont été mises en évidence dans les deux souches étudiées. L'accumulation de tétracycline radioactive est particulièrement faible dans la souche sauvage de B. subtilis, les facteurs de concentration n'excédant pas deux à trois. Les cinétiques obtenues semblent indiquer que la perméation de la tétracycline ne correspond pas à un phénomène de transport actif chez B. subtilis. Une relation étroite a été établie entre le niveau de résistance obtenu par induction ou par la présence du plasmide pT 127, et la diminution de la perméation de l'antibiotique. The nature of tetracycline resistance was studied in a strain of Bacillus subtilis carrying the plasmid pT 127 in comparison with the parental strain. The resistance has been shown to be inducible in both strains upon exposure to subinhibitory concentrations of tetracycline. No modification of the protein-synthesizing activity of the ribosomes or intracellular inactivation of the antibiotic was observed in both strains. Accumulation of labeled tetracycline in B. subtilis was found to be particularly low in the wild-type strain, compared to other bacterial species, with concentration gradients of only 2 to 3 fold. From the kinetics obtained it is likely that the permeation of the antibiotic does not correspond to an active process in B. subtilis. A fairly good correlation was established between the level of resistance obtained after induction or by the presence of the plasmid pT 127 and a decrease in the binding capacity of the cell for the antibiotic." @default.
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• W2005012370 title "On the nature of tetracycline resistance in Bacillus subtilis mediated by the plasmid pT 127" @default.
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• W2005012370 doi "https://doi.org/10.1016/s0300-9084(79)80317-x" @default.
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