FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005018866> ?p ?o ?g. }

• W2005018866 endingPage "506" @default.
• W2005018866 startingPage "496" @default.
• W2005018866 abstract "Insights into mechanisms governing resolution of inflammatory pain are of great importance for many chronic pain–associated diseases. Here we investigate the role of macrophages/monocytes and the anti-inflammatory cytokine interleukin-10 (IL-10) in the resolution of transient inflammatory pain. Depletion of mice from peripheral monocytes/macrophages delayed resolution of intraplantar IL-1β- and carrageenan-induced inflammatory hyperalgesia from 1 to 3 days to >1 week. Intrathecal administration of a neutralizing IL-10 antibody also markedly delayed resolution of IL-1β- and carrageenan-induced inflammatory hyperalgesia. Recently, we showed that IL-1β- and carrageenan-induced hyperalgesia is significantly prolonged in LysM-GRK2+/− mice, which have reduced levels of G-protein-coupled receptor kinase 2 (GRK2) in LysM+ myeloid cells. Here we show that adoptive transfer of wild-type, but not of GRK2+/−, bone marrow-derived monocytes normalizes the resolution of IL-1β-induced hyperalgesia in LysM-GRK2+/− mice. Adoptive transfer of IL-10−/− bone marrow-derived monocytes failed to normalize the duration of IL-1β-induced hyperalgesia in LysM-GRK2+/− mice. Mechanistically, we show that GRK2+/− macrophages produce less IL-10 in vitro. In addition, intrathecal IL-10 administration attenuated IL-1β-induced hyperalgesia in LysM-GRK2+/− mice, whereas it had no effect in wild-type mice. Our data uncover a key role for monocytes/macrophages in promoting resolution of inflammatory hyperalgesia via a mechanism dependent on IL-10 signaling in dorsal root ganglia.PerspectiveWe show that IL-10-producing monocytes/macrophages promote resolution of transient inflammatory hyperalgesia. Additionally, we show that reduced monocyte/macrophage GRK2 impairs resolution of hyperalgesia and reduces IL-10 production. We propose that low GRK2 expression and/or impaired IL-10 production by monocytes/macrophages represent peripheral biomarkers for the risk of developing chronic pain after inflammation." @default.
• W2005018866 created "2016-06-24" @default.
• W2005018866 creator A5007674783 @default.
• W2005018866 creator A5020165463 @default.
• W2005018866 creator A5042225204 @default.
• W2005018866 creator A5042261156 @default.
• W2005018866 creator A5065208828 @default.
• W2005018866 creator A5069621745 @default.
• W2005018866 creator A5085709802 @default.
• W2005018866 creator A5089641600 @default.
• W2005018866 date "2014-05-01" @default.
• W2005018866 modified "2023-10-16" @default.
• W2005018866 title "Monocytes/Macrophages Control Resolution of Transient Inflammatory Pain" @default.
• W2005018866 cites W1550545417 @default.
• W2005018866 cites W1551715961 @default.
• W2005018866 cites W1768234879 @default.
• W2005018866 cites W1925803619 @default.
• W2005018866 cites W1964849585 @default.
• W2005018866 cites W1966842136 @default.
• W2005018866 cites W1967857969 @default.
• W2005018866 cites W1986809710 @default.
• W2005018866 cites W1993677761 @default.
• W2005018866 cites W1995503285 @default.
• W2005018866 cites W1996199386 @default.
• W2005018866 cites W2014007136 @default.
• W2005018866 cites W2018132607 @default.
• W2005018866 cites W2023952534 @default.
• W2005018866 cites W2024668472 @default.
• W2005018866 cites W2025002129 @default.
• W2005018866 cites W2026766294 @default.
• W2005018866 cites W2026808357 @default.
• W2005018866 cites W2029847351 @default.
• W2005018866 cites W2030706201 @default.
• W2005018866 cites W2030812678 @default.
• W2005018866 cites W2040299229 @default.
• W2005018866 cites W2058818446 @default.
• W2005018866 cites W2059947650 @default.
• W2005018866 cites W2061605734 @default.
• W2005018866 cites W2064462697 @default.
• W2005018866 cites W2069451135 @default.
• W2005018866 cites W2077885131 @default.
• W2005018866 cites W2084790948 @default.
• W2005018866 cites W2085052329 @default.
• W2005018866 cites W2091186496 @default.
• W2005018866 cites W2092585276 @default.
• W2005018866 cites W2124355299 @default.
• W2005018866 cites W2125558391 @default.
• W2005018866 cites W2126264913 @default.
• W2005018866 cites W2127070923 @default.
• W2005018866 cites W2127509018 @default.
• W2005018866 cites W2130529018 @default.
• W2005018866 cites W2138780833 @default.
• W2005018866 cites W2140441724 @default.
• W2005018866 cites W2163203231 @default.
• W2005018866 cites W2163825883 @default.
• W2005018866 cites W2166992424 @default.
• W2005018866 cites W2169749991 @default.
• W2005018866 cites W2169973614 @default.
• W2005018866 doi "https://doi.org/10.1016/j.jpain.2014.01.491" @default.
• W2005018866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4075647" @default.
• W2005018866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24793056" @default.
• W2005018866 hasPublicationYear "2014" @default.
• W2005018866 type Work @default.
• W2005018866 sameAs 2005018866 @default.
• W2005018866 citedByCount "79" @default.
• W2005018866 countsByYear W20050188662014 @default.
• W2005018866 countsByYear W20050188662015 @default.
• W2005018866 countsByYear W20050188662016 @default.
• W2005018866 countsByYear W20050188662017 @default.
• W2005018866 countsByYear W20050188662018 @default.
• W2005018866 countsByYear W20050188662019 @default.
• W2005018866 countsByYear W20050188662020 @default.
• W2005018866 countsByYear W20050188662021 @default.
• W2005018866 countsByYear W20050188662022 @default.
• W2005018866 countsByYear W20050188662023 @default.
• W2005018866 crossrefType "journal-article" @default.
• W2005018866 hasAuthorship W2005018866A5007674783 @default.
• W2005018866 hasAuthorship W2005018866A5020165463 @default.
• W2005018866 hasAuthorship W2005018866A5042225204 @default.
• W2005018866 hasAuthorship W2005018866A5042261156 @default.
• W2005018866 hasAuthorship W2005018866A5065208828 @default.
• W2005018866 hasAuthorship W2005018866A5069621745 @default.
• W2005018866 hasAuthorship W2005018866A5085709802 @default.
• W2005018866 hasAuthorship W2005018866A5089641600 @default.
• W2005018866 hasBestOaLocation W20050188661 @default.
• W2005018866 hasConcept C126322002 @default.
• W2005018866 hasConcept C15490471 @default.
• W2005018866 hasConcept C170493617 @default.
• W2005018866 hasConcept C203014093 @default.
• W2005018866 hasConcept C2776090121 @default.
• W2005018866 hasConcept C2776914184 @default.
• W2005018866 hasConcept C2778690821 @default.
• W2005018866 hasConcept C2779245659 @default.
• W2005018866 hasConcept C2781184567 @default.
• W2005018866 hasConcept C71924100 @default.
• W2005018866 hasConcept C8891405 @default.
• W2005018866 hasConcept C90375314 @default.
• W2005018866 hasConcept C98274493 @default.

• next