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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005015636> ?p ?o ?g. }

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• W2005015636 abstract "We identified a series of 4-hydroxyquinolines bearing a C1 to C15 alkyl chain at the C2 position and a carbethoxy/carboxy group at the C3 position of the quinoline nucleus (MC compounds), endowed with selective inhibitory activity against the p300/CBP HAT enzymes. Enzyme inhibition was investigated using in vitro HAT assays and by western blot analysis of cellular lysates to examine the acetylation levels of histone H3 and α-tubulin. When tested in U937 cells, some compounds displayed pro-apoptotic or cytodifferentiating properties." @default.
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• W2005015636 date "2009-02-01" @default.
• W2005015636 modified "2023-09-27" @default.
• W2005015636 title "Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases" @default.
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• W2005015636 doi "https://doi.org/10.1016/j.bmcl.2008.12.097" @default.
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