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- W2005016581 abstract "Estrogens have direct effects on the brain areas controlling cognition. One of the most studied of these regions is the dorsal hippocampal formation, which governs the formation of spatial and episodic memories. In laboratory animals, most investigators report that estrogen enhances synaptic plasticity and improves performance on hippocampal-dependent cognitive behaviors. This review summarizes work conducted in our laboratory and others toward identifying estrogen’s actions in the hippocampal formation, and the mechanisms for these actions. Physiologic and pharmacologic estrogen affects cognitive behavior in mammals, which may be applicable to human health and disease. The effects of estrogen in the hippocampal formation that lead to modulation of hippocampal function include effects on cell morphology, synapse formation, signaling, and excitability that have been studied in laboratory mice, rats, and primates. Finally, estrogen may signal through both nuclear and extranuclear hippocampal estrogen receptors to achieve its downstream effects." @default.
- W2005016581 created "2016-06-24" @default.
- W2005016581 creator A5004990772 @default.
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- W2005016581 creator A5034406998 @default.
- W2005016581 creator A5035103174 @default.
- W2005016581 creator A5087864446 @default.
- W2005016581 date "2008-05-01" @default.
- W2005016581 modified "2023-10-05" @default.
- W2005016581 title "Uncovering the mechanisms of estrogen effects on hippocampal function" @default.
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