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- W2005016571 abstract "Purpose of review Pigs have emerged as potential sources of islets for clinical transplantation. Wild-type porcine islets (adult and neonatal) transplanted into the portal vein have successfully reversed diabetes in nonhuman primates. However, there is a rapid loss of the transplanted islets on exposure to blood, known as the instant blood-mediated inflammatory reaction (IBMIR), as well as a T-cell response that leads to rejection of the graft. Recent findings Genetically modified pig islets offer a number of potential advantages, particularly with regard to reducing the IBMIR-related graft loss and protecting the islets from the primate immune response. Emerging data indicate that transgenes specifically targeted to pig β cells using an insulin promoter (in order to maximize target tissue expression while limiting host effects) can be achieved without significant effects on the pig's glucose metabolism. Summary Experience with the transplantation of islets from genetically engineered pigs into nonhuman primates is steadily increasing, and has involved the deletion of pig antigenic targets to reduce the primate humoral response, the expression of transgenes for human complement-regulatory and coagulation-regulatory proteins, and manipulations to reduce the effect of the T-cell response. There is increasing evidence of the advantages of using genetically engineered pigs as sources of islets for future clinical trials." @default.
- W2005016571 created "2016-06-24" @default.
- W2005016571 creator A5017682705 @default.
- W2005016571 creator A5021163102 @default.
- W2005016571 creator A5042071873 @default.
- W2005016571 creator A5053200897 @default.
- W2005016571 creator A5081922442 @default.
- W2005016571 creator A5085492854 @default.
- W2005016571 date "2013-12-01" @default.
- W2005016571 modified "2023-09-23" @default.
- W2005016571 title "Islet xenotransplantation from genetically engineered pigs" @default.
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