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- W2005018877 abstract "Abstract 1. 1. The control of carbohydrate metabolism in the developing mammal and the lack of certain hepatic control mechanisms prior to maturation were briefly reviewed. 2. 2. The enzymes available in the liver for the phosphorylation of glucose and fructose were summarized and the unique roles of glucokinase and fructo-kinase indicated. 3. 3. Glucokinase is absent from fetal liver and develops immediately after birth in the guinea-pig but first appears about 16 days post-parturition in the rat and reaches adult levels 10–12 days later. 4. 4. This development of glucokinase is not due to an activation process but is almost certainly de novo synthesis of new enzyme. 5. 5. Attempts to induce glucokinase development at an earlier stage had marginal effects only, and its absence from rat liver prior to the 16th day is not due to lack of insulin. 6. 6. Hydrocortisone had a small effect on advancing initiation of glucokinase appearance but did not affect the rate of apparent synthesis. 7. 7. Glucokinase synthesis was impaired when neonatal rats were starved during the developmental period. When these starved animals were refed they were able to synthesize glucokinase enabling the activities of their untreated litter-mates to be achieved quickly. Some form of development of the cell apparatus for the regulation of enzyme synthesis was continuing during the period of starvation, and possible mechanisms have been discussed. 8. 8. Fructokinase also develops after birth in both fructogenic and non-fructogenic species and this may represent another example of development of an enzyme in response to hormonal changes occurring as a result of parturition." @default.
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- W2005018877 date "1965-01-01" @default.
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- W2005018877 title "Development of hepatic enzymes for the phosphorylation of glucose and fructose" @default.
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