FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005016840> ?p ?o ?g. }

• W2005016840 endingPage "1147" @default.
• W2005016840 startingPage "1135" @default.
• W2005016840 abstract "Background: Cart1 encodes the paired-like homeodomain in the central portion of the gene, and plays a crucial role in the developmental lineage of bone and cartilage, especially in head formation. However, its transactivation mechanism is still poorly understood, including the target gene. Here, we report biochemical dissections of Cart1 functional domains and a relationship between dimerization and transcription activity. Results: Deletion studies of GAL4-fused Cart1 indicated that the transactivation domain is located in the middle portion of the C-terminal domain, but the N-terminal is also required for a full activation of the consensus palindromic binding site (TAATNNNATTA). Analysis of the basic amino acid residues at both ends of the homeodomain revealed that both sides act as nuclear localization signals, and are necessary for the cooperative binding to the palindromic sequence. In this study, two additional Cart1 isoforms that behave as dominant negatives were identified from rat chondrosarcoma cells. These isoforms suppressed the transcription activity of the wild-type, despite loss of DNA binding ability, and could interact with the wild-type in yeast. Finally, we demonstrated that wild-type Cart1 forms a DNA-independent homodimer in in vivo conditions, and that the transactivation of wild-type Cart1 was suppressed by the N- or C-terminal domain which was expressed in the nucleus. Conclusion: These results revealed that homodimerization through direct interaction is necessary for the potent transcription activity of Cart1." @default.
• W2005016840 created "2016-06-24" @default.
• W2005016840 creator A5000823812 @default.
• W2005016840 creator A5011248050 @default.
• W2005016840 creator A5017570111 @default.
• W2005016840 creator A5047776373 @default.
• W2005016840 creator A5049808190 @default.
• W2005016840 creator A5055846880 @default.
• W2005016840 creator A5078666381 @default.
• W2005016840 creator A5085279080 @default.
• W2005016840 date "2002-10-17" @default.
• W2005016840 modified "2023-10-11" @default.
• W2005016840 title "Functional domains of paired-like homeoprotein Cart1 and the relationship between dimerization and transcription activity" @default.
• W2005016840 cites W1565800544 @default.
• W2005016840 cites W1971495210 @default.
• W2005016840 cites W197372360 @default.
• W2005016840 cites W1975244118 @default.
• W2005016840 cites W1990230630 @default.
• W2005016840 cites W1998013410 @default.
• W2005016840 cites W2001089439 @default.
• W2005016840 cites W2003016051 @default.
• W2005016840 cites W2006990136 @default.
• W2005016840 cites W2014104304 @default.
• W2005016840 cites W2015448530 @default.
• W2005016840 cites W2022571490 @default.
• W2005016840 cites W2030487990 @default.
• W2005016840 cites W2032316637 @default.
• W2005016840 cites W2034597965 @default.
• W2005016840 cites W2045594625 @default.
• W2005016840 cites W2047956044 @default.
• W2005016840 cites W2052839126 @default.
• W2005016840 cites W2060484473 @default.
• W2005016840 cites W2075447762 @default.
• W2005016840 cites W2076849893 @default.
• W2005016840 cites W2081597769 @default.
• W2005016840 cites W2094298080 @default.
• W2005016840 cites W2109433965 @default.
• W2005016840 cites W2121475173 @default.
• W2005016840 cites W2131011930 @default.
• W2005016840 cites W2136190597 @default.
• W2005016840 cites W2139310783 @default.
• W2005016840 cites W2141108470 @default.
• W2005016840 cites W2148677963 @default.
• W2005016840 cites W2152134406 @default.
• W2005016840 cites W2155015939 @default.
• W2005016840 cites W2158896330 @default.
• W2005016840 cites W2186560096 @default.
• W2005016840 cites W4254829742 @default.
• W2005016840 doi "https://doi.org/10.1046/j.1365-2443.2002.00587.x" @default.
• W2005016840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12390248" @default.
• W2005016840 hasPublicationYear "2002" @default.
• W2005016840 type Work @default.
• W2005016840 sameAs 2005016840 @default.
• W2005016840 citedByCount "22" @default.
• W2005016840 countsByYear W20050168402012 @default.
• W2005016840 countsByYear W20050168402014 @default.
• W2005016840 countsByYear W20050168402015 @default.
• W2005016840 countsByYear W20050168402016 @default.
• W2005016840 countsByYear W20050168402020 @default.
• W2005016840 countsByYear W20050168402021 @default.
• W2005016840 crossrefType "journal-article" @default.
• W2005016840 hasAuthorship W2005016840A5000823812 @default.
• W2005016840 hasAuthorship W2005016840A5011248050 @default.
• W2005016840 hasAuthorship W2005016840A5017570111 @default.
• W2005016840 hasAuthorship W2005016840A5047776373 @default.
• W2005016840 hasAuthorship W2005016840A5049808190 @default.
• W2005016840 hasAuthorship W2005016840A5055846880 @default.
• W2005016840 hasAuthorship W2005016840A5078666381 @default.
• W2005016840 hasAuthorship W2005016840A5085279080 @default.
• W2005016840 hasBestOaLocation W20050168401 @default.
• W2005016840 hasConcept C104317684 @default.
• W2005016840 hasConcept C121587040 @default.
• W2005016840 hasConcept C1292079 @default.
• W2005016840 hasConcept C138885662 @default.
• W2005016840 hasConcept C179926584 @default.
• W2005016840 hasConcept C41895202 @default.
• W2005016840 hasConcept C44667518 @default.
• W2005016840 hasConcept C53345823 @default.
• W2005016840 hasConcept C54355233 @default.
• W2005016840 hasConcept C552990157 @default.
• W2005016840 hasConcept C76557 @default.
• W2005016840 hasConcept C86339819 @default.
• W2005016840 hasConcept C86803240 @default.
• W2005016840 hasConcept C95444343 @default.
• W2005016840 hasConcept C98108389 @default.
• W2005016840 hasConceptScore W2005016840C104317684 @default.
• W2005016840 hasConceptScore W2005016840C121587040 @default.
• W2005016840 hasConceptScore W2005016840C1292079 @default.
• W2005016840 hasConceptScore W2005016840C138885662 @default.
• W2005016840 hasConceptScore W2005016840C179926584 @default.
• W2005016840 hasConceptScore W2005016840C41895202 @default.
• W2005016840 hasConceptScore W2005016840C44667518 @default.
• W2005016840 hasConceptScore W2005016840C53345823 @default.
• W2005016840 hasConceptScore W2005016840C54355233 @default.
• W2005016840 hasConceptScore W2005016840C552990157 @default.
• W2005016840 hasConceptScore W2005016840C76557 @default.
• W2005016840 hasConceptScore W2005016840C86339819 @default.
• W2005016840 hasConceptScore W2005016840C86803240 @default.

• next