FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005013854> ?p ?o ?g. }

• W2005013854 endingPage "2497" @default.
• W2005013854 startingPage "2489" @default.
• W2005013854 abstract "We report on the development of a novel biodegradable scaffold capable of enhancing mechanical signals for tissue-engineering applications. It has been shown that mechanotransduction enhances bone formation in vitro and in vivo; in tissue-engineering applications, this phenomenon is exploited through the use of mechanical bioreactors to generate bone tissue. The dihydropyridine agonist Bay K8644 (Bay) acts to increase the opening time of mechanosensitive voltage-operated calcium channels (VOCCs), specifi- cally L-type VOCCs, which are known to play a fundamental role in the early mediation of mechanotransduction. We have produced porous 3-dimensional, Bay-encapsulated biodegradable poly(L-lactide) acid scaffolds using a solvent-casting and salt-leaching technique. The effects of the released Bay on osteoid production and mineralization in human bone cell-seeded constructs following incubation in a perfusion-compression bioreactor in vitro was investigated using Western blotting techniques and a calcium assay protocol developed in our lab. Our newly developed scaffolds act by slowly releasing the calcium channel agonist Bay K8644 as observed using ultraviolet spectroscopy, maintaining the open state of mechanosensitive VOCCs responding to load, which augments the load signal at sites of strain across the scaffold. Our results demonstrate that, in the presence of physiological loading regimes in vitro, release of Bay enhances collagen I protein production and osteoid calcification more than non-Bay control constructs do. Osteopontin and alpha2delta1 VOCC subunit protein levels were also higher as a result of perfusion-compression conditioning. These results indicate that Bay-encapsulated scaffolds can be used in the presence of load to enhance the production of load-bearing engineered tissue." @default.
• W2005013854 created "2016-06-24" @default.
• W2005013854 creator A5015269070 @default.
• W2005013854 creator A5016976971 @default.
• W2005013854 creator A5021333955 @default.
• W2005013854 creator A5051776480 @default.
• W2005013854 date "2006-09-01" @default.
• W2005013854 modified "2023-09-26" @default.
• W2005013854 title "Using Dihydropyridine-Release Strategies to Enhance Load Effects in Engineered Human Bone Constructs" @default.
• W2005013854 cites W1574631190 @default.
• W2005013854 cites W1626382598 @default.
• W2005013854 cites W1965676278 @default.
• W2005013854 cites W1966262538 @default.
• W2005013854 cites W1966723290 @default.
• W2005013854 cites W1978200136 @default.
• W2005013854 cites W1979030140 @default.
• W2005013854 cites W1993180064 @default.
• W2005013854 cites W1999503127 @default.
• W2005013854 cites W1999568615 @default.
• W2005013854 cites W2001496248 @default.
• W2005013854 cites W2007622582 @default.
• W2005013854 cites W2009775448 @default.
• W2005013854 cites W2012821794 @default.
• W2005013854 cites W2024621576 @default.
• W2005013854 cites W2058334050 @default.
• W2005013854 cites W2070213849 @default.
• W2005013854 cites W2091403755 @default.
• W2005013854 cites W2094560262 @default.
• W2005013854 cites W2111441888 @default.
• W2005013854 cites W2131978756 @default.
• W2005013854 cites W2139457077 @default.
• W2005013854 cites W2152840072 @default.
• W2005013854 cites W2163895773 @default.
• W2005013854 cites W2172914696 @default.
• W2005013854 cites W2225305232 @default.
• W2005013854 cites W2334636097 @default.
• W2005013854 cites W2410251526 @default.
• W2005013854 cites W4232263194 @default.
• W2005013854 doi "https://doi.org/10.1089/ten.2006.12.2489" @default.
• W2005013854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16995782" @default.
• W2005013854 hasPublicationYear "2006" @default.
• W2005013854 type Work @default.
• W2005013854 sameAs 2005013854 @default.
• W2005013854 citedByCount "26" @default.
• W2005013854 countsByYear W20050138542014 @default.
• W2005013854 countsByYear W20050138542015 @default.
• W2005013854 countsByYear W20050138542021 @default.
• W2005013854 countsByYear W20050138542023 @default.
• W2005013854 crossrefType "journal-article" @default.
• W2005013854 hasAuthorship W2005013854A5015269070 @default.
• W2005013854 hasAuthorship W2005013854A5016976971 @default.
• W2005013854 hasAuthorship W2005013854A5021333955 @default.
• W2005013854 hasAuthorship W2005013854A5051776480 @default.
• W2005013854 hasConcept C105702510 @default.
• W2005013854 hasConcept C12554922 @default.
• W2005013854 hasConcept C136229726 @default.
• W2005013854 hasConcept C170493617 @default.
• W2005013854 hasConcept C178790620 @default.
• W2005013854 hasConcept C17938293 @default.
• W2005013854 hasConcept C181104049 @default.
• W2005013854 hasConcept C185592680 @default.
• W2005013854 hasConcept C2780550940 @default.
• W2005013854 hasConcept C2781212610 @default.
• W2005013854 hasConcept C2781391105 @default.
• W2005013854 hasConcept C4001165 @default.
• W2005013854 hasConcept C49892992 @default.
• W2005013854 hasConcept C50254741 @default.
• W2005013854 hasConcept C519063684 @default.
• W2005013854 hasConcept C55493867 @default.
• W2005013854 hasConcept C71924100 @default.
• W2005013854 hasConcept C86803240 @default.
• W2005013854 hasConcept C95444343 @default.
• W2005013854 hasConceptScore W2005013854C105702510 @default.
• W2005013854 hasConceptScore W2005013854C12554922 @default.
• W2005013854 hasConceptScore W2005013854C136229726 @default.
• W2005013854 hasConceptScore W2005013854C170493617 @default.
• W2005013854 hasConceptScore W2005013854C178790620 @default.
• W2005013854 hasConceptScore W2005013854C17938293 @default.
• W2005013854 hasConceptScore W2005013854C181104049 @default.
• W2005013854 hasConceptScore W2005013854C185592680 @default.
• W2005013854 hasConceptScore W2005013854C2780550940 @default.
• W2005013854 hasConceptScore W2005013854C2781212610 @default.
• W2005013854 hasConceptScore W2005013854C2781391105 @default.
• W2005013854 hasConceptScore W2005013854C4001165 @default.
• W2005013854 hasConceptScore W2005013854C49892992 @default.
• W2005013854 hasConceptScore W2005013854C50254741 @default.
• W2005013854 hasConceptScore W2005013854C519063684 @default.
• W2005013854 hasConceptScore W2005013854C55493867 @default.
• W2005013854 hasConceptScore W2005013854C71924100 @default.
• W2005013854 hasConceptScore W2005013854C86803240 @default.
• W2005013854 hasConceptScore W2005013854C95444343 @default.
• W2005013854 hasIssue "9" @default.
• W2005013854 hasLocation W20050138541 @default.
• W2005013854 hasLocation W20050138542 @default.
• W2005013854 hasOpenAccess W2005013854 @default.
• W2005013854 hasPrimaryLocation W20050138541 @default.
• W2005013854 hasRelatedWork W1768125372 @default.
• W2005013854 hasRelatedWork W187084099 @default.

• next