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- W2005019117 abstract "Photoreceptor cells utilize ribbon synapses to transmit sensory signals at high resolution. Ribbon synapses release neurotransmitters tonically, with a high release rate made possible by continuous docking of synaptic vesicles on presynaptic ribbons. We have partially purified synaptic ribbons from retina and identified a major protein component called RIBEYE. RIBEYE is composed of a unique A domain specific for ribbons, and a B domain identical with CtBP2, a transcriptional repressor that in turn is related to 2-hydroxyacid dehydrogenases. The A domain mediates assembly of RIBEYE into large structures, whereas the B domain binds NAD+ with high affinity, similar to 2-hydroxyacid dehydrogenases. Our results define a unique component of synaptic ribbons and suggest that RIBEYE evolved in vertebrates under utilization of a preexisting protein to build a unique scaffold for a specialized synapse." @default.
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- W2005019117 date "2000-12-01" @default.
- W2005019117 modified "2023-10-11" @default.
- W2005019117 title "RIBEYE, a Component of Synaptic Ribbons" @default.
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- W2005019117 doi "https://doi.org/10.1016/s0896-6273(00)00159-8" @default.
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