Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005016962> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2005016962 endingPage "PL91" @default.
- W2005016962 startingPage "PL87" @default.
- W2005016962 abstract "Previously, we have shown that subcutaneous administration of insulin stimulates ornithine decarboxylase (ODC) mRNA expression and enzymatic activity in the liver of infant control rats, but not in those pretreated intracerebroventricularly (i.c.v.) with beta-endorphin. This finding is consistent with the hypothesis that beta-endorphin synthesized in the brain plays a prime role in the control of postnatal development, in part, by modulating ODC gene transcription. We now report that insulin induced stimulation of hepatic ODC mRNA expression is accompanied by a concomitant increase in the expression of c-myc and max mRNAs, and that this effect is also inhibited by pretreatment with i.c.v. beta-endorphin. These results suggest that CNS beta-endorphin suppresses tissue ODC responsiveness to trophic hormones by downregulating the expression of c-myc and max mRNAs, the encoded proteins of which are known to act physiologically as transcriptional activators of the ODC gene." @default.
- W2005016962 created "2016-06-24" @default.
- W2005016962 creator A5000479309 @default.
- W2005016962 creator A5005721204 @default.
- W2005016962 creator A5017959102 @default.
- W2005016962 creator A5074811994 @default.
- W2005016962 date "1998-12-01" @default.
- W2005016962 modified "2023-09-26" @default.
- W2005016962 title "Involvement of c-myc and max in CNS β-endorphin modulation of hepatic ornithine decarboxylase responsiveness to insulin in rat pups" @default.
- W2005016962 cites W1567178433 @default.
- W2005016962 cites W1584373876 @default.
- W2005016962 cites W1972402664 @default.
- W2005016962 cites W1989009382 @default.
- W2005016962 cites W1999828574 @default.
- W2005016962 cites W2005165314 @default.
- W2005016962 cites W2019489475 @default.
- W2005016962 cites W2021182851 @default.
- W2005016962 cites W2044499033 @default.
- W2005016962 cites W2054758465 @default.
- W2005016962 cites W2096462919 @default.
- W2005016962 cites W2112535186 @default.
- W2005016962 cites W2157874460 @default.
- W2005016962 cites W2281124822 @default.
- W2005016962 cites W4236512674 @default.
- W2005016962 cites W4236735908 @default.
- W2005016962 cites W4238270754 @default.
- W2005016962 cites W4242691368 @default.
- W2005016962 doi "https://doi.org/10.1016/s0024-3205(98)00572-4" @default.
- W2005016962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10072196" @default.
- W2005016962 hasPublicationYear "1998" @default.
- W2005016962 type Work @default.
- W2005016962 sameAs 2005016962 @default.
- W2005016962 citedByCount "2" @default.
- W2005016962 crossrefType "journal-article" @default.
- W2005016962 hasAuthorship W2005016962A5000479309 @default.
- W2005016962 hasAuthorship W2005016962A5005721204 @default.
- W2005016962 hasAuthorship W2005016962A5017959102 @default.
- W2005016962 hasAuthorship W2005016962A5074811994 @default.
- W2005016962 hasConcept C104317684 @default.
- W2005016962 hasConcept C105580179 @default.
- W2005016962 hasConcept C108905728 @default.
- W2005016962 hasConcept C121289238 @default.
- W2005016962 hasConcept C126322002 @default.
- W2005016962 hasConcept C134018914 @default.
- W2005016962 hasConcept C138885662 @default.
- W2005016962 hasConcept C150194340 @default.
- W2005016962 hasConcept C179926584 @default.
- W2005016962 hasConcept C181199279 @default.
- W2005016962 hasConcept C24998067 @default.
- W2005016962 hasConcept C2779306644 @default.
- W2005016962 hasConcept C41895202 @default.
- W2005016962 hasConcept C55493867 @default.
- W2005016962 hasConcept C71315377 @default.
- W2005016962 hasConcept C71924100 @default.
- W2005016962 hasConcept C86803240 @default.
- W2005016962 hasConceptScore W2005016962C104317684 @default.
- W2005016962 hasConceptScore W2005016962C105580179 @default.
- W2005016962 hasConceptScore W2005016962C108905728 @default.
- W2005016962 hasConceptScore W2005016962C121289238 @default.
- W2005016962 hasConceptScore W2005016962C126322002 @default.
- W2005016962 hasConceptScore W2005016962C134018914 @default.
- W2005016962 hasConceptScore W2005016962C138885662 @default.
- W2005016962 hasConceptScore W2005016962C150194340 @default.
- W2005016962 hasConceptScore W2005016962C179926584 @default.
- W2005016962 hasConceptScore W2005016962C181199279 @default.
- W2005016962 hasConceptScore W2005016962C24998067 @default.
- W2005016962 hasConceptScore W2005016962C2779306644 @default.
- W2005016962 hasConceptScore W2005016962C41895202 @default.
- W2005016962 hasConceptScore W2005016962C55493867 @default.
- W2005016962 hasConceptScore W2005016962C71315377 @default.
- W2005016962 hasConceptScore W2005016962C71924100 @default.
- W2005016962 hasConceptScore W2005016962C86803240 @default.
- W2005016962 hasIssue "5" @default.
- W2005016962 hasLocation W20050169621 @default.
- W2005016962 hasLocation W20050169622 @default.
- W2005016962 hasOpenAccess W2005016962 @default.
- W2005016962 hasPrimaryLocation W20050169621 @default.
- W2005016962 hasRelatedWork W1983641721 @default.
- W2005016962 hasRelatedWork W1995945960 @default.
- W2005016962 hasRelatedWork W2026226896 @default.
- W2005016962 hasRelatedWork W2032033851 @default.
- W2005016962 hasRelatedWork W2041678535 @default.
- W2005016962 hasRelatedWork W2058152093 @default.
- W2005016962 hasRelatedWork W2066345847 @default.
- W2005016962 hasRelatedWork W2089387278 @default.
- W2005016962 hasRelatedWork W2095179743 @default.
- W2005016962 hasRelatedWork W2130904138 @default.
- W2005016962 hasVolume "64" @default.
- W2005016962 isParatext "false" @default.
- W2005016962 isRetracted "false" @default.
- W2005016962 magId "2005016962" @default.
- W2005016962 workType "article" @default.