Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005013872> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W2005013872 abstract "The last decade has witnessed a revolution in pharmaceutical sciences and commercial products with the introduction and intensification of biological products. Foremost has been the development and commercialization of antibodies, particularly for the therapy of cancer, with 8 such products already approved in the USA and hundreds of product candidates in various stages of clinical development. Although monoclonal antibodies have been pursued as new commercial candidates for about 30 years, advances in antibody engineering were required to de-immunize them for repeated human use, and when used as targeting agents, various constructs with isotopes, drug, and toxins have been developed and commercialized. As new targets become identified, the diverse antibody products are gaining in attention as prospective new therapeutics even beyond cancer, such as in the therapy of autoimmune, infectious, and neurodegenerative diseases. Not only are new antibody constructs of multifunctional nature being developed for enhanced potency, but new delivery systems involving methods of separating the targeting moiety from the effector molecules (radionuclided, drugs, toxins, cytokines), such as in so-called pretargeting methods, are under development. These advances have resulted in the concept of targeted disease therapy, attended by a better safety profile for this new class of pharmaceuticals, and are being used increasingly in combination with conventional cytotoxic drugs approved for the therapy of cancer and immune diseases. These disease-targeting antibodies, however, should soon decrease the dependence on traditional cytotoxic drugs by targeting such agents more selectively as immunoconjugates, especially with pretargeting technologies." @default.
- W2005013872 created "2016-06-24" @default.
- W2005013872 creator A5003890903 @default.
- W2005013872 date "2006-08-01" @default.
- W2005013872 modified "2023-09-26" @default.
- W2005013872 title "Targeted Therapy with Monoclonal Antibodies: The New Generation of Pharmaceuticals" @default.
- W2005013872 doi "https://doi.org/10.1109/iembs.2006.259776" @default.
- W2005013872 hasPublicationYear "2006" @default.
- W2005013872 type Work @default.
- W2005013872 sameAs 2005013872 @default.
- W2005013872 citedByCount "0" @default.
- W2005013872 crossrefType "proceedings-article" @default.
- W2005013872 hasAuthorship W2005013872A5003890903 @default.
- W2005013872 hasConcept C121608353 @default.
- W2005013872 hasConcept C126322002 @default.
- W2005013872 hasConcept C159654299 @default.
- W2005013872 hasConcept C203014093 @default.
- W2005013872 hasConcept C2776146153 @default.
- W2005013872 hasConcept C2777836882 @default.
- W2005013872 hasConcept C2781230642 @default.
- W2005013872 hasConcept C3020495827 @default.
- W2005013872 hasConcept C542903549 @default.
- W2005013872 hasConcept C71924100 @default.
- W2005013872 hasConceptScore W2005013872C121608353 @default.
- W2005013872 hasConceptScore W2005013872C126322002 @default.
- W2005013872 hasConceptScore W2005013872C159654299 @default.
- W2005013872 hasConceptScore W2005013872C203014093 @default.
- W2005013872 hasConceptScore W2005013872C2776146153 @default.
- W2005013872 hasConceptScore W2005013872C2777836882 @default.
- W2005013872 hasConceptScore W2005013872C2781230642 @default.
- W2005013872 hasConceptScore W2005013872C3020495827 @default.
- W2005013872 hasConceptScore W2005013872C542903549 @default.
- W2005013872 hasConceptScore W2005013872C71924100 @default.
- W2005013872 hasLocation W20050138721 @default.
- W2005013872 hasOpenAccess W2005013872 @default.
- W2005013872 hasPrimaryLocation W20050138721 @default.
- W2005013872 hasRelatedWork W1972807710 @default.
- W2005013872 hasRelatedWork W1990314683 @default.
- W2005013872 hasRelatedWork W199168801 @default.
- W2005013872 hasRelatedWork W2122584026 @default.
- W2005013872 hasRelatedWork W2310957749 @default.
- W2005013872 hasRelatedWork W2363885141 @default.
- W2005013872 hasRelatedWork W2371164331 @default.
- W2005013872 hasRelatedWork W2422675208 @default.
- W2005013872 hasRelatedWork W2773325876 @default.
- W2005013872 hasRelatedWork W2794384489 @default.
- W2005013872 isParatext "false" @default.
- W2005013872 isRetracted "false" @default.
- W2005013872 magId "2005013872" @default.
- W2005013872 workType "article" @default.